IMPA7_ARATH
ID IMPA7_ARATH Reviewed; 528 AA.
AC Q9M9X7;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Importin subunit alpha-7 {ECO:0000305};
DE Short=IMPa-7 {ECO:0000303|PubMed:18836040};
GN Name=IMPA7 {ECO:0000303|PubMed:18836040};
GN OrderedLocusNames=At3g05720 {ECO:0000312|Araport:AT3G05720};
GN ORFNames=F18C1.1 {ECO:0000312|EMBL:AAF26125.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [4]
RP FUNCTION, AND GENE FAMILY.
RX PubMed=18836040; DOI=10.1105/tpc.108.060467;
RA Bhattacharjee S., Lee L.Y., Oltmanns H., Cao H., Gupta V., Cuperus J.,
RA Gelvin S.B.;
RT "IMPa-4, an Arabidopsis importin alpha isoform, is preferentially involved
RT in agrobacterium-mediated plant transformation.";
RL Plant Cell 20:2661-2680(2008).
CC -!- FUNCTION: Binds to conventional NLS motifs and mediates nuclear protein
CC import across the nuclear envelope (By similarity). Acts as cellular
CC receptor for the nuclear import of the virD2 protein of Agrobacterium,
CC but is not essential for Agrobacterium-mediated root transformation
CC (PubMed:18836040). {ECO:0000250|UniProtKB:Q96321,
CC ECO:0000269|PubMed:18836040}.
CC -!- SUBUNIT: Forms a complex with importin subunit beta-1.
CC {ECO:0000250|UniProtKB:Q96321}.
CC -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000250|UniProtKB:Q96321}.
CC -!- SIMILARITY: Belongs to the importin alpha family. {ECO:0000305}.
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DR EMBL; AC011620; AAF26125.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74284.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM65374.1; -; Genomic_DNA.
DR EMBL; DQ446636; ABE65918.1; -; mRNA.
DR RefSeq; NP_001319482.1; NM_001337604.1.
DR RefSeq; NP_187223.1; NM_111446.2.
DR AlphaFoldDB; Q9M9X7; -.
DR SMR; Q9M9X7; -.
DR STRING; 3702.AT3G05720.1; -.
DR iPTMnet; Q9M9X7; -.
DR PaxDb; Q9M9X7; -.
DR PRIDE; Q9M9X7; -.
DR ProteomicsDB; 248540; -.
DR EnsemblPlants; AT3G05720.1; AT3G05720.1; AT3G05720.
DR EnsemblPlants; AT3G05720.2; AT3G05720.2; AT3G05720.
DR GeneID; 819741; -.
DR Gramene; AT3G05720.1; AT3G05720.1; AT3G05720.
DR Gramene; AT3G05720.2; AT3G05720.2; AT3G05720.
DR KEGG; ath:AT3G05720; -.
DR Araport; AT3G05720; -.
DR TAIR; locus:2078122; AT3G05720.
DR eggNOG; KOG0166; Eukaryota.
DR HOGENOM; CLU_018084_6_0_1; -.
DR InParanoid; Q9M9X7; -.
DR OMA; VFDADIC; -.
DR OrthoDB; 1111872at2759; -.
DR PhylomeDB; Q9M9X7; -.
DR PRO; PR:Q9M9X7; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M9X7; baseline and differential.
DR Genevisible; Q9M9X7; AT.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.20.5.690; -; 1.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR Pfam; PF00514; Arm; 7.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 2.
DR PROSITE; PS51214; IBB; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Protein transport; Reference proteome; Repeat; Transport.
FT CHAIN 1..528
FT /note="Importin subunit alpha-7"
FT /id="PRO_0000431573"
FT DOMAIN 1..56
FT /note="IBB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00561"
FT REPEAT 93..133
FT /note="ARM 1"
FT /evidence="ECO:0000255"
FT REPEAT 136..175
FT /note="ARM 2"
FT /evidence="ECO:0000255"
FT REPEAT 178..218
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REPEAT 220..259
FT /note="ARM 4"
FT /evidence="ECO:0000255"
FT REPEAT 262..301
FT /note="ARM 5"
FT /evidence="ECO:0000255"
FT REPEAT 304..344
FT /note="ARM 6"
FT /evidence="ECO:0000255"
FT REPEAT 347..386
FT /note="ARM 7"
FT /evidence="ECO:0000255"
FT REPEAT 390..429
FT /note="ARM 8"
FT /evidence="ECO:0000255"
SQ SEQUENCE 528 AA; 58473 MW; DD542F7D1A6D31F8 CRC64;
MKGGETMSVR RSGYKAVVDG VGGRRRREDD MVEIRKAKRE ESLLKKRREA LPHSPSADSL
DQKLISCIWS DERDLLIEAT TQIRTLLCGE MFNVRVEEVI QAGLVPRFVE FLTWDDSPQL
QFEAAWALTN IASGTSENTE VVIDHGAVAI LVRLLNSPYD VVREQVVWAL GNISGDSPRC
RDIVLGHAAL PSLLLQLNHG AKLSMLVNAA WTLSNLCRGK PQPPFDQVSA ALPALAQLIR
LDDKELLAYT CWALVYLSDG SNEKIQAVIE ANVCARLIGL SIHRSPSVIT PALRTIGNIV
TGNDSQTQHI IDLQALPCLV NLLRGSYNKT IRKEACWTVS NITAGCQSQI QAVFDADICP
ALVNLLQNSE GDVKKEAAWA ICNAIAGGSY KQIMFLVKQE CIKPLCDLLT CSDTQLVMVC
LEALKKILKV GEVFSSRHAE GIYQCPQTNV NPHAQLIEEA EGLEKIEGLQ SHENNDIYET
AVKILETYWM EEEEEEDQEQ QDMIYFPVDN FANMPTSSGT LSEMHCGP
