ID   IND12_ECOLI             Reviewed;         307 AA.
AC   P0CF64; P0C5W4; P19777; P76167; P76916; P77033; Q79EJ0;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Transposase InsD for insertion element IS2-12;
GN   OrderedLocusNames=JW5933;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Involved in the transposition of the insertion sequence IS2.
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DR   EMBL; AP009048; BAE77577.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0CF64; -.
DR   PRIDE; P0CF64; -.
DR   EnsemblBacteria; BAE77577; BAE77577; BAE77577.
DR   KEGG; ecj:JW5933; -.
DR   HOGENOM; CLU_052819_0_0_6; -.
DR   PhylomeDB; P0CF64; -.
DR   PRO; PR:P0CF64; -.
DR   Proteomes; UP000000318; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR025948; HTH-like_dom.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF13276; HTH_21; 1.
DR   Pfam; PF00665; rve; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   4: Predicted;
KW   DNA recombination; DNA-binding; Transposable element; Transposition.
FT   CHAIN           1..307
FT                   /note="Transposase InsD for insertion element IS2-12"
FT                   /id="PRO_0000393583"
FT   DOMAIN          112..295
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00457"
SQ   SEQUENCE   307 AA;  35098 MW;  B3F676480E82B309 CRC64;
     MWTGKKVDSA RALIARGWGV SLVSRCLRVS RAQLHVILRR TDDWMDGRRS RHTDDTDVLL
     RIHHVIGELP TYGYRRVWAL LRRQAELDGM PAINAKRVYR IMRQNALLLE RKPAVPPSKR
     AHTGRVAVKE SNQRWCSDGF EFCCDNGERL RVTFALDCCD REALHWAVTT GGFNSETVQD
     VMLGAVERRF GNDLPSSPVE WLTDNGSCYR ANETRQFARM LGLEPKNTAV RSPESNGIAE
     SFVKTIKRDY ISIMPKPDGL TAAKNLAEAF EHYNEWHPHS ALGYRSPREY LRQRACNGLS
     DNRCLEI