ID   IN80E_RAT               Reviewed;         244 AA.
AC   Q6AYH2;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=INO80 complex subunit E;
DE   AltName: Full=Coiled-coil domain-containing protein 95;
GN   Name=Ino80e; Synonyms=Ccdc95;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Putative regulatory component of the chromatin remodeling
CC       INO80 complex which is involved in transcriptional regulation, DNA
CC       replication and probably DNA repair. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the chromatin remodeling INO80 complex;
CC       specifically part of a complex module associated with the N-terminus of
CC       INO80. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR   EMBL; BC079045; AAH79045.1; -; mRNA.
DR   RefSeq; NP_001013922.1; NM_001013900.1.
DR   AlphaFoldDB; Q6AYH2; -.
DR   STRING; 10116.ENSRNOP00000027034; -.
DR   jPOST; Q6AYH2; -.
DR   PaxDb; Q6AYH2; -.
DR   Ensembl; ENSRNOT00000104647; ENSRNOP00000088985; ENSRNOG00000019960.
DR   GeneID; 293494; -.
DR   KEGG; rno:293494; -.
DR   UCSC; RGD:1359572; rat.
DR   CTD; 283899; -.
DR   RGD; 1359572; Ino80e.
DR   eggNOG; ENOG502RZ5F; Eukaryota.
DR   GeneTree; ENSGT00390000011918; -.
DR   HOGENOM; CLU_099081_0_0_1; -.
DR   InParanoid; Q6AYH2; -.
DR   OMA; EMNGQTD; -.
DR   OrthoDB; 1299948at2759; -.
DR   PhylomeDB; Q6AYH2; -.
DR   TreeFam; TF326931; -.
DR   Reactome; R-RNO-5689603; UCH proteinases.
DR   Reactome; R-RNO-5696394; DNA Damage Recognition in GG-NER.
DR   PRO; PR:Q6AYH2; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000019960; Expressed in frontal cortex and 20 other tissues.
DR   Genevisible; Q6AYH2; RN.
DR   GO; GO:0031011; C:Ino80 complex; ISO:RGD.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0006338; P:chromatin remodeling; ISO:RGD.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0045739; P:positive regulation of DNA repair; ISO:RGD.
DR   GO; GO:1904507; P:positive regulation of telomere maintenance in response to DNA damage; ISO:RGD.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
DR   GO; GO:0051726; P:regulation of cell cycle; ISO:RGD.
DR   GO; GO:0033044; P:regulation of chromosome organization; ISO:RGD.
DR   GO; GO:0006282; P:regulation of DNA repair; ISO:RGD.
DR   GO; GO:0006275; P:regulation of DNA replication; ISO:RGD.
DR   GO; GO:0060382; P:regulation of DNA strand elongation; ISO:RGD.
DR   GO; GO:0045995; P:regulation of embryonic development; ISO:RGD.
DR   GO; GO:0000723; P:telomere maintenance; ISO:RGD.
DR   InterPro; IPR026678; INO80E.
DR   PANTHER; PTHR21812; PTHR21812; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; DNA damage; DNA recombination; DNA repair; Isopeptide bond;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation;
KW   Ubl conjugation.
FT   CHAIN           1..244
FT                   /note="INO80 complex subunit E"
FT                   /id="PRO_0000234293"
FT   REGION          59..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          10..54
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        72..86
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        104..130
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..146
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        159
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NBZ0"
FT   CROSSLNK        171
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NBZ0"
SQ   SEQUENCE   244 AA;  26358 MW;  A28776CEC894E0F7 CRC64;
     MNGPADGEVD YKKKYRNLKR KLKFLIYEHE CFQEELRKAQ RKLLKVSRDK SFLLDRLLQY
     ENVDEDSSDS DATASSDNSE TEGTPKLSDT PAPKRKRSPP MGGAPSPSSL SLPPSSGFPL
     QTSGAPSPYL SSLASPPYPP FPSDYLALQL PEPSPLRPKL EKRPRLPRKL KMAVGPPDCP
     VGGPLAFPAR GSGASVGAAL TPLPPPKMPP HTILSTVPQQ MFSDAGSGDD ALDGDDDLVI
     DIPE