ID   IMPX_YEAST              Reviewed;         346 AA.
AC   P32351; D6VVD3;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 2.
DT   03-AUG-2022, entry version 153.
DE   RecName: Full=Sugar utilization regulatory protein IMP2;
GN   Name=IMP2'; Synonyms=IMP2; OrderedLocusNames=YIL154C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-346.
RX   PubMed=1561839; DOI=10.1002/yea.320080203;
RA   Donnini C., Lodi T., Ferrero I., Puglisi P.P.;
RT   "IMP2, a nuclear gene controlling the mitochondrial dependence of
RT   galactose, maltose and raffinose utilization in Saccharomyces cerevisiae.";
RL   Yeast 8:83-93(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169870;
RA   Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA   Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA   Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA   Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA   Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL   Nature 387:84-87(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-24, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ADR376;
RX   PubMed=17330950; DOI=10.1021/pr060559j;
RA   Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,
RA   Elias J.E., Gygi S.P.;
RT   "Large-scale phosphorylation analysis of alpha-factor-arrested
RT   Saccharomyces cerevisiae.";
RL   J. Proteome Res. 6:1190-1197(2007).
CC   -!- FUNCTION: Controls the nucleo-mitochondrial dependence of galactose,
CC       maltose and raffinose utilization. Becomes essential in the absence of
CC       functioning mitochondria.
CC   -!- MISCELLANEOUS: Present with 5110 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; Z38059; CAA86124.1; -; Genomic_DNA.
DR   EMBL; X61928; CAA43930.1; -; Genomic_DNA.
DR   EMBL; BK006942; DAA08399.1; -; Genomic_DNA.
DR   PIR; S48380; S48380.
DR   RefSeq; NP_012112.3; NM_001179502.3.
DR   AlphaFoldDB; P32351; -.
DR   BioGRID; 34838; 187.
DR   DIP; DIP-5664N; -.
DR   IntAct; P32351; 6.
DR   MINT; P32351; -.
DR   STRING; 4932.YIL154C; -.
DR   iPTMnet; P32351; -.
DR   MaxQB; P32351; -.
DR   PaxDb; P32351; -.
DR   PRIDE; P32351; -.
DR   EnsemblFungi; YIL154C_mRNA; YIL154C; YIL154C.
DR   GeneID; 854652; -.
DR   KEGG; sce:YIL154C; -.
DR   SGD; S000001416; IMP2'.
DR   VEuPathDB; FungiDB:YIL154C; -.
DR   eggNOG; ENOG502QVSA; Eukaryota.
DR   HOGENOM; CLU_044106_0_0_1; -.
DR   OMA; QMFANVA; -.
DR   BioCyc; YEAST:G3O-31403-MON; -.
DR   PRO; PR:P32351; -.
DR   Proteomes; UP000002311; Chromosome IX.
DR   RNAct; P32351; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0003713; F:transcription coactivator activity; IDA:SGD.
DR   GO; GO:0000429; P:carbon catabolite regulation of transcription from RNA polymerase II promoter; IMP:SGD.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..346
FT                   /note="Sugar utilization regulatory protein IMP2"
FT                   /id="PRO_0000084187"
FT   REGION          1..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          91..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..132
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         24
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:17330950"
FT   CONFLICT        181
FT                   /note="D -> G (in Ref. 1; CAA43930)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        279
FT                   /note="D -> H (in Ref. 1; CAA43930)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        282
FT                   /note="D -> H (in Ref. 1; CAA43930)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   346 AA;  39071 MW;  5350D3B7E8DAE7D4 CRC64;
     MQKSILLTKP DGTQSNLHSI KTETPTTVEF DSEQMERGHR ERGRSKKKRG ERDSNVSSLS
     RSRSRASSRS RVREEEFLKW TVLRQDPSMR LRVVDVDSEE EGEGNDEDDD DGDGDDMDEE
     ESDEEQVSDI ENDLEIDEEF HYDLGMKVLP NFCTSINEVL DSSKPWIAKY EISIRGHENE
     DVSLEQLDGG YVRAMQLLTK GAGAEAGNQR SFILYTDLSS ESTYALTYLM GAAVNQGDTV
     YIVHWEPSKP TDDSQMFANV ARIRKHVMHL FDCVAGVLDD LDVVVLSLTH PYPKHLLNEM
     IHGLKPVALC CSLSVILSTL QNFVCSVPIL AVRKKLKRAK RKGISE