INAM1_HUMAN
ID INAM1_HUMAN Reviewed; 142 AA.
AC C9JVW0;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Putative transmembrane protein INAFM1 {ECO:0000305};
DE AltName: Full=InaF-motif-containing protein 1 {ECO:0000312|HGNC:HGNC:27406};
DE AltName: Full=Proline-rich protein 24 {ECO:0000312|HGNC:HGNC:27406};
GN Name=INAFM1 {ECO:0000312|HGNC:HGNC:27406};
GN Synonyms=PRR24 {ECO:0000312|HGNC:HGNC:27406};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AC008532; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46131.1; -.
DR RefSeq; NP_848606.3; NM_178511.5.
DR AlphaFoldDB; C9JVW0; -.
DR SMR; C9JVW0; -.
DR STRING; 9606.ENSP00000447679; -.
DR TCDB; 8.A.135.2.1; the trp cation channel auxiliary subunit, inaf (inaf) family.
DR BioMuta; INAFM1; -.
DR jPOST; C9JVW0; -.
DR MassIVE; C9JVW0; -.
DR PaxDb; C9JVW0; -.
DR PeptideAtlas; C9JVW0; -.
DR PRIDE; C9JVW0; -.
DR ProteomicsDB; 11908; -.
DR Antibodypedia; 67949; 59 antibodies from 12 providers.
DR Ensembl; ENST00000552360.4; ENSP00000447679.1; ENSG00000257704.4.
DR GeneID; 255783; -.
DR KEGG; hsa:255783; -.
DR MANE-Select; ENST00000552360.4; ENSP00000447679.1; NM_178511.6; NP_848606.3.
DR UCSC; uc002pgi.4; human.
DR CTD; 255783; -.
DR DisGeNET; 255783; -.
DR GeneCards; INAFM1; -.
DR HGNC; HGNC:27406; INAFM1.
DR HPA; ENSG00000257704; Low tissue specificity.
DR neXtProt; NX_C9JVW0; -.
DR OpenTargets; ENSG00000257704; -.
DR VEuPathDB; HostDB:ENSG00000257704; -.
DR eggNOG; ENOG502SYRX; Eukaryota.
DR GeneTree; ENSGT00550000076229; -.
DR HOGENOM; CLU_1805556_0_0_1; -.
DR InParanoid; C9JVW0; -.
DR OMA; RRYSNPG; -.
DR PhylomeDB; C9JVW0; -.
DR PathwayCommons; C9JVW0; -.
DR BioGRID-ORCS; 255783; 25 hits in 1063 CRISPR screens.
DR ChiTaRS; INAFM1; human.
DR GenomeRNAi; 255783; -.
DR Pharos; C9JVW0; Tbio.
DR PRO; PR:C9JVW0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; C9JVW0; protein.
DR Bgee; ENSG00000257704; Expressed in decidua and 174 other tissues.
DR Genevisible; C9JVW0; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR029162; InaF-motif.
DR Pfam; PF15018; InaF-motif; 1.
PE 4: Predicted;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..142
FT /note="Putative transmembrane protein INAFM1"
FT /id="PRO_0000394048"
FT TRANSMEM 36..56
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..83
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 142 AA; 14668 MW; 9F25234D6106E829 CRC64;
MRGTSCVGGG AESPGGAGLS EGPRGRWLRL APVCAYFLCV SLAAVLLAVY YGLIWVPTRS
PAAPAGPQPS APSPPCAARP GVPPVPAPAA ASLSCLLGVP GGPRPQLQLP LSRRRRYSDP
DRRPSRQTPR ETPEAAEGRR PG
