ID   INH6_TABYA              Reviewed;         254 AA.
AC   C8YJA1;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Tabinhibitin 6 {ECO:0000303|PubMed:19531497};
DE   Flags: Precursor;
OS   Tabanus yao (Horsefly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Tabanomorpha; Tabanoidea;
OC   Tabanidae; Tabanus.
OX   NCBI_TaxID=485572;
RN   [1] {ECO:0000312|EMBL:ACS72296.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 23-50; 122-135; 168-188 AND
RP   204-217, SUBCELLULAR LOCATION, AND FUNCTION.
RC   TISSUE=Salivary gland;
RX   PubMed=19531497; DOI=10.1074/mcp.m900186-mcp200;
RA   Ma D., Wang Y., Yang H., Wu J., An S., Gao L., Xu X., Lai R.;
RT   "Anti-thrombosis repertoire of blood-feeding horsefly salivary glands.";
RL   Mol. Cell. Proteomics 8:2071-2079(2009).
CC   -!- FUNCTION: Inhibits platelet aggregation induced by all agonists tested
CC       (ADP, arachidonic acid, the thromboxane A2 analog U46619, thrombin, and
CC       snake venom snaclecs (TMVA that activates platelet through GPIB, and
CC       stejnulxin that specifically acts through GPVI (GP6)))
CC       (PubMed:19531497). May act by competing with fibrinogen for binding to
CC       glycoprotein IIb/IIIa (ITGA2B/ITGB3) (PubMed:19531497).
CC       {ECO:0000269|PubMed:19531497}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19531497}.
CC   -!- TISSUE SPECIFICITY: Expressed in salivary glands.
CC       {ECO:0000305|PubMed:19531497}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; FJ469608; ACS72296.1; -; mRNA.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR034763; P14a_insect.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PIRSF; PIRSF038921; P14a; 1.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   1: Evidence at protein level;
KW   Cell adhesion impairing toxin; Direct protein sequencing;
KW   Hemostasis impairing toxin; Platelet aggregation inhibiting toxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255, ECO:0000305|PubMed:19531497"
FT   CHAIN           23..254
FT                   /note="Tabinhibitin 6"
FT                   /evidence="ECO:0000305|PubMed:19531497"
FT                   /id="PRO_5002994255"
FT   DOMAIN          66..210
FT                   /note="SCP"
FT                   /evidence="ECO:0000255"
FT   MOTIF           31..33
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000305|PubMed:19531497"
SQ   SEQUENCE   254 AA;  28300 MW;  07FCB78F3C83FEE4 CRC64;
     MLPYWCPLLL AALVLQYATI DAVNYCNLPC RGDRFHVGCG ESAFAQECGE SPETLDLLKE
     HTDEILSKIN DVRDHVAKGS WGLPMAARMK VVVWDEELAR LATRHTKGCL AETHACRNTE
     RFLFPGQLNF EYTDDKLPQT KELIDAAIKK GHLQKHNISR EIIESYRDNG PDGNVEELAL
     ALSDRVTAVG CGLTTWQDGA KARALLTCNF SSQNTWGRPV YKIGNSPGEK CIEKDETYKN
     LCSASEPIDP NESN