ID   IMP4_SCHPO              Reviewed;         289 AA.
AC   O13823;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 126.
DE   RecName: Full=U3 small nucleolar ribonucleoprotein protein imp4;
DE            Short=U3 snoRNP protein imp4;
GN   Name=imp4; ORFNames=SPAC19A8.07c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Component of the U3 small nucleolar ribonucleoprotein.
CC       Required for the early cleavages at sites A0, A1 and A2 during 18S
CC       ribosomal pre-RNA processing (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of a heterotrimeric complex containing imp3, imp4
CC       and mpp10. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
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DR   EMBL; CU329670; CAB11643.1; -; Genomic_DNA.
DR   PIR; T37954; T37954.
DR   RefSeq; NP_593785.1; NM_001019214.2.
DR   AlphaFoldDB; O13823; -.
DR   SMR; O13823; -.
DR   BioGRID; 278907; 4.
DR   IntAct; O13823; 1.
DR   STRING; 4896.SPAC19A8.07c.1; -.
DR   MaxQB; O13823; -.
DR   PaxDb; O13823; -.
DR   EnsemblFungi; SPAC19A8.07c.1; SPAC19A8.07c.1:pep; SPAC19A8.07c.
DR   GeneID; 2542446; -.
DR   KEGG; spo:SPAC19A8.07c; -.
DR   PomBase; SPAC19A8.07c; imp4.
DR   VEuPathDB; FungiDB:SPAC19A8.07c; -.
DR   eggNOG; KOG2781; Eukaryota.
DR   HOGENOM; CLU_040063_2_0_1; -.
DR   InParanoid; O13823; -.
DR   OMA; IGTMSEQ; -.
DR   PhylomeDB; O13823; -.
DR   Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:O13823; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0034457; C:Mpp10 complex; IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR   GO; GO:0042134; F:rRNA primary transcript binding; IEA:InterPro.
DR   GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; ISO:PomBase.
DR   InterPro; IPR007109; Brix.
DR   InterPro; IPR044281; IMP4/RPF1.
DR   PANTHER; PTHR22734; PTHR22734; 1.
DR   Pfam; PF04427; Brix; 1.
DR   SMART; SM00879; Brix; 1.
DR   PROSITE; PS50833; BRIX; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..289
FT                   /note="U3 small nucleolar ribonucleoprotein protein imp4"
FT                   /id="PRO_0000120243"
FT   DOMAIN          84..266
FT                   /note="Brix"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00034"
FT   REGION          42..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   289 AA;  33395 MW;  2B2F649485FAA0D3 CRC64;
     MLRRAVRERR QFIYKRNQEL QEAKLNEKRR ALRKALEGNK ELNKDLQEDS QLQKDYKYDE
     SRATQEETET NLDDEYHRLG EREPKVLVTT SREPSSRLAQ FAKEVRLLIP NSYRLNRGNI
     VVGSLVEAAR ANDITDIVIL HEHRGIPDGL VISHLPYGPT LSFSLHNVVL RHDIPNTGTM
     SEAYPHLIFE NLTSKLGKRV KTALSALFPP DPKDTTPRVV TFANTDDYIS FRHHIYAKTG
     PKQIILSEAG PRFEMKLFEI TLGTVDMVDA DVEWKLKPYQ RHKRDVLAE