ID   IMQD_ASPFN              Reviewed;         406 AA.
AC   B8NI21;
DT   20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Peptide transporter imqD {ECO:0000303|PubMed:29182847};
DE   AltName: Full=Imizoquin biosynthesis cluster protein D {ECO:0000303|PubMed:29182847};
GN   Name=imqD {ECO:0000303|PubMed:29182847}; ORFNames=AFLA_064260;
OS   Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS   / JCM 12722 / SRRC 167).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=332952;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC
RC   167;
RX   PubMed=25883274; DOI=10.1128/genomea.00168-15;
RA   Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA   Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT   "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT   aflatoxin contamination of food and feed.";
RL   Genome Announc. 3:E0016815-E0016815(2015).
RN   [2]
RP   INDUCTION, AND FUNCTION.
RX   PubMed=29182847; DOI=10.1021/acschembio.7b00731;
RA   Khalid S., Baccile J.A., Spraker J.E., Tannous J., Imran M.,
RA   Schroeder F.C., Keller N.P.;
RT   "NRPS-derived isoquinolines and lipopetides mediate antagonism between
RT   plant pathogenic fungi and bacteria.";
RL   ACS Chem. Biol. 13:171-179(2018).
CC   -!- FUNCTION: Peptide transporter; part of the gene cluster that mediates
CC       the biosynthesis of imizoquins A to D, tripeptide-derived alkaloids
CC       that serve a protective role against oxidative stress that are
CC       essential for normal germination (PubMed:29182847).
CC       {ECO:0000269|PubMed:29182847}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Expression is down-regulated by ralstonins, lipopeptides
CC       produced by the plant pathogenic bacteria Ralstonia solanacearum
CC       (PubMed:29182847). Expression is positively regulated by the imizoquins
CC       cluster-specific transcription regulator imqK (PubMed:29182847).
CC       {ECO:0000269|PubMed:29182847}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Proton-
CC       dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.
CC       {ECO:0000305}.
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DR   EMBL; EQ963479; EED49605.1; -; Genomic_DNA.
DR   RefSeq; XP_002379986.1; XM_002379945.1.
DR   AlphaFoldDB; B8NI21; -.
DR   SMR; B8NI21; -.
DR   EnsemblFungi; EED49605; EED49605; AFLA_064260.
DR   VEuPathDB; FungiDB:AFLA_064260; -.
DR   eggNOG; KOG1237; Eukaryota.
DR   HOGENOM; CLU_004790_4_2_1; -.
DR   OMA; ITRMATG; -.
DR   Proteomes; UP000001875; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR000109; POT_fam.
DR   PANTHER; PTHR11654; PTHR11654; 1.
DR   Pfam; PF00854; PTR2; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..406
FT                   /note="Peptide transporter imqD"
FT                   /id="PRO_0000444548"
FT   TRANSMEM        184..204
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   406 AA;  44932 MW;  8ABC9392148EBDEF CRC64;
     MTAPADSTEK SETSETTTLQ TTEVSTVDVD PDLPRVLAKV PGTVWVVAFI AAAERFTYWG
     ITTPWQLHAK PPQASEFARC IRPRRSESIH DIQCLHVFLL FNTNSFRDNL GRLSRSLSDI
     APEFDKRFRK LPPTGNILPK AGSVLSCAIR GRFQLDAAMP SYQREHFAKE VSWDETFVNE
     IRRGLVACRV ILGFILFFTC LSQASNNLIS QAGQMKTYGI PNDTITAMNP IFCVIMGPVI
     QKGLYPLLNK NNVKFQSITR MATGFIMMSA SMAFAAGVQK IIYDTGPCYD RPLTCPGAEN
     GRIPNQVNVF LQTPTYIILA VAEIFSFVTL SEYTYTKAPT DMKAVVQALG QLGAAAGSAI
     GIAITPLAHD PSLIWMYTGL AVAMFLVAVV FWILFKKYNA IDREDK