ID   INH2_TABYA              Reviewed;         255 AA.
AC   C1IBY3;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 1.
DT   03-AUG-2022, entry version 30.
DE   RecName: Full=Tabinhibitin 2 {ECO:0000303|PubMed:18087067};
DE   AltName: Full=Macquaritin 2 {ECO:0000312|EMBL:ABX80071.1};
DE   Flags: Precursor;
OS   Tabanus yao (Horsefly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Tabanomorpha; Tabanoidea;
OC   Tabanidae; Tabanus.
OX   NCBI_TaxID=485572;
RN   [1] {ECO:0000312|EMBL:ABX80071.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-56; 108-133 AND 205-219,
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RC   TISSUE=Salivary gland;
RX   PubMed=18087067; DOI=10.1074/mcp.m700497-mcp200;
RA   Xu X., Yang H., Ma D., Wu J., Wang Y., Song Y., Wang X., Lu Y., Yang J.,
RA   Lai R.;
RT   "Toward an understanding of the molecular mechanism for successful blood
RT   feeding by coupling proteomics analysis with pharmacological testing of
RT   horsefly salivary glands.";
RL   Mol. Cell. Proteomics 7:582-590(2008).
CC   -!- FUNCTION: Inhibits platelet aggregation induced by all agonists tested
CC       (ADP, arachidonic acid, the thromboxane A2 analog U46619, thrombin, and
CC       snake venom snaclecs (TMVA that activates platelet through GPIB, and
CC       stejnulxin that specifically acts through GPVI (GP6)))
CC       (PubMed:18087067). May act by competing with fibrinogen for binding to
CC       glycoprotein IIb/IIIa (ITGA2B/ITGB3) (PubMed:18087067).
CC       {ECO:0000269|PubMed:18087067}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18087067}.
CC   -!- TISSUE SPECIFICITY: Expressed in salivary glands.
CC       {ECO:0000305|PubMed:18087067}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; EU147253; ABX80071.1; -; mRNA.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR034763; P14a_insect.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PIRSF; PIRSF038921; P14a; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion impairing toxin; Direct protein sequencing;
KW   Hemostasis impairing toxin; Platelet aggregation inhibiting toxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255, ECO:0000305|PubMed:18087067"
FT   CHAIN           24..255
FT                   /note="Tabinhibitin 2"
FT                   /evidence="ECO:0000305|PubMed:18087067"
FT                   /id="PRO_5002910541"
FT   DOMAIN          67..211
FT                   /note="SCP"
FT                   /evidence="ECO:0000255"
FT   MOTIF           32..34
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        76..77
FT                   /note="Missing (in Ref. 1)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        154
FT                   /note="L -> LHV (in Ref. 1)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   255 AA;  28390 MW;  3ACC3B44177674C2 CRC64;
     MISILVSRFL LAALVLQYAT IDAVNYCNLP CRGDRFHVGC GESAFAQECG ESPETLDLLK
     EHTDEILSKI NDVRDHVAKG SWGLPMAARM KVVVWDEELA RLATRHTKGC LAETHACRNT
     ERFLFPGQLN FEYTDDKLPQ TKELIDAAIK KGHLQKHNIS REIIESYKDN GPDGDVEELA
     LALSDRVTAV GCGLTTWQDG AKARALLTCN FSSQNIWERP VYKIGNSPGE KCIEKDETYK
     NLCSASEPID SNESN