INLA_LISM4
ID INLA_LISM4 Reviewed; 800 AA.
AC G2K3G6; P25146; Q45GD5; Q45GD6; Q48748; Q48749; Q48750; Q48752; Q9EXG2;
DT 05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Internalin A;
DE Flags: Precursor;
GN Name=inlA; OrderedLocusNames=LMRG_00126;
OS Listeria monocytogenes serotype 1/2a (strain 10403S).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=393133;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=10403S;
RA Jiang L., Xu J., Chen N., Chen X., Fang W.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=10403S;
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Borowsky M., Borodovsky M., Young S.K., Zeng Q., Koehrsen M.,
RA Fitzgerald M., Wiedmann M., Swaminathan B., Lauer P., Portnoy D.,
RA Cossart P., Buchrieser C., Higgins D., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Borenstein D., Brown A., Chapman S.B., Chen Z.,
RA Dunbar C.D., Engels R., Freedman E., Gearin G., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E., Heiman D., Howarth C., Jen D., Larson L.,
RA Lui A., MacDonald J., Mehta T., Montmayeur A., Neiman D., Park D.,
RA Pearson M., Priest M., Richards J., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Listeria monocytogenes strain 10403S.";
RL Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates the entry of Listeria monocytogenes into cells.
CC Binds to host receptor cadherin-1 (E-cadherin, CDH1).
CC {ECO:0000250|UniProtKB:P0DJM0}.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
CC ProRule:PRU00477}.
CC -!- SIMILARITY: Belongs to the internalin family. {ECO:0000305}.
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DR EMBL; DQ132795; AAZ53236.1; -; Genomic_DNA.
DR EMBL; CP002002; AEO05444.1; -; Genomic_DNA.
DR RefSeq; WP_014600515.1; NC_017544.1.
DR AlphaFoldDB; G2K3G6; -.
DR SMR; G2K3G6; -.
DR EnsemblBacteria; AEO05444; AEO05444; LMRG_00126.
DR KEGG; lmt:LMRG_00126; -.
DR HOGENOM; CLU_019447_3_0_9; -.
DR OMA; FGSGVWI; -.
DR Proteomes; UP000001288; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.1220; -; 1.
DR Gene3D; 2.60.40.4270; -; 3.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR014755; Cu-Rt/internalin_Ig-like.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR024634; Internalin_N.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR013378; Listeria/Bacterioides_rpt.
DR InterPro; IPR042229; Listeria/Bacterioides_rpt_sf.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR012569; LRR-contain_adjacent_dom.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF09479; Flg_new; 3.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF12354; Internalin_N; 1.
DR Pfam; PF12799; LRR_4; 4.
DR Pfam; PF08191; LRR_adjacent; 1.
DR SMART; SM00369; LRR_TYP; 11.
DR SUPFAM; SSF81296; SSF81296; 1.
DR TIGRFAMs; TIGR02543; List_Bact_rpt; 3.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
DR PROSITE; PS51450; LRR; 15.
PE 3: Inferred from homology;
KW Cell wall; Leucine-rich repeat; Peptidoglycan-anchor; Repeat; Secreted;
KW Signal.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..770
FT /note="Internalin A"
FT /id="PRO_0000418519"
FT PROPEP 771..800
FT /note="Removed by sortase A"
FT /evidence="ECO:0000250|UniProtKB:P0DJM0,
FT ECO:0000255|PROSITE-ProRule:PRU00477"
FT /id="PRO_0000418520"
FT DOMAIN 36..76
FT /note="LRRNT"
FT REPEAT 77..98
FT /note="LRR 1"
FT REPEAT 99..120
FT /note="LRR 2"
FT REPEAT 121..142
FT /note="LRR 3"
FT REPEAT 143..164
FT /note="LRR 4"
FT REPEAT 165..186
FT /note="LRR 5"
FT REPEAT 187..207
FT /note="LRR 6"
FT REPEAT 208..229
FT /note="LRR 7"
FT REPEAT 230..251
FT /note="LRR 8"
FT REPEAT 252..273
FT /note="LRR 9"
FT REPEAT 274..295
FT /note="LRR 10"
FT REPEAT 296..317
FT /note="LRR 11"
FT REPEAT 318..339
FT /note="LRR 12"
FT REPEAT 340..361
FT /note="LRR 13"
FT REPEAT 362..383
FT /note="LRR 14"
FT REPEAT 384..405
FT /note="LRR 15"
FT DOMAIN 416..505
FT /note="LRRCT"
FT REPEAT 518..587
FT /note="B-1"
FT REPEAT 588..657
FT /note="B-2"
FT REPEAT 658..706
FT /note="B-3"
FT REGION 518..706
FT /note="3 X approximate tandem repeats, type B"
FT REGION 705..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 767..771
FT /note="LPXTG sorting signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT MOD_RES 770
FT /note="Pentaglycyl murein peptidoglycan amidated threonine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT CONFLICT 791
FT /note="A -> V (in Ref. 1; AAZ53236)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 800 AA; 86487 MW; 6D2D4C61505B8EEE CRC64;
MRKKRYVWLK SILVAILVFG SGVWINTSNG TNAQAATITQ DTPINQIFTD AALAEKMKTV
LGKTNVTDTV SQTDLDQVTT LQADRLGIKS IDGLEYLNNL TQINFSNNQL TDITPLKDLT
KLVDILMNNN QIADITPLAN LTNLTGLTLF NNQITDIDPL KNLTNLNRLE LSSNTISDIS
ALSGLTNLQQ LSFGNQVTDL KPLANLTTLE RLDISSNKVS DISVLAKLTN LESLIATNNQ
ISDITPLGIL TNLDELSLNG NQLKDIGTLA SLTNLTDLDL ANNQISNLAP LSGLTKLTEL
KLGANQISNI SPLAGLTALT NLELNENQLE DISPISNLKN LTYLTLYFNN ISDISPVSSL
TKLQRLFFYN NKVSDVSSLA NLTNINWLSA GHNQISDLTP LANLTRITQL GLNDQAWTNA
PVNYKANVSI PNTVKNVTGA LIAPATISDG GSYAEPDITW NLPSYTNEVS YTFSQPVTIG
KGTTTFSGTV TQPLKAIFNA KFHVDGKETT KEVEAGNLLT EPAKPVKEGH TFVGWFDAQT
GGTKWNFSTD KMPTNDINLY AQFSINSYTA TFENDGVTTS QTVDYQGLLQ EPTPPTKEGY
TFKGWYDAKT GGDKWDFATS KMPAKNITLY AQYSANSYTA TFDVDGKSTT QAVDYQGLLK
EPKAPTKAGY TFKGWYDEKT DGKKWDFATD KMPANDITLY AQFTKNPVAP PTTGGNTPPT
TNNGGNTTPP SANIPGSDTS NTSTGNSAST TSTMNAYDPY NSKEASLPTT GDSDNALYLL
LGLLAVGTAM ALTKKARASK
