ID   IMSP6_RUDPH             Reviewed;         183 AA.
AC   P86987;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Insoluble matrix shell protein 6 {ECO:0000303|PubMed:21221694};
DE            Short=IMSP6 {ECO:0000303|PubMed:21221694};
DE   Flags: Precursor;
OS   Ruditapes philippinarum (Japanese littleneck clam) (Venerupis
OS   philippinarum).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Heteroconchia; Euheterodonta; Imparidentia; Neoheterodontei;
OC   Venerida; Veneroidea; Veneridae; Ruditapes.
OX   NCBI_TaxID=129788;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Beck A.;
RL   Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 72-79.
RC   TISSUE=Shell {ECO:0000269|PubMed:21221694};
RX   PubMed=21221694; DOI=10.1007/s10126-010-9357-0;
RA   Marie B., Trinkler N., Zanella-Cleon I., Guichard N., Becchi M.,
RA   Paillard C., Marin F.;
RT   "Proteomic identification of novel proteins from the calcifying shell
RT   matrix of the manila clam Venerupis Philippinarum.";
RL   Mar. Biotechnol. 13:955-962(2011).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21221694}.
CC   -!- TISSUE SPECIFICITY: Component of the acid-insoluble organic matrix of
CC       the calcified shell. {ECO:0000269|PubMed:21221694}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM876820; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P86987; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   SMART; SM00280; KAZAL; 2.
DR   SUPFAM; SSF100895; SSF100895; 2.
DR   PROSITE; PS00282; KAZAL_1; 2.
DR   PROSITE; PS51465; KAZAL_2; 2.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Repeat; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..183
FT                   /note="Insoluble matrix shell protein 6"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000413030"
FT   DOMAIN          23..69
FT                   /note="Kazal-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
FT   DOMAIN          137..181
FT                   /note="Kazal-like 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00798"
SQ   SEQUENCE   183 AA;  20553 MW;  DE6BA5DA5610C683 CRC64;
     MKLEIALLLL AVTVCVKGGF LQGRSGYDCR RRCGYDRRYV CSTDGTTYDN ECMMKCNWAY
     KSCDGRCPCY RSPAPVVYRP KPAVVYKPRP VVNYEPASVN YEPASVNYEP AAVDYPSVPD
     YEPIPVYNEP APVYYDVPVQ SDCVCSKDKD YVCTYDGETY DNECEANCDG KAKMCDGQCP
     CSK