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IMPA6_ARATH
ID   IMPA6_ARATH             Reviewed;         538 AA.
AC   Q9FWY7;
DT   07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=Importin subunit alpha-6 {ECO:0000305};
DE            Short=IMPa-6 {ECO:0000303|PubMed:18836040};
GN   Name=IMPA6 {ECO:0000303|PubMed:18836040};
GN   OrderedLocusNames=At1g02690 {ECO:0000312|Araport:AT1G02690};
GN   ORFNames=T14P4.3 {ECO:0000312|EMBL:AAG10631.1};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   FUNCTION, AND GENE FAMILY.
RX   PubMed=18836040; DOI=10.1105/tpc.108.060467;
RA   Bhattacharjee S., Lee L.Y., Oltmanns H., Cao H., Gupta V., Cuperus J.,
RA   Gelvin S.B.;
RT   "IMPa-4, an Arabidopsis importin alpha isoform, is preferentially involved
RT   in agrobacterium-mediated plant transformation.";
RL   Plant Cell 20:2661-2680(2008).
CC   -!- FUNCTION: Binds to conventional NLS motifs and mediates nuclear protein
CC       import across the nuclear envelope (By similarity). Acts as cellular
CC       receptor for the nuclear import of the virD2 protein of Agrobacterium,
CC       but is not essential for Agrobacterium-mediated root transformation
CC       (PubMed:18836040). {ECO:0000250|UniProtKB:Q96321,
CC       ECO:0000269|PubMed:18836040}.
CC   -!- SUBUNIT: Forms a complex with importin subunit beta-1.
CC       {ECO:0000250|UniProtKB:Q96321}.
CC   -!- INTERACTION:
CC       Q9FWY7; O82132: DREB2A; NbExp=3; IntAct=EBI-4431755, EBI-1786840;
CC       Q9FWY7; Q39101: FER1; NbExp=3; IntAct=EBI-4431755, EBI-25513208;
CC       Q9FWY7; Q38830: IAA12; NbExp=3; IntAct=EBI-4431755, EBI-617608;
CC       Q9FWY7; P93830: IAA17; NbExp=3; IntAct=EBI-4431755, EBI-632243;
CC       Q9FWY7; O81313: IND; NbExp=3; IntAct=EBI-4431755, EBI-4446992;
CC   -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000250|UniProtKB:Q96321}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences. {ECO:0000305};
CC       Name=1;
CC         IsoId=Q9FWY7-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the importin alpha family. {ECO:0000305}.
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DR   EMBL; AC022521; AAG10631.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE27458.1; -; Genomic_DNA.
DR   EMBL; AY070068; AAL49825.1; -; mRNA.
DR   EMBL; AY096437; AAM20077.1; -; mRNA.
DR   PIR; A86157; A86157.
DR   RefSeq; NP_171769.1; NM_100149.4. [Q9FWY7-1]
DR   AlphaFoldDB; Q9FWY7; -.
DR   SMR; Q9FWY7; -.
DR   IntAct; Q9FWY7; 45.
DR   STRING; 3702.AT1G02690.2; -.
DR   PaxDb; Q9FWY7; -.
DR   PRIDE; Q9FWY7; -.
DR   ProteomicsDB; 248450; -. [Q9FWY7-1]
DR   EnsemblPlants; AT1G02690.1; AT1G02690.1; AT1G02690. [Q9FWY7-1]
DR   GeneID; 839517; -.
DR   Gramene; AT1G02690.1; AT1G02690.1; AT1G02690. [Q9FWY7-1]
DR   KEGG; ath:AT1G02690; -.
DR   Araport; AT1G02690; -.
DR   eggNOG; KOG0166; Eukaryota.
DR   HOGENOM; CLU_018084_5_0_1; -.
DR   PhylomeDB; Q9FWY7; -.
DR   PRO; PR:Q9FWY7; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9FWY7; baseline and differential.
DR   Genevisible; Q9FWY7; AT.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR   GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR   GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR   Gene3D; 1.20.5.690; -; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   InterPro; IPR036975; Importin-a_IBB_sf.
DR   InterPro; IPR024931; Importin_alpha.
DR   Pfam; PF00514; Arm; 8.
DR   Pfam; PF16186; Arm_3; 1.
DR   Pfam; PF01749; IBB; 1.
DR   PIRSF; PIRSF005673; Importin_alpha; 1.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 5.
DR   PROSITE; PS51214; IBB; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Nucleus; Protein transport; Reference proteome;
KW   Repeat; Transport.
FT   CHAIN           1..538
FT                   /note="Importin subunit alpha-6"
FT                   /id="PRO_0000431572"
FT   DOMAIN          1..58
FT                   /note="IBB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00561"
FT   REPEAT          109..149
FT                   /note="ARM 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          152..191
FT                   /note="ARM 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          194..234
FT                   /note="ARM 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          236..275
FT                   /note="ARM 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          278..317
FT                   /note="ARM 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          320..360
FT                   /note="ARM 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          363..402
FT                   /note="ARM 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          406..445
FT                   /note="ARM 8"
FT                   /evidence="ECO:0000255"
FT   REGION          1..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..50
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   538 AA;  59389 MW;  34ED12839C2EDF55 CRC64;
     MSYKPSAKTE VRRNRYKVSV DADEGRRRRE DNMVEIRKNK REENLQKKRR EGFNPSMASQ
     PGQDFSSSLP TETRLENIQQ MIAGVMSEDR DLQLEATASF RRLLSIERNP PINEVVQSGV
     VPHIVQFLSR DDFTQLQFEA AWALTNIASG TSENTRVIID SGAVPLFVKL LSSASEEVRE
     QAVWALGNVA GDSPKCRDHV LSCEAMMSLL AQFHEHSKLS MLRNATWTLS NFCRGKPQPA
     FEQTKAALPA LERLLHSTDE EVLTDASWAL SYLSDGTNEK IQTVIDAGVI PRLVQLLAHP
     SPSVLIPALR TIGNIVTGDD IQTQAVISSQ ALPGLLNLLK NTYKKSIKKE ACWTISNITA
     GNTSQIQEVF QAGIIRPLIN LLEIGEFEIK KEAVWAISNA TSGGNHDQIK FLVSQGCIRP
     LCDLLPCPDP RVVTVTLEGL ENILKVGEAE KNLGNTGNDN LYAQMIEDAD GLDKIENLQS
     HDNNEIYEKA VKILESYWAA DDEEEDIGGV DAPENVQSSG FQFGNQSGNA PTGGFNFG
 
 
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