ID   INCE_CHLTR              Reviewed;         132 AA.
AC   P0DJI4; O84118; Q9RPQ0;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2012, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Inclusion membrane protein E;
GN   Name=incE; OrderedLocusNames=CT_116;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- FUNCTION: Inclusion membrane protein probably involved in early
CC       modification events of the chlamydial inclusion.
CC       {ECO:0000250|UniProtKB:B0B9M4}.
CC   -!- INTERACTION:
CC       P0DJI4; Q9D8U8: Snx5; Xeno; NbExp=4; IntAct=EBI-22303778, EBI-643385;
CC       P0DJI4; Q9UNH7: SNX6; Xeno; NbExp=8; IntAct=EBI-22303778, EBI-949294;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:B0B9M4}. Host
CC       vacuole, host pathogen-containing vacuole, host pathogen-containing
CC       vacuole membrane {ECO:0000250|UniProtKB:B0B9M4}; Multi-pass membrane
CC       protein {ECO:0000255}. Note=Secreted, probably by a type III secretion
CC       system (By similarity). Localized in the inclusion membrane (By
CC       similarity). {ECO:0000250|UniProtKB:B0B9M4}.
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DR   EMBL; AE001273; AAC67707.1; -; Genomic_DNA.
DR   PIR; G71555; G71555.
DR   RefSeq; NP_219619.1; NC_000117.1.
DR   RefSeq; WP_010725071.1; NC_000117.1.
DR   PDB; 5TP1; X-ray; 2.31 A; P/Q/R/S=108-132.
DR   PDBsum; 5TP1; -.
DR   AlphaFoldDB; P0DJI4; -.
DR   SMR; P0DJI4; -.
DR   IntAct; P0DJI4; 42.
DR   MINT; P0DJI4; -.
DR   STRING; 813.O172_00630; -.
DR   EnsemblBacteria; AAC67707; AAC67707; CT_116.
DR   GeneID; 884146; -.
DR   KEGG; ctr:CT_116; -.
DR   PATRIC; fig|272561.5.peg.127; -.
DR   HOGENOM; CLU_1913351_0_0_0; -.
DR   OMA; CAVIVGC; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0140221; C:pathogen-containing vacuole membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR035118; IncE.
DR   Pfam; PF17627; IncE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Host membrane; Membrane; Reference proteome; Secreted;
KW   Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..132
FT                   /note="Inclusion membrane protein E"
FT                   /id="PRO_0000084200"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   STRAND          113..117
FT                   /evidence="ECO:0007829|PDB:5TP1"
FT   STRAND          126..129
FT                   /evidence="ECO:0007829|PDB:5TP1"
SQ   SEQUENCE   132 AA;  13555 MW;  3B6FF7B2D1FE8BDE CRC64;
     MECVKQLCRN HLCLDSLTGP VRSVLTQGTT AEKVQLVVSC LGVVCSIICL ALGIAAAAVG
     VSCSGFAIGL GVIAILLGIV LFAISALDVL EDHGLVGCPF KLPCKSSPAN EPTVQFFKGK
     NGSADKVILV TQ