ID   INIB_MYCTU              Reviewed;         479 AA.
AC   P9WJ97; L0T3D4; O06292; Q8VKM5;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Isoniazid-induced protein IniB;
GN   Name=iniB; OrderedLocusNames=Rv0341;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION.
RX   PubMed=10714983; DOI=10.1128/jb.182.7.1802-1811.2000;
RA   Alland D., Steyn A.J., Weisbrod T., Aldrich K., Jacobs W.R. Jr.;
RT   "Characterization of the Mycobacterium tuberculosis iniBAC promoter, a
RT   promoter that responds to cell wall biosynthesis inhibition.";
RL   J. Bacteriol. 182:1802-1811(2000).
RN   [3]
RP   INDUCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=17590082; DOI=10.1371/journal.ppat.0030087;
RA   Colangeli R., Helb D., Vilcheze C., Hazbon M.H., Lee C.G., Safi H.,
RA   Sayers B., Sardone I., Jones M.B., Fleischmann R.D., Peterson S.N.,
RA   Jacobs W.R. Jr., Alland D.;
RT   "Transcriptional regulation of multi-drug tolerance and antibiotic-induced
RT   responses by the histone-like protein Lsr2 in M. tuberculosis.";
RL   PLoS Pathog. 3:E87-E87(2007).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- INDUCTION: Specifically induced by a broad range of inhibitors of cell
CC       wall biosynthesis, including antibiotics that inhibit the synthesis of
CC       peptidoglycan (ampicillin), arabinogalactam (ethambutol), mycolic acids
CC       (isoniazid, ethionamide) and fatty acids (5-chloropyrazinamide). Down-
CC       regulated by the nucleoid-associated protein Lsr2.
CC       {ECO:0000269|PubMed:10714983, ECO:0000269|PubMed:17590082}.
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DR   EMBL; AL123456; CCP43071.1; -; Genomic_DNA.
DR   PIR; F70573; F70573.
DR   RefSeq; NP_214855.1; NC_000962.3.
DR   RefSeq; WP_003901837.1; NZ_KK339370.1.
DR   AlphaFoldDB; P9WJ97; -.
DR   STRING; 83332.Rv0341; -.
DR   TCDB; 9.B.282.1.1; the isoniazid-resistance (iniabc) family.
DR   PaxDb; P9WJ97; -.
DR   DNASU; 886518; -.
DR   GeneID; 45424307; -.
DR   GeneID; 886518; -.
DR   KEGG; mtu:Rv0341; -.
DR   PATRIC; fig|83332.111.peg.377; -.
DR   TubercuList; Rv0341; -.
DR   eggNOG; ENOG5032WSK; Bacteria.
DR   OMA; WAPTWAP; -.
DR   Proteomes; UP000001584; Chromosome.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..479
FT                   /note="Isoniazid-induced protein IniB"
FT                   /id="PRO_0000390792"
FT   REGION          416..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   479 AA;  43921 MW;  CFD0CFF81302828D CRC64;
     MTSLIDYILS LFRSEDAARS FVAAPGRAMT SAGLIDIAPH QISSVAANVV PGLNLGAGDP
     MSGLRQAVAA RHGFAQDVAN VGFAGDAGAG VASVITTDVG AGLASGLGAG FLGQGGLALA
     ASSGGFGGQV GLAAQVGLGF TAVIEAEVGA QVGAGLGIGT GLGAQAGMGF GGGVGLGLGG
     QAGGVIGGSA AGAIGAGVGG RLGGNGQIGV AGQGAVGAGV GAGVGGQAGI ASQIGVSAGG
     GLGGVGNVSG LTGVSSNAVL ASNASGQAGL IASEGAALNG AAMPHLSGPL AGVGVGGQAG
     AAGGAGLGFG AVGHPTPQPA ALGAAGVVAK TEAAAGVVGG VGGATAAGVG GAHGDILGHE
     GAALGSVDTV NAGVTPVEHG LVLPSGPLIH GGTGGYGGMN PPVTDAPAPQ VPARAQPMTT
     AAEHTPAVTQ PQHTPVEPPV HDKPPSHSVF DVGHEPPVTH TPPAPIELPS YGLFGLPGF