ID   IMP4_RAT                Reviewed;         291 AA.
AC   Q5PQR5;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=U3 small nucleolar ribonucleoprotein protein IMP4;
DE            Short=U3 snoRNP protein IMP4;
GN   Name=Imp4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the 60-80S U3 small nucleolar ribonucleoprotein
CC       (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal
CC       RNA processing (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of a heterotrimeric complex containing IMP3, IMP4
CC       and MPHOSPH10. Interacts with MPHOSPH10 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
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DR   EMBL; BC087066; AAH87066.1; -; mRNA.
DR   RefSeq; NP_001009700.1; NM_001009700.1.
DR   AlphaFoldDB; Q5PQR5; -.
DR   SMR; Q5PQR5; -.
DR   STRING; 10116.ENSRNOP00000062237; -.
DR   iPTMnet; Q5PQR5; -.
DR   PhosphoSitePlus; Q5PQR5; -.
DR   PaxDb; Q5PQR5; -.
DR   Ensembl; ENSRNOT00000066913; ENSRNOP00000062237; ENSRNOG00000013285.
DR   GeneID; 316317; -.
DR   KEGG; rno:316317; -.
DR   UCSC; RGD:1308463; rat.
DR   CTD; 92856; -.
DR   RGD; 1308463; Imp4.
DR   eggNOG; KOG2781; Eukaryota.
DR   GeneTree; ENSGT00940000153231; -.
DR   HOGENOM; CLU_040063_2_0_1; -.
DR   InParanoid; Q5PQR5; -.
DR   OMA; IGTMSEQ; -.
DR   OrthoDB; 768872at2759; -.
DR   PhylomeDB; Q5PQR5; -.
DR   Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q5PQR5; -.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000013285; Expressed in heart and 20 other tissues.
DR   Genevisible; Q5PQR5; RN.
DR   GO; GO:0034457; C:Mpp10 complex; ISO:RGD.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0030684; C:preribosome; ISO:RGD.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0042134; F:rRNA primary transcript binding; IEA:InterPro.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   InterPro; IPR007109; Brix.
DR   InterPro; IPR044281; IMP4/RPF1.
DR   PANTHER; PTHR22734; PTHR22734; 1.
DR   Pfam; PF04427; Brix; 1.
DR   SMART; SM00879; Brix; 1.
DR   PROSITE; PS50833; BRIX; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..291
FT                   /note="U3 small nucleolar ribonucleoprotein protein IMP4"
FT                   /id="PRO_0000120239"
FT   DOMAIN          83..264
FT                   /note="Brix"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
SQ   SEQUENCE   291 AA;  33656 MW;  5AFF74AA16E0C7BC CRC64;
     MLRREARLRR EYLYRKAREE AQRSVQEKKE RVKRALEENQ LIPTELRREA LALQGSLEFD
     DAGGEGVTSH VDDEYRWAGV EDPKVMITTS RDPSSRLKMF AKELKLVFPG AQRMNRGRHE
     VGALVRACKA NGVTDLLVVH EHRGTPVGLI VSHLPFGPTA YFTLCNVVMR HDIPDLGTMS
     EAKPHLITHG FSSRLGKRVS DILRYLFPVP KDDSHRVITF ANQDDYISFR HHVYKKTDHR
     NVELTEVGPR FELKLYMIRL GTLEQEATAD VEWRWHPYTN TARKRVFLSA E