ID   INCF_CHLT2              Reviewed;         104 AA.
AC   B0B9M5; O84119; Q9RPP9;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Inclusion membrane protein F {ECO:0000303|PubMed:10447885};
GN   Name=incF {ECO:0000303|PubMed:10447885}; OrderedLocusNames=CTL0372;
OS   Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=471472;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION,
RP   DEVELOPMENTAL STAGE, AND INDUCTION.
RC   STRAIN=434/Bu / ATCC VR-902B;
RX   PubMed=10447885; DOI=10.1046/j.1365-2958.1999.01523.x;
RA   Scidmore-Carlson M.A., Shaw E.I., Dooley C.A., Fischer E.R., Hackstadt T.;
RT   "Identification and characterization of a Chlamydia trachomatis early
RT   operon encoding four novel inclusion membrane proteins.";
RL   Mol. Microbiol. 33:753-765(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=434/Bu / ATCC VR-902B;
RX   PubMed=18032721; DOI=10.1101/gr.7020108;
RA   Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P.,
RA   Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D.,
RA   Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N.;
RT   "Chlamydia trachomatis: genome sequence analysis of lymphogranuloma
RT   venereum isolates.";
RL   Genome Res. 18:161-171(2008).
RN   [3]
RP   SUBCELLULAR LOCATION, AND TOPOLOGY.
RC   STRAIN=434/Bu / ATCC VR-902B;
RX   PubMed=11207546; DOI=10.1046/j.1462-5822.1999.00012.x;
RA   Hackstadt T., Scidmore-Carlson M.A., Shaw E.I., Fischer E.R.;
RT   "The Chlamydia trachomatis IncA protein is required for homotypic vesicle
RT   fusion.";
RL   Cell. Microbiol. 1:119-130(1999).
RN   [4]
RP   SUBCELLULAR LOCATION.
RC   STRAIN=434/Bu / ATCC VR-902B;
RX   PubMed=26416906; DOI=10.1128/iai.01075-15;
RA   Weber M.M., Bauler L.D., Lam J., Hackstadt T.;
RT   "Expression and localization of predicted inclusion membrane proteins in
RT   Chlamydia trachomatis.";
RL   Infect. Immun. 83:4710-4718(2015).
CC   -!- FUNCTION: Inclusion membrane protein probably involved in early
CC       modification events of the chlamydial inclusion.
CC       {ECO:0000305|PubMed:10447885}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:10447885}. Host
CC       vacuole, host pathogen-containing vacuole, host pathogen-containing
CC       vacuole membrane {ECO:0000269|PubMed:10447885,
CC       ECO:0000269|PubMed:11207546, ECO:0000269|PubMed:26416906}; Multi-pass
CC       membrane protein {ECO:0000255}. Note=Secreted, probably by a type III
CC       secretion system (Probable). Localized in the inclusion membrane
CC       (PubMed:10447885, PubMed:11207546, PubMed:26416906). Inclusion membrane
CC       staining is punctate (PubMed:10447885). The C-terminus faces the host
CC       cytosol (PubMed:11207546). {ECO:0000269|PubMed:10447885,
CC       ECO:0000269|PubMed:11207546, ECO:0000269|PubMed:26416906,
CC       ECO:0000305|PubMed:10447885}.
CC   -!- DEVELOPMENTAL STAGE: Not detected in reticulate bodies (RB) or in
CC       elementary bodies (EB). {ECO:0000269|PubMed:10447885}.
CC   -!- INDUCTION: Cotranscribed with incD, incE and incG within 2 hours after
CC       internalization. {ECO:0000269|PubMed:10447885}.
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DR   EMBL; AF151374; AAD43976.1; -; Genomic_DNA.
DR   EMBL; AM884176; CAP03812.1; -; Genomic_DNA.
DR   RefSeq; WP_009873572.1; NC_010287.1.
DR   RefSeq; YP_001654456.1; NC_010287.1.
DR   AlphaFoldDB; B0B9M5; -.
DR   EnsemblBacteria; CAP03812; CAP03812; CTL0372.
DR   KEGG; ctb:CTL0372; -.
DR   PATRIC; fig|471472.4.peg.403; -.
DR   HOGENOM; CLU_2380989_0_0_0; -.
DR   OMA; FIESHHR; -.
DR   Proteomes; UP000000795; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0140221; C:pathogen-containing vacuole membrane; IDA:UniProtKB.
DR   InterPro; IPR035119; IncF.
DR   Pfam; PF17626; IncF; 1.
PE   1: Evidence at protein level;
KW   Host membrane; Membrane; Secreted; Transmembrane; Transmembrane helix;
KW   Virulence.
FT   CHAIN           1..104
FT                   /note="Inclusion membrane protein F"
FT                   /id="PRO_0000417581"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   104 AA;  10412 MW;  DD08E42C6B63587D CRC64;
     MGDVMIQSVK TESGLVDGHH GSCDSLGCVV GALAKVAKLV VALAALVLNG ALCVLSLVAL
     CVGATPVGPL AVLVATTLAS FLCVAYVLFI AAKDRGWIAS TNKC