INHBE_MOUSE
ID INHBE_MOUSE Reviewed; 350 AA.
AC O08717; Q91XH3;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Inhibin beta E chain;
DE AltName: Full=Activin beta-E chain;
DE Flags: Precursor;
GN Name=Inhbe;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=8941337; DOI=10.1006/bbrc.1996.1715;
RA Fang J., Yin W., Smiley E., Wang S.Q., Bonadio J.;
RT "Molecular cloning of the mouse activin beta E subunit gene.";
RL Biochem. Biophys. Res. Commun. 228:669-674(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9070865; DOI=10.1006/bbrc.1997.6162;
RA Fang J., Wang S.Q., Smiley E., Bonadio J.;
RT "Genes coding for mouse activin beta C and beta E are closely linked and
RT exhibit a liver-specific expression pattern in adult tissues.";
RL Biochem. Biophys. Res. Commun. 231:655-661(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Inhibins and activins inhibit and activate, respectively, the
CC secretion of follitropin by the pituitary gland. Inhibins/activins are
CC involved in regulating a number of diverse functions such as
CC hypothalamic and pituitary hormone secretion, gonadal hormone
CC secretion, germ cell development and maturation, erythroid
CC differentiation, insulin secretion, nerve cell survival, embryonic
CC axial development or bone growth, depending on their subunit
CC composition. Inhibins appear to oppose the functions of activins.
CC -!- SUBUNIT: Homodimeric or heterodimeric through association with alpha
CC and beta subunits, linked by one or more disulfide bonds. Inhibins are
CC heterodimers of one alpha and one beta subunit. Activins are homo- or
CC heterodimers of beta subunits only (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: First expression in embryonic liver is detected at
CC 17.5 dpc.
CC -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
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DR EMBL; U96386; AAB53801.1; -; mRNA.
DR EMBL; CH466578; EDL24502.1; -; Genomic_DNA.
DR EMBL; BC010404; AAH10404.1; -; mRNA.
DR CCDS; CCDS24239.1; -.
DR PIR; JC5241; JC5241.
DR RefSeq; NP_032408.2; NM_008382.3.
DR AlphaFoldDB; O08717; -.
DR SMR; O08717; -.
DR STRING; 10090.ENSMUSP00000053977; -.
DR GlyGen; O08717; 1 site.
DR iPTMnet; O08717; -.
DR PhosphoSitePlus; O08717; -.
DR MaxQB; O08717; -.
DR PaxDb; O08717; -.
DR PRIDE; O08717; -.
DR ProteomicsDB; 267139; -.
DR Antibodypedia; 16213; 136 antibodies from 19 providers.
DR DNASU; 16326; -.
DR Ensembl; ENSMUST00000059718; ENSMUSP00000053977; ENSMUSG00000047492.
DR GeneID; 16326; -.
DR KEGG; mmu:16326; -.
DR UCSC; uc011xps.1; mouse.
DR CTD; 83729; -.
DR MGI; MGI:109269; Inhbe.
DR VEuPathDB; HostDB:ENSMUSG00000047492; -.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000162107; -.
DR HOGENOM; CLU_020515_5_0_1; -.
DR InParanoid; O08717; -.
DR OMA; ETPLCCR; -.
DR OrthoDB; 1385831at2759; -.
DR PhylomeDB; O08717; -.
DR TreeFam; TF318514; -.
DR Reactome; R-MMU-209822; Glycoprotein hormones.
DR BioGRID-ORCS; 16326; 2 hits in 75 CRISPR screens.
DR ChiTaRS; Inhbe; mouse.
DR PRO; PR:O08717; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; O08717; protein.
DR Bgee; ENSMUSG00000047492; Expressed in hepatobiliary system and 15 other tissues.
DR Genevisible; O08717; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
DR GO; GO:0060395; P:SMAD protein signal transduction; IBA:GO_Central.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001318; Inhibin_betaC.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; PTHR11848; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PRINTS; PR00672; INHIBINBC.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW Growth factor; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT PROPEP 22..236
FT /evidence="ECO:0000255"
FT /id="PRO_0000033738"
FT CHAIN 237..350
FT /note="Inhibin beta E chain"
FT /id="PRO_0000033739"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 240..248
FT /evidence="ECO:0000250"
FT DISULFID 247..315
FT /evidence="ECO:0000250"
FT DISULFID 276..347
FT /evidence="ECO:0000250"
FT DISULFID 280..349
FT /evidence="ECO:0000250"
FT DISULFID 314
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT CONFLICT 22
FT /note="T -> R (in Ref. 1; AAB53801)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 350 AA; 39002 MW; 9B7EA8AFFAC389FA CRC64;
MKLPKAQLWL ILLWALVWVQ STRSACPSCG GPTLAPQGER ALVLELAKQQ ILEGLHLTSR
PRITRPLPQA ALTRALRRLQ PKSMVPGNRE KVISFATIID KSTSTYRSML TFQLSPLWSH
HLYHARLWLH VPPSFPGTLY LRIFRCGTTR CRGFRTFLAE HQTTSSGWHA LTLPSSGLRS
EDSGVVKLQL EFRPLDLNST AAGLPRLLLD TAGQQRPFLE LKIRANEPGA GRARRRTPTC
EPETPLCCRR DHYVDFQELG WRDWILQPEG YQLNYCSGQC PPHLAGSPGI AASFHSAVFS
LLKANNPWPA GSSCCVPTAR RPLSLLYLDH NGNVVKTDVP DMVVEACGCS
