INH_PHOLU
ID INH_PHOLU Reviewed; 134 AA.
AC Q84F69;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2004, sequence version 2.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Alkaline proteinase inhibitor;
DE AltName: Full=PrtA-specific inhibitor;
DE Flags: Precursor;
GN Name=inh; Synonyms=prtI;
OS Photorhabdus luminescens (Xenorhabdus luminescens).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Photorhabdus.
OX NCBI_TaxID=29488;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=W14;
RA Waterfield N.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibitor of the alkaline protease. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I38 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO39139.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY230750; AAO39139.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_036781577.1; NZ_JXUR02000194.1.
DR AlphaFoldDB; Q84F69; -.
DR SMR; Q84F69; -.
DR STRING; 29488.KS18_15940; -.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR InterPro; IPR022815; Inh.
DR InterPro; IPR021140; Inh/Omp19.
DR InterPro; IPR016085; Protease_inh_b-brl_dom.
DR Pfam; PF02974; Inh; 1.
DR PRINTS; PR01274; MPTASEINHBTR.
DR SUPFAM; SSF50882; SSF50882; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Metalloenzyme inhibitor; Metalloprotease inhibitor;
KW Periplasm; Protease inhibitor; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..134
FT /note="Alkaline proteinase inhibitor"
FT /id="PRO_0000026716"
FT DISULFID 50..73
FT /evidence="ECO:0000250"
SQ SEQUENCE 134 AA; 14795 MW; 8F4B3884EEE72E25 CRC64;
MVFAAWYLKF AFFVALAFSI IGGSMASSLV LPHASELKGV WQLSDKHQQC DVSLTDQPLP
EGSIWSLNGD NDCLAYMFGE VPAGWRPTPD GLTITDEQGS GLAFFANEPD GWFARFADGR
ELMMKPNKTN KKNE