IN80D_MOUSE
ID IN80D_MOUSE Reviewed; 1021 AA.
AC Q66JY2; E9Q9Q0; E9QLE8; Q8BQK5;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 31-JUL-2019, sequence version 4.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=INO80 complex subunit D {ECO:0000305};
GN Name=Ino80d {ECO:0000312|MGI:MGI:3027003};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-539 (ISOFORM 4).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 99-717 (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative regulatory component of the chromatin remodeling
CC INO80 complex which is involved in transcriptional regulation, DNA
CC replication and probably DNA repair. {ECO:0000250}.
CC -!- SUBUNIT: Component of the chromatin remodeling INO80 complex;
CC specifically part of a complex module associated with the N-terminus of
CC INO80. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=3;
CC IsoId=Q66JY2-3; Sequence=Displayed;
CC Name=4;
CC IsoId=Q66JY2-4; Sequence=VSP_060240;
CC -!- SIMILARITY: Belongs to the INO80D family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH80705.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH80705.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AL645950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL645685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK049468; BAC33763.1; -; mRNA.
DR EMBL; BC080705; AAH80705.1; ALT_SEQ; mRNA.
DR CCDS; CCDS35594.1; -. [Q66JY2-4]
DR CCDS; CCDS48277.1; -. [Q66JY2-3]
DR RefSeq; NP_001074905.1; NM_001081436.2. [Q66JY2-4]
DR RefSeq; NP_001108081.1; NM_001114609.1. [Q66JY2-3]
DR RefSeq; XP_006496009.1; XM_006495946.2. [Q66JY2-3]
DR RefSeq; XP_006496010.1; XM_006495947.2. [Q66JY2-3]
DR RefSeq; XP_006496011.1; XM_006495948.2. [Q66JY2-3]
DR AlphaFoldDB; Q66JY2; -.
DR SMR; Q66JY2; -.
DR BioGRID; 230598; 2.
DR ComplexPortal; CPX-878; INO80 chromatin remodeling complex.
DR STRING; 10090.ENSMUSP00000130864; -.
DR iPTMnet; Q66JY2; -.
DR PhosphoSitePlus; Q66JY2; -.
DR EPD; Q66JY2; -.
DR MaxQB; Q66JY2; -.
DR PaxDb; Q66JY2; -.
DR PeptideAtlas; Q66JY2; -.
DR PRIDE; Q66JY2; -.
DR ProteomicsDB; 269313; -. [Q66JY2-3]
DR ProteomicsDB; 320923; -.
DR Antibodypedia; 51926; 55 antibodies from 14 providers.
DR Ensembl; ENSMUST00000097718; ENSMUSP00000095325; ENSMUSG00000040865. [Q66JY2-3]
DR Ensembl; ENSMUST00000133236; ENSMUSP00000123430; ENSMUSG00000040865. [Q66JY2-4]
DR Ensembl; ENSMUST00000137511; ENSMUSP00000119118; ENSMUSG00000040865. [Q66JY2-3]
DR Ensembl; ENSMUST00000153992; ENSMUSP00000115332; ENSMUSG00000040865. [Q66JY2-4]
DR GeneID; 227195; -.
DR KEGG; mmu:227195; -.
DR CTD; 54891; -.
DR MGI; MGI:3027003; Ino80d.
DR VEuPathDB; HostDB:ENSMUSG00000040865; -.
DR eggNOG; ENOG502QQC5; Eukaryota.
DR GeneTree; ENSGT00940000157974; -.
DR HOGENOM; CLU_329723_0_0_1; -.
DR InParanoid; Q66JY2; -.
DR OMA; VKARHQM; -.
DR OrthoDB; 172254at2759; -.
DR TreeFam; TF324169; -.
DR Reactome; R-MMU-5689603; UCH proteinases.
DR Reactome; R-MMU-5696394; DNA Damage Recognition in GG-NER.
DR BioGRID-ORCS; 227195; 3 hits in 111 CRISPR screens.
DR ChiTaRS; Ino80d; mouse.
DR PRO; PR:Q66JY2; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q66JY2; protein.
DR Bgee; ENSMUSG00000040865; Expressed in animal zygote and 216 other tissues.
DR ExpressionAtlas; Q66JY2; baseline and differential.
DR GO; GO:0031011; C:Ino80 complex; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; ISO:MGI.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0045739; P:positive regulation of DNA repair; IDA:ComplexPortal.
DR GO; GO:1904507; P:positive regulation of telomere maintenance in response to DNA damage; IMP:ComplexPortal.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0051726; P:regulation of cell cycle; ISO:MGI.
DR GO; GO:0033044; P:regulation of chromosome organization; ISO:MGI.
DR GO; GO:0006282; P:regulation of DNA repair; IDA:ComplexPortal.
DR GO; GO:0006275; P:regulation of DNA replication; ISO:MGI.
DR GO; GO:0060382; P:regulation of DNA strand elongation; ISO:MGI.
DR GO; GO:0045995; P:regulation of embryonic development; IMP:ComplexPortal.
DR GO; GO:0000723; P:telomere maintenance; IMP:ComplexPortal.
DR InterPro; IPR025927; Potential_DNA-bd.
DR Pfam; PF13891; zf-C3Hc3H; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA damage; DNA recombination; DNA repair;
KW Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Ubl conjugation.
FT CHAIN 1..1021
FT /note="INO80 complex subunit D"
FT /id="PRO_0000319586"
FT REGION 194..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..1021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..212
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..553
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..1014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 132
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q53TQ3"
FT CROSSLNK 87
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q53TQ3"
FT VAR_SEQ 1..105
FT /note="Missing (in isoform 4)"
FT /id="VSP_060240"
SQ SEQUENCE 1021 AA; 112362 MW; CD85869DE1DCB876 CRC64;
MYEGKHIHFS EVDNKPLCSY SPKLCKQRRL NGYAFCIRHV LEDKTAPFKQ CEYVAKYNSQ
RCTNPIPKSE DRRYCNSHLQ VLGFIPKKER KKKTDPVDEV KARHQMDAMA FSLTVPTLAL
KMPNGLDSMS LSPPGARVPL HYLDTELEDP FAFNEEDDDL KKGVTVRKKL QSKLAQNRQR
QRETEILKVR QEHFSTPPTP PQQHTHLSPL STSLKPPAPP QGSVCKSPQP QNTSLPMQGV
APTTHSIAQI RQASHKRPLP LLPSSRAPIS DAPRTDRILM KAAAFSPHLS CISRLQRLVK
LCTQKRQLDA DLFPHLGLDW SEESGEELED ADQASPYQVA WSIRETLRHE RHTSDDDDME
SRSSRVTQLC TYFQQKYKHL CRLERAESRQ KKCRHTFRKA LLQAASKEPE CTGQLIQELR
RAACSRASLR QTKLKEVEPA ACSGTVKGEQ CTKQALPFTR HCFQHILLNR SQQLFSSCTA
KFADGQQCSV PVFDITHQTP LCEEHAKKMD NFLRGDNSRK VQHQQQRKPR KKTKPPALTK
KHKKKRRRGP RRPQKPIPPA VPQGNLSMPT SVSLPVEASQ MRSPSTPELS ADELPDDIAN
EITDIPHDLE LNQEDFADVL PRLPDDLQDF DFFEGKNGDL LPTTEEAEEL ERALQAVTSL
ECLSTIGVLS QSDGVPVQGL SDRGMGVFST GTDASGIQSL SREVNTDLGE LLNGRIVHDS
FSSLELDENL LHSAPLSSPP TALAGQIQGQ FSAPASAGLT SATLLSQSAL GERAFPGQFH
GLHDGSHASQ RPHPAQLLSK ADDLITSRQQ YSSDHSHSSP HGSHYDSEHV PSPYSDHITS
PHTSYSGDNM AATFSAEMPI MAQHLLPTQL EVPLGGVVNP RTHWGNLPVN LGDPSAFSNL
LGADGHLLST SLSTPPTTSN SETTQPAFAT VTPSSSSVLP GLPQTSFSGM GPSAELMAST
SPKQQLPQFS AAFGHQLSSH SGIPKDLQPS HSSIAPPTGF TATGATATST NNASPPFPSP
N
