APOC1_TUPGL
ID APOC1_TUPGL Reviewed; 88 AA.
AC Q9XSN5;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=Apolipoprotein C-I;
DE Short=Apo-CI;
DE Short=ApoC-I;
DE AltName: Full=Apolipoprotein C1;
DE Contains:
DE RecName: Full=Truncated apolipoprotein C-I;
DE Flags: Precursor;
GN Name=APOC1;
OS Tupaia glis (Common tree shrew) (Sorex glis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=9395;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RA Lu X.Y., Chen B.S., Wang K.Q., Zhao Y.L., Zhu D.M., Zen W.W., Xue H.;
RT "Cloning and sequencing of apolipoprotein CI cDNA of tree shrew.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibitor of lipoprotein binding to the low density
CC lipoprotein (LDL) receptor, LDL receptor-related protein, and very low
CC density lipoprotein (VLDL) receptor. Associates with high density
CC lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the
CC plasma and makes up about 10% of the protein of the VLDL and 2% of that
CC of HDL. Appears to interfere directly with fatty acid uptake and is
CC also the major plasma inhibitor of cholesteryl ester transfer protein
CC (CETP). Binds free fatty acids and reduces their intracellular
CC esterification. Modulates the interaction of APOE with beta-migrating
CC VLDL and inhibits binding of beta-VLDL to the LDL receptor-related
CC protein. {ECO:0000250|UniProtKB:P02654, ECO:0000250|UniProtKB:P33047}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02654}.
CC -!- SIMILARITY: Belongs to the apolipoprotein C1 family. {ECO:0000305}.
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DR EMBL; U86690; AAD32951.1; -; mRNA.
DR AlphaFoldDB; Q9XSN5; -.
DR SMR; Q9XSN5; -.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR Gene3D; 4.10.260.30; -; 1.
DR InterPro; IPR043081; ApoC-1_sf.
DR InterPro; IPR006781; ApoC-I.
DR PANTHER; PTHR16565; PTHR16565; 1.
DR Pfam; PF04691; ApoC-I; 1.
PE 3: Inferred from homology;
KW Lipid transport; Secreted; Signal; Transport; VLDL.
FT SIGNAL 1..26
FT /evidence="ECO:0000250"
FT CHAIN 27..88
FT /note="Apolipoprotein C-I"
FT /id="PRO_0000002019"
FT CHAIN 29..88
FT /note="Truncated apolipoprotein C-I"
FT /evidence="ECO:0000250|UniProtKB:P86336"
FT /id="PRO_0000391847"
SQ SEQUENCE 88 AA; 9804 MW; 37A946591EF1A4BF CRC64;
MRLLLSLPVL LVALSVVLER PAPAQAAPDF SSTLEGLPDK LKEFGNTLED KAKKAIERIK
QSDLPAKTRN WFTETFGKVR DTFKATFS