IMPA5_ARATH
ID IMPA5_ARATH Reviewed; 519 AA.
AC Q9FJ09;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Importin subunit alpha-5 {ECO:0000305};
DE Short=IMPa-5 {ECO:0000303|PubMed:18836040};
DE AltName: Full=Importin subunit alpha {ECO:0000255|PIRNR:PIRNR005673};
GN Name=IMPA5 {ECO:0000303|PubMed:18836040};
GN OrderedLocusNames=At5g49310 {ECO:0000312|Araport:AT5G49310};
GN ORFNames=K21P3.21 {ECO:0000312|EMBL:BAB10349.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10048488; DOI=10.1093/dnares/5.6.379;
RA Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence
RT features of the regions of 1,081,958 bp covered by seventeen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:379-391(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP GENE FAMILY.
RX PubMed=18836040; DOI=10.1105/tpc.108.060467;
RA Bhattacharjee S., Lee L.Y., Oltmanns H., Cao H., Gupta V., Cuperus J.,
RA Gelvin S.B.;
RT "IMPa-4, an Arabidopsis importin alpha isoform, is preferentially involved
RT in agrobacterium-mediated plant transformation.";
RL Plant Cell 20:2661-2680(2008).
CC -!- FUNCTION: Binds to conventional NLS motifs and mediates nuclear protein
CC import across the nuclear envelope. {ECO:0000250|UniProtKB:Q96321}.
CC -!- SUBUNIT: Forms a complex with importin subunit beta-1.
CC {ECO:0000250|UniProtKB:Q96321}.
CC -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000250|UniProtKB:Q96321}.
CC -!- SIMILARITY: Belongs to the importin alpha family. {ECO:0000305}.
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DR EMBL; AB016872; BAB10349.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95795.1; -; Genomic_DNA.
DR EMBL; DQ447054; ABE66233.1; -; mRNA.
DR RefSeq; NP_199742.1; NM_124308.2.
DR AlphaFoldDB; Q9FJ09; -.
DR SMR; Q9FJ09; -.
DR STRING; 3702.AT5G49310.1; -.
DR PaxDb; Q9FJ09; -.
DR PRIDE; Q9FJ09; -.
DR EnsemblPlants; AT5G49310.1; AT5G49310.1; AT5G49310.
DR GeneID; 834991; -.
DR Gramene; AT5G49310.1; AT5G49310.1; AT5G49310.
DR KEGG; ath:AT5G49310; -.
DR Araport; AT5G49310; -.
DR TAIR; locus:2155929; AT5G49310.
DR eggNOG; KOG0166; Eukaryota.
DR HOGENOM; CLU_018084_6_0_1; -.
DR InParanoid; Q9FJ09; -.
DR OrthoDB; 1111872at2759; -.
DR PhylomeDB; Q9FJ09; -.
DR PRO; PR:Q9FJ09; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FJ09; baseline and differential.
DR Genevisible; Q9FJ09; AT.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.20.5.690; -; 1.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR Pfam; PF00514; Arm; 7.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
DR PROSITE; PS51214; IBB; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Protein transport; Reference proteome; Repeat; Transport.
FT CHAIN 1..519
FT /note="Importin subunit alpha-5"
FT /id="PRO_0000431571"
FT DOMAIN 1..58
FT /note="IBB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00561"
FT REPEAT 103..143
FT /note="ARM 1"
FT /evidence="ECO:0000255"
FT REPEAT 146..185
FT /note="ARM 2"
FT /evidence="ECO:0000255"
FT REPEAT 188..228
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REPEAT 230..269
FT /note="ARM 4"
FT /evidence="ECO:0000255"
FT REPEAT 272..311
FT /note="ARM 5"
FT /evidence="ECO:0000255"
FT REPEAT 314..354
FT /note="ARM 6"
FT /evidence="ECO:0000255"
FT REPEAT 357..396
FT /note="ARM 7"
FT /evidence="ECO:0000255"
FT REPEAT 400..439
FT /note="ARM 8"
FT /evidence="ECO:0000255"
SQ SEQUENCE 519 AA; 58029 MW; AB618275078F8EB6 CRC64;
MSLRPSTKTE IRRIRYKVSV DAEEGRRRRE DFLVEIRKSK RNENLMKKRR VKVLPPDYKL
ISNDPFESLL EIANMITGVF SDDPSLQLEY TTRFRVVLSF DRSPPTDNVI KSGVVPRFVE
FLKKDDNPKL QFEAAWALTN IASGASEHTK VVIDHGVVPL FVQLLASPDD DVREQAIWGL
GNVAGDSIQC RDFVLNSGAF IPLLHQLNNH ATLSILRNAT WTLSNFFRGK PSPPFDLVKH
VLPVLKRLVY SDDEQVLIDA CWALSNLSDA SNENIQSVIE AGVVPRLVEL LQHASPVVLV
PALRCIGNIV SGNSQQTHCV INCGVLPVLA DLLTQNHMRG IRREACWTIS NITAGLEEQI
QSVIDANLIP SLVNLAQHAE FDIKKEAIWA ISNASVGGSP NQIKYLVEQN CIKALCDILV
CPDLRIILVS LGGLEMILIA GEVDKNLRDV NCYSQMIEDA EGLEKIENLQ HHGNNEIYEK
AVKILQTYGL VEEDGRLVEE EDEGGDGCSH PEFQFDFSR
