APOC2_CANLF
ID APOC2_CANLF Reviewed; 101 AA.
AC P12278;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1989, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Apolipoprotein C-II;
DE Short=Apo-CII;
DE Short=ApoC-II;
DE AltName: Full=Apolipoprotein C2;
DE Contains:
DE RecName: Full=Proapolipoprotein C-II;
DE Short=ProapoC-II;
DE Flags: Precursor;
GN Name=APOC2;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=2956259; DOI=10.1016/s0021-9258(18)61003-8;
RA Datta S., Li W.-H., Ghosh I., Luo C.-C., Chan L.;
RT "Structure and expression of dog apolipoprotein C-II and C-III mRNAs.
RT Implications for the evolution and functional constraints of apolipoprotein
RT structure.";
RL J. Biol. Chem. 262:10588-10593(1987).
RN [2]
RP PROTEIN SEQUENCE OF 78-98, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Plasma;
RX PubMed=20483223; DOI=10.1016/j.cbd.2008.08.002;
RA Puppione D.L., Bassilian S., Souda P., MacDonald M.H., Halgand F.,
RA Hagland F., Whitelegge J.P.;
RT "Mass spectral analysis of the apolipoproteins on dog (Canis lupus
RT familiaris) high density lipoproteins. Detection of apolipoprotein A-II.";
RL Comp. Biochem. Physiol. 3:290-296(2008).
CC -!- FUNCTION: Component of chylomicrons, very low-density lipoproteins
CC (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins
CC (HDL) in plasma. Plays an important role in lipoprotein metabolism as
CC an activator of lipoprotein lipase. Both proapolipoprotein C-II and
CC apolipoprotein C-II can activate lipoprotein lipase.
CC {ECO:0000250|UniProtKB:P02655}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02655}.
CC -!- TISSUE SPECIFICITY: Highly expressed in the liver. Moderately expressed
CC in the ileum, jejunum and ovary. {ECO:0000269|PubMed:2956259}.
CC -!- PTM: Proapolipoprotein C-II is synthesized as a sialic acid containing
CC glycoprotein which is subsequently desialylated prior to its
CC proteolytic processing. {ECO:0000250|UniProtKB:P02655}.
CC -!- PTM: Proapolipoprotein C-II, the major form found in plasma undergoes
CC proteolytic cleavage of its N-terminal hexapeptide to generate
CC apolipoprotein C-II, which occurs as the minor form in plasma.
CC {ECO:0000250|UniProtKB:P02655}.
CC -!- SIMILARITY: Belongs to the apolipoprotein C2 family. {ECO:0000305}.
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DR EMBL; M17177; AAA30829.1; -; mRNA.
DR PIR; A28487; A28487.
DR RefSeq; NP_001003368.1; NM_001003368.1.
DR AlphaFoldDB; P12278; -.
DR SMR; P12278; -.
DR STRING; 9615.ENSCAFP00000006882; -.
DR PaxDb; P12278; -.
DR Ensembl; ENSCAFT00030003915; ENSCAFP00030003475; ENSCAFG00030002139.
DR Ensembl; ENSCAFT00040021204; ENSCAFP00040018404; ENSCAFG00040011476.
DR Ensembl; ENSCAFT00845011687; ENSCAFP00845009125; ENSCAFG00845006579.
DR GeneID; 442969; -.
DR KEGG; cfa:442969; -.
DR CTD; 344; -.
DR VEuPathDB; HostDB:ENSCAFG00845006579; -.
DR eggNOG; ENOG502SEJB; Eukaryota.
DR GeneTree; ENSGT00390000007913; -.
DR HOGENOM; CLU_180154_0_0_1; -.
DR InParanoid; P12278; -.
DR OrthoDB; 1548460at2759; -.
DR Proteomes; UP000002254; Chromosome 1.
DR Bgee; ENSCAFG00000004610; Expressed in liver and 47 other tissues.
DR GO; GO:0042627; C:chylomicron; IBA:GO_Central.
DR GO; GO:0034363; C:intermediate-density lipoprotein particle; IBA:GO_Central.
DR GO; GO:0034362; C:low-density lipoprotein particle; IBA:GO_Central.
DR GO; GO:0034366; C:spherical high-density lipoprotein particle; IBA:GO_Central.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; IBA:GO_Central.
DR GO; GO:0055102; F:lipase inhibitor activity; IEA:Ensembl.
DR GO; GO:0008289; F:lipid binding; IBA:GO_Central.
DR GO; GO:0060230; F:lipoprotein lipase activator activity; IBA:GO_Central.
DR GO; GO:0016004; F:phospholipase activator activity; IBA:GO_Central.
DR GO; GO:0043274; F:phospholipase binding; IBA:GO_Central.
DR GO; GO:0033344; P:cholesterol efflux; IEA:Ensembl.
DR GO; GO:0034382; P:chylomicron remnant clearance; IBA:GO_Central.
DR GO; GO:0034384; P:high-density lipoprotein particle clearance; IBA:GO_Central.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0032375; P:negative regulation of cholesterol transport; IEA:Ensembl.
DR GO; GO:0045833; P:negative regulation of lipid metabolic process; IEA:Ensembl.
DR GO; GO:0048261; P:negative regulation of receptor-mediated endocytosis; IEA:Ensembl.
DR GO; GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; IBA:GO_Central.
DR GO; GO:0033700; P:phospholipid efflux; IEA:Ensembl.
DR GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; IEA:Ensembl.
DR GO; GO:0051006; P:positive regulation of lipoprotein lipase activity; IBA:GO_Central.
DR GO; GO:0010518; P:positive regulation of phospholipase activity; IBA:GO_Central.
DR GO; GO:0060697; P:positive regulation of phospholipid catabolic process; IBA:GO_Central.
DR GO; GO:0010898; P:positive regulation of triglyceride catabolic process; IEA:Ensembl.
DR GO; GO:0070328; P:triglyceride homeostasis; IEA:Ensembl.
DR Gene3D; 1.10.1440.10; -; 1.
DR InterPro; IPR008019; Apo-CII.
DR InterPro; IPR023121; ApoC-II_dom_sf.
DR PANTHER; PTHR16566; PTHR16566; 1.
DR Pfam; PF05355; Apo-CII; 1.
PE 1: Evidence at protein level;
KW Chylomicron; Direct protein sequencing; Glycoprotein; HDL; LDL;
KW Lipid degradation; Lipid metabolism; Lipid transport; Reference proteome;
KW Secreted; Sialic acid; Signal; Transport; VLDL.
FT SIGNAL 1..22
FT CHAIN 23..101
FT /note="Proapolipoprotein C-II"
FT /id="PRO_0000002022"
FT CHAIN 29..101
FT /note="Apolipoprotein C-II"
FT /evidence="ECO:0000250|UniProtKB:P02655"
FT /id="PRO_0000430836"
FT REGION 66..74
FT /note="Lipid binding"
FT /evidence="ECO:0000250|UniProtKB:P02655"
FT REGION 78..101
FT /note="Lipoprotein lipase cofactor"
FT /evidence="ECO:0000250|UniProtKB:P02655"
SQ SEQUENCE 101 AA; 11227 MW; 2FFC5C0B9AA447FC CRC64;
MGTRYLLVLL LVLLVLGFEV QGAHESQQDE TTSSALLTQM QESLYSYWGT ARSAAEDLYK
KAYPTTMDEK IRDIYSKSTA AVSTYAGIFT DQLLSMLKGD S
