ID   INCA_CHLT9              Reviewed;         273 AA.
AC   D6YXE8; O84121; Q99Q56; Q9AM94; Q9AMA7; Q9AMA8; Q9AMA9; Q9AMB0; Q9AMB1;
AC   Q9F7K9; Q9RFX7;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   10-AUG-2010, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Inclusion membrane protein A;
GN   Name=incA; OrderedLocusNames=CTG9301_00615;
OS   Chlamydia trachomatis serovar G (strain G/9301).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=718219;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12177343; DOI=10.1099/00221287-148-8-2497;
RA   Rockey D.D., Viratyosin W., Bannantine J.P., Suchland R.J., Stamm W.E.;
RT   "Diversity within inc genes of clinical Chlamydia trachomatis variant
RT   isolates that occupy non-fusogenic inclusions.";
RL   Microbiology 148:2497-2505(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G/9301;
RX   PubMed=20308297; DOI=10.1128/iai.01324-09;
RA   Jeffrey B.M., Suchland R.J., Quinn K.L., Davidson J.R., Stamm W.E.,
RA   Rockey D.D.;
RT   "Genome sequencing of recent clinical Chlamydia trachomatis strains
RT   identifies loci associated with tissue tropism and regions of apparent
RT   recombination.";
RL   Infect. Immun. 78:2544-2553(2010).
CC   -!- FUNCTION: Chlamydia replicate within an intracellular vacuole, termed
CC       an inclusion. IncA is probably involved in the homotypic fusion of
CC       inclusions. {ECO:0000250|UniProtKB:A0A0H3MD02}.
CC   -!- SUBUNIT: Forms homooligomers. {ECO:0000250|UniProtKB:A0A0H3MD02}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:A0A0H3MD02}. Host
CC       vacuole, host pathogen-containing vacuole, host pathogen-containing
CC       vacuole membrane {ECO:0000305}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:A0A0H3MD02}. Note=Secreted, probably by a type
CC       III secretion system (By similarity). Localized in inclusion membrane
CC       (By similarity). In the inclusion, the C-terminus faces the host
CC       cytosol (By similarity). {ECO:0000250,
CC       ECO:0000250|UniProtKB:A0A0H3MD02}.
CC   -!- DOMAIN: IncA proteins share the same general organization: a short N-
CC       terminal domain, a large bilobed hydrophobic domain, and a C-terminal
CC       cytoplasmic domain. {ECO:0000250|UniProtKB:A0A0H3MD02}.
CC   -!- SIMILARITY: Belongs to the IncA family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF327329; AAK11233.1; -; Genomic_DNA.
DR   EMBL; CP001930; ADH96752.1; -; Genomic_DNA.
DR   RefSeq; WP_009871466.1; NC_017432.1.
DR   AlphaFoldDB; D6YXE8; -.
DR   SMR; D6YXE8; -.
DR   KEGG; ctv:CTG9301_00615; -.
DR   PATRIC; fig|718219.3.peg.134; -.
DR   HOGENOM; CLU_067042_0_0_0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0140221; C:pathogen-containing vacuole membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Coiled coil; Host membrane; Membrane; Secreted; Transmembrane;
KW   Transmembrane helix; Virulence.
FT   CHAIN           1..273
FT                   /note="Inclusion membrane protein A"
FT                   /id="PRO_0000400079"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        64..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          254..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          172..233
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   273 AA;  30327 MW;  6945AE7E8B8BEBF3 CRC64;
     MTTPTLIVTP PSPPAPSYSA NRVPQPSLMD KIKKIAAIAS LILIGTIGFL ALLGHLVGFL
     IAPQITIVLL ALFIISLAGN ALYLQKTANL HLYQDLQREV GSLKEINFML SVLQKEFLHL
     SKEFATTSKD LSAVSQDFYS CLQGFRDNYK GFESLLDEYK NSTEEMRKLF SQEIIADLKG
     SVASLREEIR FLTPLAEEVR RLAHNQQSLT VVIEELKTIR DSLRDEIGQL SQLSKTLTSQ
     IALQRKESSD LCSQIRETLS SPRKSASPST KSS