IMUP_HUMAN
ID IMUP_HUMAN Reviewed; 106 AA.
AC Q9GZP8; Q0P6G2; Q96H58; Q9HCR4;
DT 04-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Immortalization up-regulated protein;
DE AltName: Full=Hepatocyte growth factor activator inhibitor type 2-related small protein;
DE Short=H2RSP;
DE Short=HAI-2-related small protein;
GN Name=IMUP; Synonyms=C19orf33;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND SUBCELLULAR LOCATION.
RC TISSUE=Lung;
RX PubMed=11080599; DOI=10.1016/s0378-1119(00)00414-5;
RA Kim J.K., Ryll R., Ishizuka Y., Kato S.;
RT "Identification of cDNAs encoding two novel nuclear proteins, IMUP-1 and
RT IMUP-2, upregulated in SV40-immortalized human fibroblasts.";
RL Gene 257:327-334(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
RX PubMed=11606055; DOI=10.1006/bbrc.2001.5767;
RA Itoh H.K., Kataoka H., Yamauchi M., Naganuma S., Akiyama Y., Nuki Y.,
RA Shimomura T., Miyazawa K., Kitamura N., Koono M.R.;
RT "Identification of hepatocyte growth factor activator inhibitor type 2
RT (HAI-2)-related small peptide (H2RSP): its nuclear localization and
RT generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes.";
RL Biochem. Biophys. Res. Commun. 288:390-399(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Lung, Pancreas, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11080599}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=IMUP-1;
CC IsoId=Q9GZP8-1; Sequence=Displayed;
CC Name=2; Synonyms=IMUP-2;
CC IsoId=Q9GZP8-2; Sequence=VSP_007919;
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DR EMBL; AB038317; BAB18465.1; -; mRNA.
DR EMBL; AB038318; BAB18466.1; -; mRNA.
DR EMBL; AF213678; AAG43574.1; -; mRNA.
DR EMBL; AF325216; AAK01421.1; -; Genomic_DNA.
DR EMBL; BC008888; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; CH471126; EAW56770.1; -; Genomic_DNA.
DR EMBL; BC014264; AAH14264.1; -; mRNA.
DR EMBL; BC060319; AAH60319.1; -; mRNA.
DR CCDS; CCDS12511.1; -. [Q9GZP8-1]
DR CCDS; CCDS82344.1; -. [Q9GZP8-2]
DR PIR; JC7778; JC7778.
DR RefSeq; NP_001304730.1; NM_001317801.1. [Q9GZP8-2]
DR RefSeq; NP_277055.1; NM_033520.2. [Q9GZP8-1]
DR AlphaFoldDB; Q9GZP8; -.
DR BioGRID; 122043; 4.
DR IntAct; Q9GZP8; 1.
DR STRING; 9606.ENSP00000301246; -.
DR iPTMnet; Q9GZP8; -.
DR PhosphoSitePlus; Q9GZP8; -.
DR BioMuta; C19orf33; -.
DR DMDM; 33516918; -.
DR EPD; Q9GZP8; -.
DR jPOST; Q9GZP8; -.
DR MassIVE; Q9GZP8; -.
DR MaxQB; Q9GZP8; -.
DR PaxDb; Q9GZP8; -.
DR PeptideAtlas; Q9GZP8; -.
DR PRIDE; Q9GZP8; -.
DR ProteomicsDB; 80108; -. [Q9GZP8-1]
DR ProteomicsDB; 80109; -. [Q9GZP8-2]
DR TopDownProteomics; Q9GZP8-1; -. [Q9GZP8-1]
DR Antibodypedia; 54571; 49 antibodies from 10 providers.
DR DNASU; 64073; -.
DR Ensembl; ENST00000301246.10; ENSP00000301246.4; ENSG00000167644.12. [Q9GZP8-1]
DR Ensembl; ENST00000588605.5; ENSP00000464940.1; ENSG00000167644.12. [Q9GZP8-2]
DR GeneID; 64073; -.
DR KEGG; hsa:64073; -.
DR MANE-Select; ENST00000301246.10; ENSP00000301246.4; NM_033520.3; NP_277055.1.
DR UCSC; uc002ohu.2; human. [Q9GZP8-1]
DR CTD; 64073; -.
DR DisGeNET; 64073; -.
DR GeneCards; C19orf33; -.
DR HGNC; HGNC:16668; C19orf33.
DR HPA; ENSG00000167644; Tissue enhanced (esophagus, skin).
DR MIM; 619711; gene.
DR neXtProt; NX_Q9GZP8; -.
DR OpenTargets; ENSG00000167644; -.
DR PharmGKB; PA134924870; -.
DR VEuPathDB; HostDB:ENSG00000167644; -.
DR eggNOG; ENOG502TD4H; Eukaryota.
DR GeneTree; ENSGT00940000163639; -.
DR HOGENOM; CLU_177127_0_0_1; -.
DR InParanoid; Q9GZP8; -.
DR OMA; DTDVKPH; -.
DR PhylomeDB; Q9GZP8; -.
DR PathwayCommons; Q9GZP8; -.
DR SignaLink; Q9GZP8; -.
DR BioGRID-ORCS; 64073; 8 hits in 1041 CRISPR screens.
DR ChiTaRS; C19orf33; human.
DR GenomeRNAi; 64073; -.
DR Pharos; Q9GZP8; Tbio.
DR PRO; PR:Q9GZP8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9GZP8; protein.
DR Bgee; ENSG00000167644; Expressed in lower esophagus mucosa and 93 other tissues.
DR Genevisible; Q9GZP8; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:HGNC-UCL.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR InterPro; IPR026621; IMUP.
DR Pfam; PF15761; IMUP; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..106
FT /note="Immortalization up-regulated protein"
FT /id="PRO_0000084191"
FT REGION 1..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..97
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 29
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 47..106
FT /note="QGHHSSSDSSSSSSDSDTDVKSHAAGSKQHESIPGKAKKPKVKKKEKGKKEK
FT GKKKEAPH -> ASNFRGLGKGRRLTAAPPSSKDTTALPTPAAAPAIRTRM (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:11080599,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_007919"
SQ SEQUENCE 106 AA; 10897 MW; CB0D3F56E1870DAE CRC64;
MEFDLGAALE PTSQKPGVGA GHGGDPKLSP HKVQGRSEAG AGPGPKQGHH SSSDSSSSSS
DSDTDVKSHA AGSKQHESIP GKAKKPKVKK KEKGKKEKGK KKEAPH
