ID   INIA_MYCTO              Reviewed;         640 AA.
AC   P9WJ98; L0T6D8; O06293; Q7D9Z6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Isoniazid-induced protein IniA;
GN   Name=iniA; OrderedLocusNames=MT0357;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Participates in the development of tolerance to both
CC       isoniazid and ethambutol. May function through a MDR-pump like
CC       mechanism, although it does not appear to directly transport isoniazid
CC       from the cell (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms multimeric structures containing a central pore.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AE000516; AAK44579.1; -; Genomic_DNA.
DR   PIR; G70573; G70573.
DR   RefSeq; WP_003900124.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJ98; -.
DR   SMR; P9WJ98; -.
DR   EnsemblBacteria; AAK44579; AAK44579; MT0357.
DR   KEGG; mtc:MT0357; -.
DR   PATRIC; fig|83331.31.peg.377; -.
DR   HOGENOM; CLU_019977_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Coiled coil; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..640
FT                   /note="Isoniazid-induced protein IniA"
FT                   /id="PRO_0000427867"
FT   TRANSMEM        497..519
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          560..628
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   640 AA;  70083 MW;  3A28E3E82C528F44 CRC64;
     MVPAGLCAYR DLRRKRARKW GDTVTQPDDP RRVGVIVELI DHTIAIAKLN ERGDLVQRLT
     RARQRITDPQ VRVVIAGLLK QGKSQLLNSL LNLPAARVGD DEATVVITVV SYSAQPSARL
     VLAAGPDGTT AAVDIPVDDI STDVRRAPHA GGREVLRVEV GAPSPLLRGG LAFIDTPGVG
     GLGQPHLSAT LGLLPEADAV LVVSDTSQEF TEPEMWFVRQ AHQICPVGAV VATKTDLYPR
     WREIVNANAA HLQRARVPMP IIAVSSLLRS HAVTLNDKEL NEESNFPAIV KFLSEQVLSR
     ATERVRAGVL GEIRSATEQL AVSLGSELSV VNDPNLRDRL ASDLERRKRE AQQAVQQTAL
     WQQVLGDGFN DLTADVDHDL RTRFRTVTED AERQIDSCDP TAHWAEIGND VENAIATAVG
     DNFVWAYQRS EALADDVARS FADAGLDSVL SAELSPHVMG TDFGRLKALG RMESKPLRRG
     HKMIIGMRGS YGGVVMIGML SSVVGLGLFN PLSVGAGLIL GRMAYKEDKQ NRLLRVRSEA
     KANVRRFVDD ISFVVSKQSR DRLKMIQRLL RDHYREIAEE ITRSLTESLQ ATIAAAQVAE
     TERDNRIREL QRQLGILSQV NDNLAGLEPT LTPRASLGRA