ID   IN80C_RAT               Reviewed;         191 AA.
AC   Q5BJY3;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=INO80 complex subunit C;
GN   Name=Ino80c;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Proposed core component of the chromatin remodeling INO80
CC       complex which is involved in transcriptional regulation, DNA
CC       replication and probably DNA repair.
CC   -!- SUBUNIT: Component of the chromatin remodeling INO80 complex;
CC       specifically part of a complex module associated with the helicase ATP-
CC       binding and the helicase C-terminal domain of INO80. Component of some
CC       MLL1/MLL complex, at least composed of the core components KMT2A/MLL1,
CC       ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative
CC       components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1,
CC       MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B,
CC       SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC091281; AAH91281.1; -; mRNA.
DR   RefSeq; NP_001017446.1; NM_001017446.1.
DR   AlphaFoldDB; Q5BJY3; -.
DR   SMR; Q5BJY3; -.
DR   STRING; 10116.ENSRNOP00000022169; -.
DR   PhosphoSitePlus; Q5BJY3; -.
DR   PaxDb; Q5BJY3; -.
DR   Ensembl; ENSRNOT00000022169; ENSRNOP00000022169; ENSRNOG00000016532.
DR   GeneID; 291737; -.
DR   KEGG; rno:291737; -.
DR   UCSC; RGD:1310199; rat.
DR   CTD; 125476; -.
DR   RGD; 1310199; Ino80c.
DR   eggNOG; KOG4137; Eukaryota.
DR   GeneTree; ENSGT00390000014303; -.
DR   HOGENOM; CLU_071116_0_0_1; -.
DR   InParanoid; Q5BJY3; -.
DR   OMA; ATTQAQM; -.
DR   OrthoDB; 1560268at2759; -.
DR   PhylomeDB; Q5BJY3; -.
DR   TreeFam; TF323529; -.
DR   Reactome; R-RNO-5689603; UCH proteinases.
DR   Reactome; R-RNO-5696394; DNA Damage Recognition in GG-NER.
DR   ChiTaRS; Ino80c; rat.
DR   PRO; PR:Q5BJY3; -.
DR   Proteomes; UP000002494; Chromosome 18.
DR   Bgee; ENSRNOG00000016532; Expressed in quadriceps femoris and 20 other tissues.
DR   Genevisible; Q5BJY3; RN.
DR   GO; GO:0031011; C:Ino80 complex; ISO:RGD.
DR   GO; GO:0071339; C:MLL1 complex; ISS:UniProtKB.
DR   GO; GO:0006338; P:chromatin remodeling; ISO:RGD.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0045739; P:positive regulation of DNA repair; ISO:RGD.
DR   GO; GO:1904507; P:positive regulation of telomere maintenance in response to DNA damage; ISO:RGD.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
DR   GO; GO:0051726; P:regulation of cell cycle; ISO:RGD.
DR   GO; GO:0033044; P:regulation of chromosome organization; ISO:RGD.
DR   GO; GO:0006282; P:regulation of DNA repair; ISO:RGD.
DR   GO; GO:0006275; P:regulation of DNA replication; ISO:RGD.
DR   GO; GO:0060382; P:regulation of DNA strand elongation; ISO:RGD.
DR   GO; GO:0045995; P:regulation of embryonic development; ISO:RGD.
DR   GO; GO:0000723; P:telomere maintenance; ISO:RGD.
DR   InterPro; IPR029525; INO80C/Ies6.
DR   InterPro; IPR013272; Vps72/YL1_C.
DR   PANTHER; PTHR31200; PTHR31200; 1.
DR   Pfam; PF08265; YL1_C; 1.
DR   SMART; SM00993; YL1_C; 1.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA recombination; DNA repair; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..191
FT                   /note="INO80 complex subunit C"
FT                   /id="PRO_0000079319"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..35
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   191 AA;  20424 MW;  09AD29E0A914A73B CRC64;
     MAAQIPIVAA TSTPTVARNS KKRPASPSHN SSGGGYGASK KKKLSASGFA QGVSIEAMSE
     SKMASSELSS GPVEKAAKPL PFKDPNFVHS GHGGAVAGKK NRTWKNLKQI LAAERALPWQ
     LNDPNYFSID APPSFKPAKK YSDVSGLLAN YTDPQSKLRF STVEEFSYIR RLPSDVVTGY
     LTLRKATSIV P