IMPA9_ARATH
ID IMPA9_ARATH Reviewed; 519 AA.
AC F4KF65; Q9LYX8;
DT 07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Importin subunit alpha-9 {ECO:0000305};
DE Short=IMPa-9 {ECO:0000303|PubMed:18836040};
GN Name=IMPA9 {ECO:0000303|PubMed:18836040};
GN OrderedLocusNames=At5g03070 {ECO:0000312|Araport:AT5G03070};
GN ORFNames=F15A17.100 {ECO:0000312|EMBL:CAB86074.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, AND GENE FAMILY.
RX PubMed=18836040; DOI=10.1105/tpc.108.060467;
RA Bhattacharjee S., Lee L.Y., Oltmanns H., Cao H., Gupta V., Cuperus J.,
RA Gelvin S.B.;
RT "IMPa-4, an Arabidopsis importin alpha isoform, is preferentially involved
RT in agrobacterium-mediated plant transformation.";
RL Plant Cell 20:2661-2680(2008).
CC -!- FUNCTION: Binds to conventional NLS motifs and mediates nuclear protein
CC import across the nuclear envelope (By similarity). Acts as cellular
CC receptor for the nuclear import of the virD2 protein of Agrobacterium,
CC but is not essential for Agrobacterium-mediated root transformation
CC (PubMed:18836040). {ECO:0000250|UniProtKB:Q96321,
CC ECO:0000269|PubMed:18836040}.
CC -!- SUBUNIT: Forms a complex with importin subunit beta-1.
CC {ECO:0000250|UniProtKB:Q96321}.
CC -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000250|UniProtKB:Q96321}.
CC -!- SIMILARITY: Belongs to the importin alpha family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB86074.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL163002; CAB86074.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED90553.1; -; Genomic_DNA.
DR PIR; T48328; T48328.
DR RefSeq; NP_195927.2; NM_120385.4.
DR AlphaFoldDB; F4KF65; -.
DR SMR; F4KF65; -.
DR IntAct; F4KF65; 1.
DR STRING; 3702.AT5G03070.1; -.
DR PaxDb; F4KF65; -.
DR PRIDE; F4KF65; -.
DR ProteomicsDB; 247015; -.
DR EnsemblPlants; AT5G03070.1; AT5G03070.1; AT5G03070.
DR GeneID; 831675; -.
DR Gramene; AT5G03070.1; AT5G03070.1; AT5G03070.
DR KEGG; ath:AT5G03070; -.
DR Araport; AT5G03070; -.
DR TAIR; locus:2143423; AT5G03070.
DR eggNOG; KOG0166; Eukaryota.
DR HOGENOM; CLU_516194_0_0_1; -.
DR InParanoid; F4KF65; -.
DR OMA; QMRNMAN; -.
DR OrthoDB; 1401503at2759; -.
DR PRO; PR:F4KF65; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; F4KF65; baseline and differential.
DR Genevisible; F4KF65; AT.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR024931; Importin_alpha.
DR Pfam; PF00514; Arm; 2.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Nucleus; Protein transport; Reference proteome; Repeat; Transport.
FT CHAIN 1..519
FT /note="Importin subunit alpha-9"
FT /id="PRO_0000431575"
FT REPEAT 116..156
FT /note="ARM 1"
FT /evidence="ECO:0000255"
FT REPEAT 158..197
FT /note="ARM 2"
FT /evidence="ECO:0000255"
FT REPEAT 200..239
FT /note="ARM 3"
FT /evidence="ECO:0000255"
FT REPEAT 244..283
FT /note="ARM 4"
FT /evidence="ECO:0000255"
FT REPEAT 286..326
FT /note="ARM 5"
FT /evidence="ECO:0000255"
FT REPEAT 335..374
FT /note="ARM 6"
FT /evidence="ECO:0000255"
FT REPEAT 377..416
FT /note="ARM 7"
FT /evidence="ECO:0000255"
FT REPEAT 429..468
FT /note="ARM 8"
FT /evidence="ECO:0000255"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 56684 MW; 015E44E754AB3C19 CRC64;
MADDGSASNR RDPIKSSVGN VAGQRRRKQA VTVAKERREL LVRAKRLCRV GTNGDVEDAL
VENEMMVDEE QPILEAQASK SVEELKSAVQ YQGKGAMQKR VTALRELRRL LSKSEFPPVE
AALRAGAIPL LVQCLSFGSP DEQLLESAWC LTNIAAGKPE ETKALLPALP LLIAHLGEKS
SAPVAEQCAW AIGNVAGEGE DLRNVLLSQG ALPPLARMIF PDKGSTVRTA AWALSNLIKG
PESKAAAQLV KIDGILDAIL RHLKKTDEET ATEIAWIIVY LSALSDIATS MLLKGGILQL
LIDRLATSSS LQLLIPVLRS LGNFVAVDPK AVLTILIREQ NTEESIIGVL AKCLRSEHRV
LKKEAAWVLS NIAAGSIEHK RMIHSTEVMP LLLRILSTSP FDIRKEVAYV LGNLCVESAE
GDRKPRIIQE HLVSIVSGGC LRGFIELVRS PDIEAARLGL QFIELVLRGM PNGEGPKLVE
GEDGIDAMER FQFHENEELR VMANSLVDKY FGEDYGIDE
