ID   INAM2_HUMAN             Reviewed;         153 AA.
AC   P0DMQ5;
DT   26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT   26-NOV-2014, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Putative transmembrane protein INAFM2 {ECO:0000305};
DE   AltName: Full=InaF-motif-containing protein 2 {ECO:0000312|HGNC:HGNC:35165};
DE   AltName: Full=Osteogenesis up-regulated transcript 1 {ECO:0000303|PubMed:19531736};
GN   Name=INAFM2 {ECO:0000312|HGNC:HGNC:35165};
GN   Synonyms=LINC00984 {ECO:0000312|HGNC:HGNC:35165},
GN   OGU1 {ECO:0000303|PubMed:19531736};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
RN   [2]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=19531736; DOI=10.1093/nar/gkp426;
RA   Kikuchi K., Fukuda M., Ito T., Inoue M., Yokoi T., Chiku S., Mitsuyama T.,
RA   Asai K., Hirose T., Aizawa Y.;
RT   "Transcripts of unknown function in multiple-signaling pathways involved in
RT   human stem cell differentiation.";
RL   Nucleic Acids Res. 37:4987-5000(2009).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- DEVELOPMENTAL STAGE: Up-regulated during osteogenesis.
CC       {ECO:0000269|PubMed:19531736}.
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DR   EMBL; AC013356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS86448.1; -.
DR   RefSeq; NP_001288197.1; NM_001301268.1.
DR   RefSeq; XP_011519451.1; XM_011521149.2.
DR   AlphaFoldDB; P0DMQ5; -.
DR   TCDB; 8.A.135.2.2; the trp cation channel auxiliary subunit, inaf (inaf) family.
DR   BioMuta; INAFM2; -.
DR   EPD; P0DMQ5; -.
DR   jPOST; P0DMQ5; -.
DR   MassIVE; P0DMQ5; -.
DR   PeptideAtlas; P0DMQ5; -.
DR   PRIDE; P0DMQ5; -.
DR   DNASU; 100505573; -.
DR   Ensembl; ENST00000638170.2; ENSP00000492634.1; ENSG00000259330.3.
DR   GeneID; 100505573; -.
DR   KEGG; hsa:100505573; -.
DR   MANE-Select; ENST00000638170.2; ENSP00000492634.1; NM_001301268.2; NP_001288197.1.
DR   CTD; 100505573; -.
DR   DisGeNET; 100505573; -.
DR   GeneCards; INAFM2; -.
DR   HGNC; HGNC:35165; INAFM2.
DR   HPA; ENSG00000259330; Low tissue specificity.
DR   neXtProt; NX_P0DMQ5; -.
DR   OpenTargets; ENSG00000259330; -.
DR   VEuPathDB; HostDB:ENSG00000259330; -.
DR   GeneTree; ENSGT00390000005766; -.
DR   OrthoDB; 1623788at2759; -.
DR   PathwayCommons; P0DMQ5; -.
DR   BioGRID-ORCS; 100505573; 3 hits in 88 CRISPR screens.
DR   ChiTaRS; INAFM2; human.
DR   Pharos; P0DMQ5; Tdark.
DR   PRO; PR:P0DMQ5; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; P0DMQ5; protein.
DR   Bgee; ENSG00000259330; Expressed in right coronary artery and 164 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR029162; InaF-motif.
DR   Pfam; PF15018; InaF-motif; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..153
FT                   /note="Putative transmembrane protein INAFM2"
FT                   /id="PRO_0000430932"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          66..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..134
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..153
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   153 AA;  15439 MW;  0AE157A698C9FD7B CRC64;
     MKERDAAPAE RGKPATYTGD KKAKMAAKTN KKWVRLATVF AYVLSVSLAA IVLAVYYSLI
     WQPVGAGTSG GAAGPPPGGS NATGPSGTSG AAAAGPNTTG SSRREAPRDV PPLQAARPAP
     PEPPADSPPA GPLERPRGPD EDEEETAAAP GSR