INK1B_DANRE
ID INK1B_DANRE Reviewed; 288 AA.
AC F1QPR4; Q7SXD0;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 49.
DE RecName: Full=PAK4-inhibitor inka2 {ECO:0000305};
DE AltName: Full=Induced in neural crest by AP2-alpha protein 2 {ECO:0000303|PubMed:17314132};
DE Short=zinca2 {ECO:0000303|PubMed:17314132};
GN Name=fam212ab {ECO:0000312|ZFIN:ZDB-GENE-030131-5539}; Synonyms=inka1b;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP IDENTIFICATION.
RX PubMed=17314132; DOI=10.1242/dev.02813;
RA Luo T., Xu Y., Hoffman T.L., Zhang T., Schilling T., Sargent T.D.;
RT "Inca: a novel p21-activated kinase-associated protein required for cranial
RT neural crest development.";
RL Development 134:1279-1289(2007).
CC -!- FUNCTION: Inhibitor of the serine/threonine-protein kinase pak4/pak5.
CC Acts by binding pak4/pak5 in a substrate-like manner, inhibiting the
CC protein kinase activity. {ECO:0000250|UniProtKB:Q96EL1}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NTI7}.
CC -!- DOMAIN: The Inka box (also named iBox or inca box) binds and inhibits
CC PAK4 by binding a substrate-like manner.
CC {ECO:0000250|UniProtKB:Q96EL1}.
CC -!- SIMILARITY: Belongs to the INKA family. {ECO:0000305}.
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DR EMBL; CU468828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC055656; AAH55656.1; -; mRNA.
DR RefSeq; NP_956082.1; NM_199788.1.
DR AlphaFoldDB; F1QPR4; -.
DR STRING; 7955.ENSDARP00000094044; -.
DR PaxDb; F1QPR4; -.
DR Ensembl; ENSDART00000103267; ENSDARP00000094044; ENSDARG00000070404.
DR GeneID; 327328; -.
DR KEGG; dre:327328; -.
DR CTD; 327328; -.
DR ZFIN; ZDB-GENE-030131-5539; inka1b.
DR eggNOG; ENOG502QYBJ; Eukaryota.
DR GeneTree; ENSGT00530000063849; -.
DR HOGENOM; CLU_077157_0_0_1; -.
DR InParanoid; F1QPR4; -.
DR OMA; MQSMMRS; -.
DR OrthoDB; 1263048at2759; -.
DR TreeFam; TF332839; -.
DR PRO; PR:F1QPR4; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 6.
DR Bgee; ENSDARG00000070404; Expressed in ovary and 45 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; ISS:UniProtKB.
DR InterPro; IPR029267; FAM212.
DR InterPro; IPR039201; Inka.
DR PANTHER; PTHR28615; PTHR28615; 1.
DR Pfam; PF15342; FAM212; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome.
FT CHAIN 1..288
FT /note="PAK4-inhibitor inka2"
FT /id="PRO_0000438818"
FT REGION 159..196
FT /note="Inka box"
FT /evidence="ECO:0000250|UniProtKB:Q96EL1"
FT CONFLICT 215
FT /note="M -> K (in Ref. 2; AAH55656)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 288 AA; 32880 MW; 38821F666C896234 CRC64;
MLCVRNSGEC FRDHMRHMMR SLQDLKQIRE PDDQSKCSYV TRARQKRIKQ REQLSRLRIS
DVSDTSTYDS ACCLASPLEE EEDQENHAER LAQGSPSSIK SLDFDSGYSE ASWQDEGVVL
RRTRNVRVSS SACVRTNRIR PKSTSDACLE RWTSFEASDP TDWTTSLLTR GRNRQPLVLG
DNSFADLIKN WMDLPECPDS AELKPSRKTA FLVNMRRKIA GISKGLEERR SAEAKRMSCP
VGFQPPKPFF HQSHTSLHPM GTDFYQFSSV MKSGSRQPII CNDVIGYI
