ID   INAA_ECOLI              Reviewed;         216 AA.
AC   P27294; P77545;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 3.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Protein InaA;
GN   Name=inaA; Synonyms=yfaG; OrderedLocusNames=b2237, JW2231;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6087316; DOI=10.1073/pnas.81.14.4294;
RA   Carlson J., Fuchs J.A., Messing J.;
RT   "Primary structure of the Escherichia coli ribonucleoside diphosphate
RT   reductase operon.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:4294-4297(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA   Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA   Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA   Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA   Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA   Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT   "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT   genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT   its sequence features.";
RL   DNA Res. 4:91-113(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [5]
RP   CHARACTERIZATION.
RX   PubMed=1537798; DOI=10.1128/jb.174.5.1537-1543.1992;
RA   White S., Tuttle F.E., Blankenhorn D., Dosch D.C., Slonczewski J.L.;
RT   "pH dependence and gene structure of inaA in Escherichia coli.";
RL   J. Bacteriol. 174:1537-1543(1992).
CC   -!- FUNCTION: May be an environmental sensor responsive to several stimuli,
CC       including internal pH, proton motive force, temperature, and possibly
CC       other unknown factors.
CC   -!- INDUCTION: By several factors in addition of internal pH.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. KdkA/RfaP
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=K02672; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; K02672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; U00096; AAC75297.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA16056.1; -; Genomic_DNA.
DR   PIR; C64994; C64994.
DR   RefSeq; NP_416740.1; NC_000913.3.
DR   RefSeq; WP_000301050.1; NZ_LN832404.1.
DR   AlphaFoldDB; P27294; -.
DR   SMR; P27294; -.
DR   BioGRID; 4260494; 15.
DR   IntAct; P27294; 13.
DR   STRING; 511145.b2237; -.
DR   PaxDb; P27294; -.
DR   PRIDE; P27294; -.
DR   EnsemblBacteria; AAC75297; AAC75297; b2237.
DR   EnsemblBacteria; BAA16056; BAA16056; BAA16056.
DR   GeneID; 66673874; -.
DR   GeneID; 946731; -.
DR   KEGG; ecj:JW2231; -.
DR   KEGG; eco:b2237; -.
DR   PATRIC; fig|511145.12.peg.2326; -.
DR   EchoBASE; EB1392; -.
DR   eggNOG; COG3642; Bacteria.
DR   HOGENOM; CLU_094468_0_0_6; -.
DR   InParanoid; P27294; -.
DR   OMA; WVEEPNQ; -.
DR   PhylomeDB; P27294; -.
DR   BioCyc; EcoCyc:EG11422-MON; -.
DR   PRO; PR:P27294; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR027023; Put_LipoPS_kinase_InaA.
DR   PIRSF; PIRSF026326; InaA; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..216
FT                   /note="Protein InaA"
FT                   /id="PRO_0000084193"
SQ   SEQUENCE   216 AA;  25296 MW;  49B8E72F553113FD CRC64;
     MAVSAKYDEF NHWWATEGDW VEEPNYRRNG MSGVQCVERN GKKLYVKRMT HHLFHSVRYP
     FGRPTIVREV AVIKELERAG VIVPKIVFGE AVKIEGEWRA LLVTEDMAGF ISIADWYAQH
     AVSPYSDEVR QAMLKAVALA FKKMHSINRQ HGCCYVRHIY VKTEGNAEAG FLDLEKSRRR
     LRRDKAINHD FRQLEKYLEP IPKADWEQVK AYYYAM