ID   IMPO_ENCCU              Reviewed;         939 AA.
AC   Q8SR54;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Probable importin ECU10_0620;
DE   AltName: Full=Probable karyopherin ECU10_0620;
GN   OrderedLocusNames=ECU10_0620;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=16691553; DOI=10.1002/pmic.200500796;
RA   Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.;
RT   "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi
RT   (microsporidia): a reference map for proteins expressed in late sporogonial
RT   stages.";
RL   Proteomics 6:3625-3635(2006).
CC   -!- FUNCTION: Active in protein import into the nucleus. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in late sporogonial stages.
CC       {ECO:0000269|PubMed:16691553}.
CC   -!- SIMILARITY: Belongs to the importin beta family. {ECO:0000305}.
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DR   EMBL; AL590449; CAD25781.1; -; Genomic_DNA.
DR   RefSeq; NP_586177.1; NM_001042010.1.
DR   AlphaFoldDB; Q8SR54; -.
DR   SMR; Q8SR54; -.
DR   STRING; 284813.Q8SR54; -.
DR   GeneID; 859826; -.
DR   KEGG; ecu:ECU10_0620; -.
DR   VEuPathDB; MicrosporidiaDB:ECU10_0620; -.
DR   HOGENOM; CLU_013781_0_0_1; -.
DR   InParanoid; Q8SR54; -.
DR   OMA; TMTTMVM; -.
DR   OrthoDB; 159062at2759; -.
DR   Proteomes; UP000000819; Chromosome X.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..939
FT                   /note="Probable importin ECU10_0620"
FT                   /id="PRO_0000383141"
FT   DOMAIN          23..90
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
SQ   SEQUENCE   939 AA;  106952 MW;  374557B64290770C CRC64;
     MREETRQIFL QTIDSDAGKR SIAEAMLMDL EKQPGFVMSL PHTCMKDGDP IVKRVAAIYF
     KNAIIKQWRS NEYSEARKYL VENILDLFLY GDEVTRTAYN AILVNIFNNE KLSDLDGMFR
     KAAGFMRTSE ANHVLTALNM YERVFDAEKI KYNLEQVLGL MFDTAGKDIL EKVYGFLESG
     NYGMVKTGMI VLSKSYCYYS IPDFLSAIGT FSYVFNLSLR ILNLEGSNED LLESKKWAAY
     FMYKSCSKGI KKFYKKSELS EYITDMNRFQ MVYATFLKII QERSQQTIDI ELYAIDFFVL
     LTSDADFFRY MEPNLSYFIS GYILPLYSLS DSEEDDFEND PDKYLREKYN FFGNGLRSSL
     NTLFCEIISK VKQKEETFQG IISYLLSILG GSKETPSRDN IRAAYGSFFL LASIKSTLMK
     KARNVLEYIV ANHVIPALRG NSCILKSQAC YFLSTIEEDL PINGLALEAL DNTHKLMKSS
     HRALMVESTL AMSFFLFNEA SSEKFRQLIP ETVESILSLS NTYNLEPLTM LLDSIIGYYP
     EEISKYAPEL VGSISRITLS HLMNESDVGE DKQMVVSGFL RSIESLILSL DQRSLVLKYS
     YVNSYDVISF ILKEEKSDFY QEALDILNGY VYMIKEIEGS MWGLFQMVLN LPIDEITVYS
     TEVADLIDNF ITYGKTSVMD AGILGSICSV ISKLCLCNEE NFLDEDFIGG CRIIESIILN
     IGNELLSKDP SRLPLFISVA ISGEKMIDED GPAIVYALEL IMNCFILRPK ETIRILREQK
     YLQSFFEKLF SQKNKFKRVH DKKICMLFIG TICRLQDGAL PELDVHGLGE VLVATVTSLP
     EAIRLRNQMK DDEDAPPPLV NTEDDQCLDA SDISCTDILE EDIYFETELD KFEPFGYISS
     ILSSPASGTY AEKIISTMTD EQKDSLSTVL NGERIIQKI