ID   INH9_TABYA              Reviewed;         252 AA.
AC   C8YJG4;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 24.
DE   RecName: Full=Tabinhibitin 9 {ECO:0000303|PubMed:19531497};
DE   Flags: Precursor;
OS   Tabanus yao (Horsefly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Tabanomorpha; Tabanoidea;
OC   Tabanidae; Tabanus.
OX   NCBI_TaxID=485572;
RN   [1] {ECO:0000312|EMBL:ACT33296.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Salivary gland;
RX   PubMed=19531497; DOI=10.1074/mcp.m900186-mcp200;
RA   Ma D., Wang Y., Yang H., Wu J., An S., Gao L., Xu X., Lai R.;
RT   "Anti-thrombosis repertoire of blood-feeding horsefly salivary glands.";
RL   Mol. Cell. Proteomics 8:2071-2079(2009).
CC   -!- FUNCTION: Inhibits platelet aggregation induced by all agonists tested
CC       (ADP, arachidonic acid, the thromboxane A2 analog U46619, thrombin, and
CC       snake venom snaclecs (TMVA that activates platelet through GPIB, and
CC       stejnulxin that specifically acts through GPVI (GP6))) (By similarity).
CC       May act by competing with fibrinogen for binding to glycoprotein
CC       IIb/IIIa (ITGA2B/ITGB3) (By similarity).
CC       {ECO:0000250|UniProtKB:C8YJA0}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:C1IBY3}.
CC   -!- TISSUE SPECIFICITY: Expressed in salivary glands.
CC       {ECO:0000250|UniProtKB:C1IBY3}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
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DR   EMBL; FJ477725; ACT33296.1; -; mRNA.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion impairing toxin; Hemostasis impairing toxin;
KW   Platelet aggregation inhibiting toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250|UniProtKB:C8YJA0"
FT   CHAIN           24..252
FT                   /note="Tabinhibitin 9"
FT                   /evidence="ECO:0000250|UniProtKB:C8YJA0"
FT                   /id="PRO_0000456096"
FT   DOMAIN          63..207
FT                   /note="SCP"
FT                   /evidence="ECO:0000250|UniProtKB:C8YJA0"
FT   MOTIF           32..34
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000305|PubMed:19531497"
SQ   SEQUENCE   252 AA;  28855 MW;  B216FF254184CDD4 CRC64;
     MTSNLYYVLI SPYSLAYMVQ YRSVTTAAGE CRGDMWAVCA RISSDVTCAR HANLQRSIRR
     CFYIRSTMCE IMLLRDHGDY PVASRMKVIV WDEELAALAK RHTQGCVPEA YKCRHTLRFW
     TPGQLNFEFY ADKMPFTMSL ISTAIKRGHM QKHNITRDIV EKYQPVGPKG NVKELALAIF
     DRVTAVGCGL TTWKLGGKAR AFFTCNFFSE NDYNRPVYKT GNSPGEKCIK KDETFKNLCF
     AQEPINPNEH NL