ID   INIC_MYCTU              Reviewed;         493 AA.
AC   P9WJ95; L0T663; O06294; Q7D9Z5;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Isoniazid-induced protein IniC;
GN   Name=iniC; OrderedLocusNames=Rv0343;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION.
RX   PubMed=10714983; DOI=10.1128/jb.182.7.1802-1811.2000;
RA   Alland D., Steyn A.J., Weisbrod T., Aldrich K., Jacobs W.R. Jr.;
RT   "Characterization of the Mycobacterium tuberculosis iniBAC promoter, a
RT   promoter that responds to cell wall biosynthesis inhibition.";
RL   J. Bacteriol. 182:1802-1811(2000).
RN   [3]
RP   INDUCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=17590082; DOI=10.1371/journal.ppat.0030087;
RA   Colangeli R., Helb D., Vilcheze C., Hazbon M.H., Lee C.G., Safi H.,
RA   Sayers B., Sardone I., Jones M.B., Fleischmann R.D., Peterson S.N.,
RA   Jacobs W.R. Jr., Alland D.;
RT   "Transcriptional regulation of multi-drug tolerance and antibiotic-induced
RT   responses by the histone-like protein Lsr2 in M. tuberculosis.";
RL   PLoS Pathog. 3:E87-E87(2007).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- INDUCTION: Specifically induced by a broad range of inhibitors of cell
CC       wall biosynthesis, including antibiotics that inhibit the synthesis of
CC       peptidoglycan (ampicillin), arabinogalactam (ethambutol), mycolic acids
CC       (isoniazid, ethionamide) and fatty acids (5-chloropyrazinamide). Down-
CC       regulated by the nucleoid-associated protein Lsr2.
CC       {ECO:0000269|PubMed:10714983, ECO:0000269|PubMed:17590082}.
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DR   EMBL; AL123456; CCP43073.1; -; Genomic_DNA.
DR   PIR; H70573; H70573.
DR   RefSeq; NP_214857.1; NC_000962.3.
DR   RefSeq; WP_003401747.1; NZ_NVQJ01000002.1.
DR   AlphaFoldDB; P9WJ95; -.
DR   STRING; 83332.Rv0343; -.
DR   TCDB; 9.B.282.1.1; the isoniazid-resistance (iniabc) family.
DR   PaxDb; P9WJ95; -.
DR   DNASU; 886508; -.
DR   GeneID; 45424309; -.
DR   GeneID; 886508; -.
DR   KEGG; mtu:Rv0343; -.
DR   TubercuList; Rv0343; -.
DR   eggNOG; COG0699; Bacteria.
DR   OMA; EPAYRQR; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR045063; Dynamin_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00350; Dynamin_N; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..493
FT                   /note="Isoniazid-induced protein IniC"
FT                   /id="PRO_0000390793"
SQ   SEQUENCE   493 AA;  53019 MW;  B3F8D0448ECA5055 CRC64;
     MSTSDRVRAI LHATIQAYRG APAYRQRGDV FCQLDRIGAR LAEPLRIALA GTLKAGKSTL
     VNALVGDDIA PTDATEATRI VTWFRHGPTP RVTANHRGGR RANVPITRRG GLSFDLRRIN
     PAELIDLEVE WPAEELIDAT IVDTPGTSSL ACDASERTLR LLVPADGVPR VDAVVFLLRT
     LNAADVALLK QIGGLVGGSV GALGIIGVAS RADEIGAGRI DAMLSANDVA KRFTRELNQM
     GICQAVVPVS GLLALTARTL RQTEFIALRK LAGAERTELN RALLSVDRFV RRDSPLPVDA
     GIRAQLLERF GMFGIRMSIA VLAAGVTDST GLAAELLERS GLVALRNVID QQFAQRSDML
     KAHTALVSLR RFVQTHPVPA TPYVIADIDP LLADTHAFEE LRMLSLLPSR ATTLNDDEIA
     SLRRIIGGSG TSAAARLGLD PANSREAPRA ALAAAQHWRR RAAHPLNDPF TTRACRAAVR
     SAEAMVAEFS ARR