ID   INKA2_BOVIN             Reviewed;         294 AA.
AC   A6QP24;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=PAK4-inhibitor INKA2 {ECO:0000305};
GN   Name=INKA2 {ECO:0000250|UniProtKB:Q9NTI7};
GN   Synonyms=FAM212B {ECO:0000250|UniProtKB:Q9NTI7};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Basal ganglia;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibitor of the serine/threonine-protein kinase PAK4. Acts
CC       by binding PAK4 in a substrate-like manner, inhibiting the protein
CC       kinase activity. {ECO:0000250|UniProtKB:Q96EL1}.
CC   -!- SUBUNIT: Interacts with PAK4. {ECO:0000250|UniProtKB:Q9NTI7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NTI7}.
CC   -!- DOMAIN: The Inka box (also named iBox or inca box) binds and inhibits
CC       PAK4 by binding a substrate-like manner.
CC       {ECO:0000250|UniProtKB:Q96EL1}.
CC   -!- SIMILARITY: Belongs to the INKA family. {ECO:0000305}.
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DR   EMBL; BC149110; AAI49111.1; -; mRNA.
DR   RefSeq; NP_001094731.1; NM_001101261.1.
DR   RefSeq; XP_005204245.1; XM_005204188.3.
DR   AlphaFoldDB; A6QP24; -.
DR   SMR; A6QP24; -.
DR   STRING; 9913.ENSBTAP00000030567; -.
DR   PaxDb; A6QP24; -.
DR   PRIDE; A6QP24; -.
DR   Ensembl; ENSBTAT00000030590; ENSBTAP00000030567; ENSBTAG00000022580.
DR   GeneID; 616754; -.
DR   KEGG; bta:616754; -.
DR   CTD; 55924; -.
DR   VEuPathDB; HostDB:ENSBTAG00000022580; -.
DR   VGNC; VGNC:50127; INKA2.
DR   eggNOG; ENOG502RZNT; Eukaryota.
DR   GeneTree; ENSGT00530000063849; -.
DR   HOGENOM; CLU_082435_0_0_1; -.
DR   InParanoid; A6QP24; -.
DR   OMA; DTIDYTQ; -.
DR   OrthoDB; 794088at2759; -.
DR   TreeFam; TF332839; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000022580; Expressed in Ammon's horn and 100 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; ISS:UniProtKB.
DR   InterPro; IPR029267; FAM212.
DR   InterPro; IPR039201; Inka.
DR   PANTHER; PTHR28615; PTHR28615; 1.
DR   Pfam; PF15342; FAM212; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..294
FT                   /note="PAK4-inhibitor INKA2"
FT                   /id="PRO_0000304993"
FT   REGION          50..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..177
FT                   /note="Inka box"
FT                   /evidence="ECO:0000250|UniProtKB:Q96EL1"
FT   REGION          170..198
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          223..290
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..102
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..195
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   294 AA;  31869 MW;  456C3E572DC9101D CRC64;
     MDCYLRRLKQ ELMSMKEVGD GLQDQMNCMM GALQELKLLQ VQTALEQLEI SGGGPAPGSP
     ESPWTQLEPP QWEGSRGPVR PGACSPSNQA SLGSTSSGKF PSHRSVCGRE LATPPRTPLP
     EPQPSAQQGP ELAEPDDWTS TLMSRGRNRQ PLVLGDNVFA DLVGNWLDLP ELEKGGEKGE
     TGEAGEPKGG RGQPRELGRR FALTANIFRK FLRSVRPDRD RLLKEKPGWV TPTASEPRAG
     RSQKVKKRSH SKGSGHCPFP GASEPRRGEN ASTGCPKALE SSPSGFDINT AVWV