ID   INCE_CHLT2              Reviewed;         132 AA.
AC   B0B9M4; O84118; Q9RPQ0;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Inclusion membrane protein E {ECO:0000303|PubMed:10447885};
GN   Name=incE {ECO:0000303|PubMed:10447885}; OrderedLocusNames=CTL0371;
OS   Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=471472;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION,
RP   DEVELOPMENTAL STAGE, AND INDUCTION.
RC   STRAIN=434/Bu / ATCC VR-902B;
RX   PubMed=10447885; DOI=10.1046/j.1365-2958.1999.01523.x;
RA   Scidmore-Carlson M.A., Shaw E.I., Dooley C.A., Fischer E.R., Hackstadt T.;
RT   "Identification and characterization of a Chlamydia trachomatis early
RT   operon encoding four novel inclusion membrane proteins.";
RL   Mol. Microbiol. 33:753-765(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=434/Bu / ATCC VR-902B;
RX   PubMed=18032721; DOI=10.1101/gr.7020108;
RA   Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P.,
RA   Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D.,
RA   Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N.;
RT   "Chlamydia trachomatis: genome sequence analysis of lymphogranuloma
RT   venereum isolates.";
RL   Genome Res. 18:161-171(2008).
RN   [3]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=434/Bu / ATCC VR-902B;
RX   PubMed=26416906; DOI=10.1128/iai.01075-15;
RA   Weber M.M., Bauler L.D., Lam J., Hackstadt T.;
RT   "Expression and localization of predicted inclusion membrane proteins in
RT   Chlamydia trachomatis.";
RL   Infect. Immun. 83:4710-4718(2015).
CC   -!- FUNCTION: Inclusion membrane protein probably involved in early
CC       modification events of the chlamydial inclusion.
CC       {ECO:0000305|PubMed:10447885}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:10447885}. Host
CC       vacuole, host pathogen-containing vacuole, host pathogen-containing
CC       vacuole membrane {ECO:0000269|PubMed:10447885,
CC       ECO:0000269|PubMed:26416906}; Multi-pass membrane protein
CC       {ECO:0000255}. Note=Secreted, probably by a type III secretion system
CC       (Probable). Localized in the inclusion membrane (PubMed:10447885,
CC       PubMed:26416906). Inclusion membrane staining is punctate
CC       (PubMed:10447885). {ECO:0000269|PubMed:10447885,
CC       ECO:0000269|PubMed:26416906, ECO:0000305|PubMed:10447885}.
CC   -!- DEVELOPMENTAL STAGE: Present in reticulate bodies (RB) not detected in
CC       elementary bodies (EB) (at protein level).
CC       {ECO:0000269|PubMed:10447885}.
CC   -!- INDUCTION: Cotranscribed with incD, incF and incG within 2 hours after
CC       internalization. {ECO:0000269|PubMed:10447885}.
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DR   EMBL; AF151374; AAD43975.1; -; Genomic_DNA.
DR   EMBL; AM884176; CAP03811.1; -; Genomic_DNA.
DR   RefSeq; WP_009873571.1; NC_010287.1.
DR   RefSeq; YP_001654455.1; NC_010287.1.
DR   AlphaFoldDB; B0B9M4; -.
DR   SMR; B0B9M4; -.
DR   IntAct; B0B9M4; 1.
DR   MINT; B0B9M4; -.
DR   EnsemblBacteria; CAP03811; CAP03811; CTL0371.
DR   KEGG; ctb:CTL0371; -.
DR   PATRIC; fig|471472.4.peg.402; -.
DR   HOGENOM; CLU_1913351_0_0_0; -.
DR   OMA; CAVIVGC; -.
DR   Proteomes; UP000000795; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0140221; C:pathogen-containing vacuole membrane; IDA:UniProtKB.
DR   InterPro; IPR035118; IncE.
DR   Pfam; PF17627; IncE; 1.
PE   1: Evidence at protein level;
KW   Host membrane; Membrane; Secreted; Transmembrane; Transmembrane helix;
KW   Virulence.
FT   CHAIN           1..132
FT                   /note="Inclusion membrane protein E"
FT                   /id="PRO_0000417580"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   132 AA;  13594 MW;  1A4A9FF78B1E6C1E CRC64;
     MECVKQLCRN HLRLDNLTDP VRSVLTKGTT AEKVQLAACC LGVVCSIICL ALGIAAAAVG
     VSCGGFALGL GIIAILLGIV LFATSALDVL ENHGLVGCPF KLPCKSSPAN EPAVQFFKGK
     NGSADQVILV TQ