INHBC_MOUSE
ID INHBC_MOUSE Reviewed; 352 AA.
AC P55104; Q61452;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Inhibin beta C chain;
DE AltName: Full=Activin beta-C chain;
DE Flags: Precursor;
GN Name=Inhbc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=129; TISSUE=Liver;
RX PubMed=8838799; DOI=10.1006/geno.1996.0130;
RA Schmitt J., Hoetten G., Jenkins N.A., Gilbert D.J., Copeland N.G., Pohl J.,
RA Schrewe H.;
RT "Structure, chromosomal localization, and expression analysis of the mouse
RT inhibin/activin beta C (Inhbc) gene.";
RL Genomics 32:358-366(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8679697; DOI=10.1016/0167-4781(96)00061-9;
RA Lau A.L., Nishimori K., Matzuk M.M.;
RT "Structural analysis of the mouse activin beta C gene.";
RL Biochim. Biophys. Acta 1307:145-148(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9070865; DOI=10.1006/bbrc.1997.6162;
RA Fang J., Wang S.Q., Smiley E., Bonadio J.;
RT "Genes coding for mouse activin beta C and beta E are closely linked and
RT exhibit a liver-specific expression pattern in adult tissues.";
RL Biochem. Biophys. Res. Commun. 231:655-661(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Inhibins and activins inhibit and activate, respectively, the
CC secretion of follitropin by the pituitary gland. Inhibins/activins are
CC involved in regulating a number of diverse functions such as
CC hypothalamic and pituitary hormone secretion, gonadal hormone
CC secretion, germ cell development and maturation, erythroid
CC differentiation, insulin secretion, nerve cell survival, embryonic
CC axial development or bone growth, depending on their subunit
CC composition. Inhibins appear to oppose the functions of activins.
CC -!- SUBUNIT: Homodimeric or heterodimeric through association with alpha
CC and beta subunits, linked by one or more disulfide bonds. Inhibins are
CC heterodimers of one alpha and one beta subunit. Activins are homo- or
CC heterodimers of beta subunits only (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Mainly expressed in the adult liver.
CC -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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DR EMBL; X90841; CAA62347.1; -; Genomic_DNA.
DR EMBL; X90842; CAA62347.1; JOINED; Genomic_DNA.
DR EMBL; X90819; CAA62333.1; -; mRNA.
DR EMBL; U40773; AAC52723.1; -; Genomic_DNA.
DR EMBL; U40772; AAC52723.1; JOINED; Genomic_DNA.
DR EMBL; U95962; AAC53164.1; -; mRNA.
DR EMBL; BC026140; AAH26140.1; -; mRNA.
DR CCDS; CCDS24240.1; -.
DR PIR; JC5366; JC5366.
DR PIR; S70580; S70580.
DR RefSeq; NP_034695.1; NM_010565.4.
DR AlphaFoldDB; P55104; -.
DR SMR; P55104; -.
DR STRING; 10090.ENSMUSP00000026472; -.
DR GlyGen; P55104; 4 sites.
DR iPTMnet; P55104; -.
DR PhosphoSitePlus; P55104; -.
DR MaxQB; P55104; -.
DR PaxDb; P55104; -.
DR PeptideAtlas; P55104; -.
DR PRIDE; P55104; -.
DR ProteomicsDB; 269485; -.
DR Antibodypedia; 28599; 319 antibodies from 29 providers.
DR DNASU; 16325; -.
DR Ensembl; ENSMUST00000026472; ENSMUSP00000026472; ENSMUSG00000025405.
DR GeneID; 16325; -.
DR KEGG; mmu:16325; -.
DR UCSC; uc007hjj.2; mouse.
DR CTD; 3626; -.
DR MGI; MGI:105932; Inhbc.
DR VEuPathDB; HostDB:ENSMUSG00000025405; -.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000160065; -.
DR HOGENOM; CLU_020515_5_1_1; -.
DR InParanoid; P55104; -.
DR OMA; GLSTINQ; -.
DR OrthoDB; 1385831at2759; -.
DR PhylomeDB; P55104; -.
DR TreeFam; TF351791; -.
DR Reactome; R-MMU-209822; Glycoprotein hormones.
DR BioGRID-ORCS; 16325; 2 hits in 73 CRISPR screens.
DR PRO; PR:P55104; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; P55104; protein.
DR Bgee; ENSMUSG00000025405; Expressed in liver and 4 other tissues.
DR Genevisible; P55104; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
DR GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001318; Inhibin_betaC.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; PTHR11848; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PRINTS; PR00672; INHIBINBC.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW Growth factor; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..236
FT /evidence="ECO:0000255"
FT /id="PRO_0000033732"
FT CHAIN 237..352
FT /note="Inhibin beta C chain"
FT /id="PRO_0000033733"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 173
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 240..248
FT /evidence="ECO:0000250"
FT DISULFID 247..317
FT /evidence="ECO:0000250"
FT DISULFID 276..349
FT /evidence="ECO:0000250"
FT DISULFID 280..351
FT /evidence="ECO:0000250"
FT DISULFID 316
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT CONFLICT 243
FT /note="A -> G (in Ref. 1; CAA62347/CAA62333)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 352 AA; 39401 MW; 220812FD73717185 CRC64;
MASSLLLALL FLTPTTVVNP KTEGPCPACW GAIFDLESQR ELLLDLAKKS ILDKLHLSQR
PILSRPVSRG ALKTALQRLR GPRRETLLEH DQRQEEYEII SFADTDLSSI NQTRLEFHFS
GRMASGMEVR QTRFMFFVQF PHNATQTMNI RVLVLRPYDT NLTLTSQYVV QVNASGWYQL
LLGPEAQAAC SQGHLTLELV PESQVAHSSL ILGWFSHRPF VAAQVRVEGK HRVRRRGIDC
QGASRMCCRQ EFFVDFREIG WNDWIIQPEG YAMNFCTGQC PLHVAGMPGI SASFHTAVLN
LLKANAAAGT TGRGSCCVPT SRRPLSLLYY DRDSNIVKTD IPDMVVEACG CS
