APOC2_MOUSE
ID APOC2_MOUSE Reviewed; 97 AA.
AC Q05020;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Apolipoprotein C-II;
DE Short=Apo-CII;
DE Short=ApoC-II;
DE AltName: Full=Apolipoprotein C2;
DE Flags: Precursor;
GN Name=Apoc2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=C57BL/RIJ / 129/J; TISSUE=Liver;
RX PubMed=7916738; DOI=10.1006/geno.1993.1010;
RA Hoffer M.J.V., Hofker M.H., van Eck M.M., Havekes L.M., Frants R.R.;
RT "Evolutionary conservation of the mouse apolipoprotein E-C1-C2 gene
RT cluster: structure and genetic variability in inbred mice.";
RL Genomics 15:62-67(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/RIJ;
RX PubMed=7691714; DOI=10.1006/geno.1993.1281;
RA Hoffer M.J.V., van Eck M.M., Havekes L.M., Hofker M.H., Frants R.R.;
RT "Structure and expression of the mouse apolipoprotein C2 gene.";
RL Genomics 17:45-51(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of chylomicrons, very low-density lipoproteins
CC (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins
CC (HDL) in plasma. Plays an important role in lipoprotein metabolism as
CC an activator of lipoprotein lipase. {ECO:0000250|UniProtKB:P02655}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02655}.
CC -!- TISSUE SPECIFICITY: Adult and fetal liver, intestine and peritoneal
CC macrophages. {ECO:0000269|PubMed:7691714}.
CC -!- SIMILARITY: Belongs to the apolipoprotein C2 family. {ECO:0000305}.
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DR EMBL; Z15090; CAA78804.1; -; mRNA.
DR EMBL; Z22216; CAA80220.1; -; Genomic_DNA.
DR EMBL; Z22217; CAA80220.1; JOINED; Genomic_DNA.
DR EMBL; BC024697; AAH24697.1; -; mRNA.
DR CCDS; CCDS39801.1; -.
DR PIR; S31799; S31799.
DR RefSeq; NP_001264873.1; NM_001277944.1.
DR RefSeq; NP_001296724.1; NM_001309795.1.
DR RefSeq; NP_001296728.1; NM_001309799.1.
DR AlphaFoldDB; Q05020; -.
DR SMR; Q05020; -.
DR STRING; 10090.ENSMUSP00000115173; -.
DR iPTMnet; Q05020; -.
DR PhosphoSitePlus; Q05020; -.
DR PaxDb; Q05020; -.
DR PeptideAtlas; Q05020; -.
DR PRIDE; Q05020; -.
DR ProteomicsDB; 296269; -.
DR DNASU; 11813; -.
DR Ensembl; ENSMUST00000003074; ENSMUSP00000003074; ENSMUSG00000002992.
DR Ensembl; ENSMUST00000127648; ENSMUSP00000118305; ENSMUSG00000109350.
DR Ensembl; ENSMUST00000134116; ENSMUSP00000118291; ENSMUSG00000002992.
DR Ensembl; ENSMUST00000142352; ENSMUSP00000115173; ENSMUSG00000002992.
DR Ensembl; ENSMUST00000150569; ENSMUSP00000114512; ENSMUSG00000109350.
DR GeneID; 105886299; -.
DR GeneID; 11813; -.
DR KEGG; mmu:105886299; -.
DR KEGG; mmu:11813; -.
DR UCSC; uc009fmt.3; mouse.
DR CTD; 105886299; -.
DR CTD; 344; -.
DR MGI; MGI:88054; Apoc2.
DR VEuPathDB; HostDB:ENSMUSG00000002992; -.
DR VEuPathDB; HostDB:ENSMUSG00000109350; -.
DR eggNOG; ENOG502SEJB; Eukaryota.
DR GeneTree; ENSGT00390000007913; -.
DR HOGENOM; CLU_180154_0_0_1; -.
DR InParanoid; Q05020; -.
DR OMA; EVQGAHL; -.
DR OrthoDB; 1548460at2759; -.
DR PhylomeDB; Q05020; -.
DR TreeFam; TF338218; -.
DR Reactome; R-MMU-8963888; Chylomicron assembly.
DR Reactome; R-MMU-8963901; Chylomicron remodeling.
DR Reactome; R-MMU-8964058; HDL remodeling.
DR Reactome; R-MMU-975634; Retinoid metabolism and transport.
DR BioGRID-ORCS; 105886299; 0 hits in 2 CRISPR screens.
DR BioGRID-ORCS; 11813; 2 hits in 44 CRISPR screens.
DR ChiTaRS; Apoc2; mouse.
DR PRO; PR:Q05020; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q05020; protein.
DR Bgee; ENSMUSG00000002992; Expressed in yolk sac and 71 other tissues.
DR ExpressionAtlas; Q05020; baseline and differential.
DR Genevisible; Q05020; MM.
DR GO; GO:0042627; C:chylomicron; ISO:MGI.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0034363; C:intermediate-density lipoprotein particle; ISO:MGI.
DR GO; GO:0034362; C:low-density lipoprotein particle; ISO:MGI.
DR GO; GO:0034366; C:spherical high-density lipoprotein particle; ISO:MGI.
DR GO; GO:0034361; C:very-low-density lipoprotein particle; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0055102; F:lipase inhibitor activity; ISO:MGI.
DR GO; GO:0008289; F:lipid binding; ISO:MGI.
DR GO; GO:0060230; F:lipoprotein lipase activator activity; ISO:MGI.
DR GO; GO:0016004; F:phospholipase activator activity; ISO:MGI.
DR GO; GO:0043274; F:phospholipase binding; ISO:MGI.
DR GO; GO:0033344; P:cholesterol efflux; ISO:MGI.
DR GO; GO:0034382; P:chylomicron remnant clearance; ISO:MGI.
DR GO; GO:0034384; P:high-density lipoprotein particle clearance; ISO:MGI.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0032375; P:negative regulation of cholesterol transport; ISO:MGI.
DR GO; GO:0045833; P:negative regulation of lipid metabolic process; ISO:MGI.
DR GO; GO:0048261; P:negative regulation of receptor-mediated endocytosis; ISO:MGI.
DR GO; GO:0010916; P:negative regulation of very-low-density lipoprotein particle clearance; ISO:MGI.
DR GO; GO:0033700; P:phospholipid efflux; ISO:MGI.
DR GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; ISO:MGI.
DR GO; GO:0051006; P:positive regulation of lipoprotein lipase activity; ISO:MGI.
DR GO; GO:0010518; P:positive regulation of phospholipase activity; ISO:MGI.
DR GO; GO:0060697; P:positive regulation of phospholipid catabolic process; ISO:MGI.
DR GO; GO:0010898; P:positive regulation of triglyceride catabolic process; ISO:MGI.
DR GO; GO:0070328; P:triglyceride homeostasis; ISO:MGI.
DR Gene3D; 1.10.1440.10; -; 1.
DR InterPro; IPR008019; Apo-CII.
DR InterPro; IPR023121; ApoC-II_dom_sf.
DR PANTHER; PTHR16566; PTHR16566; 1.
DR Pfam; PF05355; Apo-CII; 1.
PE 2: Evidence at transcript level;
KW Chylomicron; HDL; LDL; Lipid degradation; Lipid metabolism;
KW Lipid transport; Reference proteome; Secreted; Signal; Transport; VLDL.
FT SIGNAL 1..22
FT /evidence="ECO:0000250"
FT CHAIN 23..97
FT /note="Apolipoprotein C-II"
FT /id="PRO_0000002026"
FT REGION 63..71
FT /note="Lipid binding"
FT /evidence="ECO:0000250|UniProtKB:P02655"
FT REGION 75..97
FT /note="Lipoprotein lipase cofactor"
FT /evidence="ECO:0000250|UniProtKB:P02655"
FT CONFLICT 89
FT /note="Q -> H (in Ref. 2; CAA80220)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 97 AA; 10741 MW; 18223E9034A1983E CRC64;
MGSRFFLALF LVILMLGNEV QGNQEDDSGS LALLGTVQGS LLSYWTSAKE VAKDLYQKTY
PISMDEKLRD MYSKSSAAMS TYAGIFTDQL LTLLRGE
