ID   IMP_CNIQU               Reviewed;          25 AA.
AC   C0HLQ3;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   07-OCT-2020, sequence version 1.
DT   25-MAY-2022, entry version 4.
DE   RecName: Full=Insulin mimetic protein {ECO:0000303|PubMed:32413470};
DE            Short=Cq-IMP {ECO:0000303|PubMed:32413470};
DE   Flags: Fragment;
OS   Cnidoscolus quercifolius.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae;
OC   Cnidoscolus.
OX   NCBI_TaxID=2358373 {ECO:0000303|PubMed:32413470};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, TISSUE SPECIFICITY, GLYCOSYLATION, AND MASS SPECTROMETRY.
RC   TISSUE=Seed {ECO:0000303|PubMed:32413470};
RX   PubMed=32413470; DOI=10.1016/j.ijbiomac.2020.05.033;
RA   Moura L.F.W.G., da Silva Costa H.P., da Silva Neto J.X., Dias L.P.,
RA   Magalhaes F.E.A., van Tilburg M.F., Florean E.O.P.T., de Oliveira J.T.A.,
RA   Oliveira Bezerra de Sousa D., Guedes M.I.F.;
RT   "Orally hypoglycemic activity of an insulin mimetic glycoprotein isolated
RT   from Cnidoscolus quercifolius Pohl. (Euphorbiaceae) seeds, Cq-IMP.";
RL   Int. J. Biol. Macromol. 159:886-895(2020).
CC   -!- TISSUE SPECIFICITY: Expressed in seed. {ECO:0000269|PubMed:32413470}.
CC   -!- PTM: Glycosylated. {ECO:0000269|PubMed:32413470}.
CC   -!- MASS SPECTROMETRY: Mass=11188; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:32413470};
CC   -!- MISCELLANEOUS: Exhibits hypoglycemic activity in RIN-5F cells (in
CC       vitro) and in diabetic mice (in vivo). No hemagglutinating activity on
CC       rabbit erythrocytes and does not increase IgG and IgE immunoglobulins
CC       in rabbit plasma. {ECO:0000269|PubMed:32413470}.
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DR   AlphaFoldDB; C0HLQ3; -.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein.
FT   CHAIN           1..>25
FT                   /note="Insulin mimetic protein"
FT                   /id="PRO_0000450850"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         25
FT                   /evidence="ECO:0000303|PubMed:32413470"
SQ   SEQUENCE   25 AA;  3094 MW;  FD57793043FA1C72 CRC64;
     TKDPELKQCK KQQKKQQQYD DDDKK