ID   INH1_TABYA              Reviewed;         255 AA.
AC   C1IBY2;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Tabinhibitin 1 {ECO:0000303|PubMed:18087067};
DE   AltName: Full=Macquaritin 1 {ECO:0000312|EMBL:ABX80070.1};
DE   Flags: Precursor;
OS   Tabanus yao (Horsefly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Tabanomorpha; Tabanoidea;
OC   Tabanidae; Tabanus.
OX   NCBI_TaxID=485572;
RN   [1] {ECO:0000312|EMBL:ABX80070.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-48; 88-102 AND 187-202,
RP   SUBCELLULAR LOCATION, AND FUNCTION.
RC   TISSUE=Salivary gland;
RX   PubMed=18087067; DOI=10.1074/mcp.m700497-mcp200;
RA   Xu X., Yang H., Ma D., Wu J., Wang Y., Song Y., Wang X., Lu Y., Yang J.,
RA   Lai R.;
RT   "Toward an understanding of the molecular mechanism for successful blood
RT   feeding by coupling proteomics analysis with pharmacological testing of
RT   horsefly salivary glands.";
RL   Mol. Cell. Proteomics 7:582-590(2008).
CC   -!- FUNCTION: Inhibits platelet aggregation induced by all agonists tested
CC       (By similarity). May act by competing with fibrinogen for binding to
CC       glycoprotein IIb/IIIa (ITGA2B/ITGB3) (By similarity).
CC       {ECO:0000250|UniProtKB:C1IBY3}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18087067}.
CC   -!- TISSUE SPECIFICITY: Expressed in salivary glands.
CC       {ECO:0000305|PubMed:18087067}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; EU147252; ABX80070.1; -; mRNA.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR034763; P14a_insect.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PIRSF; PIRSF038921; P14a; 1.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion impairing toxin; Direct protein sequencing;
KW   Hemostasis impairing toxin; Platelet aggregation inhibiting toxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000305|PubMed:18087067"
FT   CHAIN           24..255
FT                   /note="Tabinhibitin 1"
FT                   /evidence="ECO:0000305|PubMed:18087067"
FT                   /id="PRO_5002908920"
FT   DOMAIN          67..211
FT                   /note="SCP"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        76..77
FT                   /note="Missing (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        154
FT                   /note="L -> LHV (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   255 AA;  28390 MW;  81E40FF098DCA5E9 CRC64;
     MTSILVSRFL IAALVLQYAT SDAVNYCRLP CRGCDYHVGC GEPAYAQECG QSPRTRELLK
     EHRNEILSKI NDVRDHVAKG SWGLPMAARM KVVVWDAELA GLAKRHTKGC VGETHACRNT
     ERFWLPGQLN FKYSGDKLPR IRELIDDAVK KGHLQKHNIT REFIENYREN GPNGNVKGLA
     LAISDRVTAV GCGLTTWEDG AKARALLTCN FSSQNIRGRP VYKIGNSPGE KCIEKDETYK
     NLCSATEPID PNKSN