INLA_LISMF
ID INLA_LISMF Reviewed; 800 AA.
AC Q723K6;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Internalin A;
DE Flags: Precursor;
GN Name=inlA; OrderedLocusNames=LMOf2365_0471;
OS Listeria monocytogenes serotype 4b (strain F2365).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=265669;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F2365;
RX PubMed=15115801; DOI=10.1093/nar/gkh562;
RA Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F.,
RA Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D.,
RA White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M.,
RA Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R., Haft D.H.,
RA Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A.,
RA Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O.,
RA Luchansky J.B., Fraser C.M.;
RT "Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne
RT pathogen Listeria monocytogenes reveal new insights into the core genome
RT components of this species.";
RL Nucleic Acids Res. 32:2386-2395(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 73-418.
RX PubMed=9541569; DOI=10.1007/s002849900315;
RA Vines A., Swaminathan B.;
RT "Identification and characterization of nucleotide sequence differences in
RT three virulence-associated genes of Listeria monocytogenes strains
RT representing clinically important serotypes.";
RL Curr. Microbiol. 36:309-318(1998).
CC -!- FUNCTION: Mediates the entry of Listeria monocytogenes into cells.
CC Binds to host receptor cadherin-1 (E-cadherin, CDH1).
CC {ECO:0000250|UniProtKB:P0DJM0}.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
CC ProRule:PRU00477}.
CC -!- SIMILARITY: Belongs to the internalin family. {ECO:0000305}.
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DR EMBL; AE017262; AAT03255.1; -; Genomic_DNA.
DR EMBL; U25445; AAA69527.1; -; Genomic_DNA.
DR RefSeq; WP_003734628.1; NC_002973.6.
DR AlphaFoldDB; Q723K6; -.
DR SMR; Q723K6; -.
DR KEGG; lmf:LMOf2365_0471; -.
DR HOGENOM; CLU_019447_3_0_9; -.
DR OMA; FGSGVWI; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.1220; -; 1.
DR Gene3D; 2.60.40.4270; -; 3.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR014755; Cu-Rt/internalin_Ig-like.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR024634; Internalin_N.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR013378; Listeria/Bacterioides_rpt.
DR InterPro; IPR042229; Listeria/Bacterioides_rpt_sf.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR012569; LRR-contain_adjacent_dom.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF09479; Flg_new; 3.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF12354; Internalin_N; 1.
DR Pfam; PF12799; LRR_4; 4.
DR Pfam; PF08191; LRR_adjacent; 1.
DR SMART; SM00369; LRR_TYP; 11.
DR SUPFAM; SSF81296; SSF81296; 1.
DR TIGRFAMs; TIGR02543; List_Bact_rpt; 3.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
DR PROSITE; PS51450; LRR; 15.
PE 3: Inferred from homology;
KW Cell wall; Leucine-rich repeat; Peptidoglycan-anchor; Repeat; Secreted;
KW Signal.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..770
FT /note="Internalin A"
FT /id="PRO_0000005607"
FT PROPEP 771..800
FT /note="Removed by sortase A"
FT /evidence="ECO:0000250|UniProtKB:P0DJM0,
FT ECO:0000255|PROSITE-ProRule:PRU00477"
FT /id="PRO_0000005608"
FT DOMAIN 36..76
FT /note="LRRNT"
FT REPEAT 77..98
FT /note="LRR 1"
FT REPEAT 99..120
FT /note="LRR 2"
FT REPEAT 121..142
FT /note="LRR 3"
FT REPEAT 143..164
FT /note="LRR 4"
FT REPEAT 165..186
FT /note="LRR 5"
FT REPEAT 187..207
FT /note="LRR 6"
FT REPEAT 208..229
FT /note="LRR 7"
FT REPEAT 230..251
FT /note="LRR 8"
FT REPEAT 252..273
FT /note="LRR 9"
FT REPEAT 274..295
FT /note="LRR 10"
FT REPEAT 296..317
FT /note="LRR 11"
FT REPEAT 318..339
FT /note="LRR 12"
FT REPEAT 340..361
FT /note="LRR 13"
FT REPEAT 362..383
FT /note="LRR 14"
FT REPEAT 384..405
FT /note="LRR 15"
FT DOMAIN 416..505
FT /note="LRRCT"
FT REPEAT 518..587
FT /note="B-1"
FT REPEAT 588..657
FT /note="B-2"
FT REPEAT 658..706
FT /note="B-3"
FT REGION 518..706
FT /note="3 X approximate tandem repeats, type B"
FT REGION 705..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 767..771
FT /note="LPXTG sorting signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT MOD_RES 770
FT /note="Pentaglycyl murein peptidoglycan amidated threonine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
SQ SEQUENCE 800 AA; 86631 MW; DE837CC0045993E7 CRC64;
MRRKRYVWLK SILVAILVFG SGVWINTSNG TNAQAATITQ DTPINQIFTD TALAEKMKTV
LGKTNVTDTV SQTDLDQVTT LQADRLGIKS IDGLEYLNNL TQINFSNNQL TDITPLKDLT
KLVDILMNNN QIADITPLAN LSNLTGLTLF NNQITDIDPL KNLTNLNRLE LSSNTISDIS
ALSGLTSLQQ LSFGNQVTDL KPLANLTTLE RLDISSNKVS DISVLAKLTN LESLIATNNQ
ISDITPLGIL TNLDELSLNG NQLKDIGTLA SLTNLTDLDL ANNQISNLAP LSGLTKLTEL
KLGANQISNI SPLAGLTALT NLELNENQLE DISPISNLKN LTYLTLYFNN ISDISPVSSL
TKLQRLFFYN NKVSDVSSLA NLTNINWLSA GHNQISDLTP LANLTRITQL GLNDQEWTNP
PVNYKVNVSI PNTVKNVTGA LIAPATISDG GSYAEPDITW NLPSYTNEVS YTFNQSVTIG
KGTTTFSGTV TQPLKAIFNA KFHVDGKETT KEVEAGNLLT EPAKPVKEGY TFVGWFDAQT
GGTKWNFSTD KMPTNDIDLY AQFSINSYTA TFDNDGVTTS QTVDYQGLLQ EPTAPTKEGY
TFKGWYDAKT GGDKWDFATS KMPAKNITLY AQYSANSYTA TFDVDGKTTT QAVDYQGLLK
EPKTPTKAGY TFKGWYDEKT DGKKWDFATD KMPANDITLY AQFTKNPVAP PTTGGNTPPT
TNNGGNTTPP SANIPGSNTS NTSTGNSAST TSTMNAYDPY NSKEASLPTT GDSDNALYLL
IGLLAVGTAV ALTKKARASK
