APOC2_BOVIN
ID APOC2_BOVIN Reviewed; 101 AA.
AC P19034; A6H771; Q71VH7;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Apolipoprotein C-II;
DE Short=Apo-CII;
DE Short=ApoC-II;
DE AltName: Full=Apolipoprotein C2;
DE Contains:
DE RecName: Full=Proapolipoprotein C-II;
DE Short=ProapoC-II;
DE Flags: Precursor;
GN Name=APOC2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PROTEIN SEQUENCE OF 23-101, PROTEOLYTIC PROCESSING, AND FUNCTION.
RX PubMed=2209608; DOI=10.1111/j.1432-1033.1990.tb19255.x;
RA Bengtsson-Olivecrona G., Sletten K.;
RT "Primary structure of the bovine analogues to human apolipoproteins CII and
RT CIII. Studies on isoforms and evidence for proteolytic processing.";
RL Eur. J. Biochem. 192:515-521(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 65-83.
RX PubMed=10675035; DOI=10.1016/s0378-1119(99)00492-8;
RA Brzozowska A., Sundvold H., Lien S., Rogne S.;
RT "Evolutionary conservation of the apolipoprotein E-C1-C2 gene cluster on
RT bovine chromosome 18q24.";
RL Gene 241:241-245(2000).
CC -!- FUNCTION: Component of chylomicrons, very low-density lipoproteins
CC (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins
CC (HDL) in plasma. Plays an important role in lipoprotein metabolism as
CC an activator of lipoprotein lipase. Both proapolipoprotein C-II and
CC apolipoprotein C-II can activate lipoprotein lipase.
CC {ECO:0000269|PubMed:2209608}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02655}.
CC -!- PTM: Proapolipoprotein C-II is synthesized as a sialic acid containing
CC glycoprotein which is subsequently desialylated prior to its
CC proteolytic processing. {ECO:0000250|UniProtKB:P02655}.
CC -!- PTM: Proapolipoprotein C-II undergoes proteolytic cleavage of its N-
CC terminal hexapeptide to generate apolipoprotein C-II. In bovine,
CC proapolipoprotein C-II was found to be the minor form whereas
CC apolipoprotein C-II was found to be the major form in plasma.
CC {ECO:0000269|PubMed:2209608}.
CC -!- SIMILARITY: Belongs to the apolipoprotein C2 family. {ECO:0000305}.
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DR EMBL; BC146135; AAI46136.1; -; mRNA.
DR EMBL; AF007114; AAB63893.1; -; Genomic_DNA.
DR PIR; S13187; S13187.
DR RefSeq; NP_001095850.1; NM_001102380.2.
DR RefSeq; XP_015313666.1; XM_015458180.1.
DR AlphaFoldDB; P19034; -.
DR SMR; P19034; -.
DR STRING; 9913.ENSBTAP00000027393; -.
DR PaxDb; P19034; -.
DR PRIDE; P19034; -.
DR Ensembl; ENSBTAT00000027393; ENSBTAP00000027393; ENSBTAG00000020558.
DR GeneID; 618039; -.
DR KEGG; bta:618039; -.
DR CTD; 344; -.
DR VEuPathDB; HostDB:ENSBTAG00000020558; -.
DR VGNC; VGNC:52176; APOC2.
DR eggNOG; ENOG502SEJB; Eukaryota.
DR GeneTree; ENSGT00390000007913; -.
DR HOGENOM; CLU_180154_0_0_1; -.
DR InParanoid; P19034; -.
DR OMA; EVQGAHL; -.
DR OrthoDB; 1548460at2759; -.
DR TreeFam; TF338218; -.
DR Proteomes; UP000009136; Chromosome 18.
DR Bgee; ENSBTAG00000020558; Expressed in liver and 45 other tissues.
DR ExpressionAtlas; P19034; baseline and differential.
DR GO; GO:0042627; C:chylomicron; IBA:GO_Central.
DR GO; GO:0034363; C:intermediate-density lipoprotein particle; IBA:GO_Central.
DR GO; GO:0034362; C:low-density lipoprotein particle; IBA:GO_Central.
DR GO; GO:0034366; C:spherical high-density lipoprotein particle; IBA:GO_Central.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; IBA:GO_Central.
DR GO; GO:0008289; F:lipid binding; IBA:GO_Central.
DR GO; GO:0060230; F:lipoprotein lipase activator activity; IBA:GO_Central.
DR GO; GO:0016004; F:phospholipase activator activity; IBA:GO_Central.
DR GO; GO:0043274; F:phospholipase binding; IBA:GO_Central.
DR GO; GO:0034382; P:chylomicron remnant clearance; IBA:GO_Central.
DR GO; GO:0034384; P:high-density lipoprotein particle clearance; IBA:GO_Central.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IBA:GO_Central.
DR GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; NAS:BHF-UCL.
DR GO; GO:0051006; P:positive regulation of lipoprotein lipase activity; IBA:GO_Central.
DR GO; GO:0010518; P:positive regulation of phospholipase activity; IBA:GO_Central.
DR GO; GO:0060697; P:positive regulation of phospholipid catabolic process; IBA:GO_Central.
DR GO; GO:0010898; P:positive regulation of triglyceride catabolic process; NAS:BHF-UCL.
DR Gene3D; 1.10.1440.10; -; 1.
DR InterPro; IPR008019; Apo-CII.
DR InterPro; IPR023121; ApoC-II_dom_sf.
DR PANTHER; PTHR16566; PTHR16566; 1.
DR Pfam; PF05355; Apo-CII; 1.
PE 1: Evidence at protein level;
KW Chylomicron; Direct protein sequencing; Glycoprotein; HDL; LDL;
KW Lipid degradation; Lipid metabolism; Lipid transport; Reference proteome;
KW Secreted; Sialic acid; Signal; Transport; VLDL.
FT SIGNAL 1..22
FT /evidence="ECO:0000269|PubMed:2209608"
FT CHAIN 23..101
FT /note="Proapolipoprotein C-II"
FT /evidence="ECO:0000269|PubMed:2209608"
FT /id="PRO_0000002020"
FT CHAIN 29..101
FT /note="Apolipoprotein C-II"
FT /id="PRO_0000002021"
FT REGION 66..74
FT /note="Lipid binding"
FT /evidence="ECO:0000250|UniProtKB:P02655"
FT REGION 78..101
FT /note="Lipoprotein lipase cofactor"
FT /evidence="ECO:0000250|UniProtKB:P02655"
SQ SEQUENCE 101 AA; 11061 MW; 39CDE51823345F98 CRC64;
MGTRYFLVGF LILLVLGFEV QGAHVPQQDE ASSPALLTQV QESLLGYWDT AKAAAQKLYK
KTYLPAVDEK IRDIYSKSTA AVTTYAGIIT DQVFSVLSGK D
