ID   INH_SERMA               Reviewed;         124 AA.
AC   Q54478;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Alkaline proteinase inhibitor;
DE   AltName: Full=11 kDa protease inhibitor;
DE   AltName: Full=SmaPI;
DE   Flags: Precursor;
GN   Name=inh;
OS   Serratia marcescens.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Serratia.
OX   NCBI_TaxID=615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RC   STRAIN=ATCC 27117 / D 217;
RX   PubMed=7487035; DOI=10.1128/aem.61.8.3035-3041.1995;
RA   Kim K.S., Kim T.U., Kim I.J., Byun S.M., Shin Y.C.;
RT   "Characterization of a metalloprotease inhibitor protein (SmaPI) of
RT   Serratia marcescens.";
RL   Appl. Environ. Microbiol. 61:3035-3041(1995).
CC   -!- FUNCTION: Inhibitor of the alkaline protease. Inhibits SMP by formation
CC       of a non-covalent complex with a molar ratio of 1:1 and shows a high
CC       specificity.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I38 family.
CC       {ECO:0000305}.
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DR   EMBL; L09107; AAA92336.1; -; Genomic_DNA.
DR   PIR; S55042; S55042.
DR   AlphaFoldDB; Q54478; -.
DR   SMR; Q54478; -.
DR   STRING; 273526.SMDB11_4312; -.
DR   MEROPS; I38.003; -.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   InterPro; IPR022815; Inh.
DR   InterPro; IPR021140; Inh/Omp19.
DR   InterPro; IPR016085; Protease_inh_b-brl_dom.
DR   Pfam; PF02974; Inh; 1.
DR   PRINTS; PR01274; MPTASEINHBTR.
DR   SUPFAM; SSF50882; SSF50882; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Metalloenzyme inhibitor; Metalloprotease inhibitor;
KW   Periplasm; Protease inhibitor; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..124
FT                   /note="Alkaline proteinase inhibitor"
FT                   /id="PRO_0000026721"
FT   DISULFID        47..70
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   124 AA;  12883 MW;  7C1707BAD8C39B68 CRC64;
     MKGTLTRAAL AAGGMMVTSA VMAGSLALPT AQSLAGQWEV ADSERQCQIE FLANEQSETN
     GYQLVDRQRC LQSVFAAEVV AGAGPDGIAL LQADGSTLAF FSRDGDLYRN QLGAGDALTL
     KALA