ID   INGR1_CARAU             Reviewed;         377 AA.
AC   C8AW46;
DT   10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Interferon gamma receptor 1 {ECO:0000305};
DE   AltName: Full=Interferon gamma receptor 1-1 {ECO:0000303|PubMed:19577303};
DE   Flags: Precursor;
GN   Name=ifngr1 {ECO:0000305}; Synonyms=ifngr1-1 {ECO:0000303|PubMed:19577303};
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957 {ECO:0000312|EMBL:ACV41808.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND INDUCTION.
RX   PubMed=19577303; DOI=10.1016/j.molimm.2009.06.004;
RA   Grayfer L., Belosevic M.;
RT   "Molecular characterization of novel interferon gamma receptor 1 isoforms
RT   in zebrafish (Danio rerio) and goldfish (Carassius auratus L.).";
RL   Mol. Immunol. 46:3050-3059(2009).
CC   -!- FUNCTION: Receptor which shows binding specificity for the cytokine
CC       ifng1r (interferon gamma-related). {ECO:0000269|PubMed:19577303}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:19577303};
CC       Single-pass type I membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in spleen. Also detected in brain,
CC       kidney, gill, intestine and heart. Expressed at very low levels in
CC       muscle. In immune cell populations, shows highest expression in
CC       monocytes, and slightly lower expression in peripheral blood
CC       leukocytes, splenocytes, neutrophils and mature macrophages.
CC       {ECO:0000269|PubMed:19577303}.
CC   -!- INDUCTION: Up-regulated in response to ifng1 (interferon gamma 1),
CC       tgfb1b (TGF-beta), and tnfb (TNF-alpha 2).
CC       {ECO:0000269|PubMed:19577303}.
CC   -!- SIMILARITY: Belongs to the type II cytokine receptor family.
CC       {ECO:0000305}.
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DR   EMBL; GQ149697; ACV41808.1; -; mRNA.
DR   AlphaFoldDB; C8AW46; -.
DR   SMR; C8AW46; -.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   SUPFAM; SSF49265; SSF49265; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Receptor; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..377
FT                   /note="Interferon gamma receptor 1"
FT                   /id="PRO_5002989551"
FT   TOPO_DOM        24..235
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..377
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          26..117
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   REGION          326..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        78
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        186
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   377 AA;  43055 MW;  ADB0773597F770B5 CRC64;
     MRTQIYISVT VLILLLKKSD LEAVRVPSPE SVSVQCDSYG VEARWEYPEV HQDVYFQVKV
     KDEFTERDSS RTKNLHLNIS SMLFRPAYNR YCVTVTAVRG GEKSDPSDFF IFSFNENAAA
     YIKCSLDFPE VELSPKDGRL HVQFTNPLHL YRNSPALRDL SEDLKYCIET DQGKNKVCET
     CQMKQNASCE TSVVFSEHRG EYCFSLTGNI GQRIFNPRSS CFTGDIRRYT PFTVYLYPVL
     GVTLTLLFIT GIIILLEKKC NSEMKKKVPS MFPHFFDFGE TQSHLPKTLC VVADKVEPHL
     QIELVEDPEE QTSLVPLSDN KDLEGVYSED KNSYGPNDLV EDEQSDLSDF YDCPHAPKQK
     REMSPGDTVD SYGPRLL