ID   INLI_LISMF              Reviewed;        1775 AA.
AC   Q723X5;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Internalin I;
DE   Flags: Precursor;
GN   Name=inlI; OrderedLocusNames=LMOf2365_0350;
OS   Listeria monocytogenes serotype 4b (strain F2365).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=265669;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F2365;
RX   PubMed=15115801; DOI=10.1093/nar/gkh562;
RA   Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F.,
RA   Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D.,
RA   White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M.,
RA   Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R., Haft D.H.,
RA   Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A.,
RA   Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O.,
RA   Luchansky J.B., Fraser C.M.;
RT   "Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne
RT   pathogen Listeria monocytogenes reveal new insights into the core genome
RT   components of this species.";
RL   Nucleic Acids Res. 32:2386-2395(2004).
CC   -!- FUNCTION: A role in virulence could not be demonstrated.
CC       {ECO:0000250|UniProtKB:Q8YA32}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
CC       ProRule:PRU00477}.
CC   -!- SIMILARITY: Belongs to the internalin family. {ECO:0000305}.
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DR   EMBL; AE017262; AAT03136.1; -; Genomic_DNA.
DR   RefSeq; WP_003724263.1; NC_002973.6.
DR   AlphaFoldDB; Q723X5; -.
DR   SMR; Q723X5; -.
DR   KEGG; lmf:LMOf2365_0350; -.
DR   HOGENOM; CLU_241292_0_0_9; -.
DR   OMA; SAQGCNI; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 8.
DR   Gene3D; 2.60.40.1220; -; 1.
DR   Gene3D; 3.80.10.10; -; 4.
DR   InterPro; IPR014755; Cu-Rt/internalin_Ig-like.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR044056; InlI_Ig-like.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR025875; Leu-rich_rpt_4.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR019931; LPXTG_anchor.
DR   InterPro; IPR012569; LRR-contain_adjacent_dom.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR009459; MucBP_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   Pfam; PF18981; InlK_D3; 8.
DR   Pfam; PF12799; LRR_4; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   Pfam; PF08191; LRR_adjacent; 1.
DR   Pfam; PF06458; MucBP; 3.
DR   SMART; SM00369; LRR_TYP; 11.
DR   SUPFAM; SSF49299; SSF49299; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
DR   PROSITE; PS51450; LRR; 23.
PE   3: Inferred from homology;
KW   Cell wall; Leucine-rich repeat; Peptidoglycan-anchor; Repeat; Secreted;
KW   Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..1743
FT                   /note="Internalin I"
FT                   /id="PRO_0000252673"
FT   PROPEP          1744..1775
FT                   /note="Removed by sortase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT                   /id="PRO_0000252674"
FT   REPEAT          152..176
FT                   /note="LRR 1"
FT   REPEAT          180..201
FT                   /note="LRR 2"
FT   REPEAT          202..224
FT                   /note="LRR 3"
FT   REPEAT          225..247
FT                   /note="LRR 4"
FT   REPEAT          248..269
FT                   /note="LRR 5"
FT   REPEAT          274..295
FT                   /note="LRR 6"
FT   REPEAT          296..318
FT                   /note="LRR 7"
FT   REPEAT          319..341
FT                   /note="LRR 8"
FT   REPEAT          342..364
FT                   /note="LRR 9"
FT   REPEAT          365..386
FT                   /note="LRR 10"
FT   REPEAT          387..409
FT                   /note="LRR 11"
FT   REPEAT          410..431
FT                   /note="LRR 12"
FT   REPEAT          432..453
FT                   /note="LRR 13"
FT   REPEAT          454..475
FT                   /note="LRR 14"
FT   REPEAT          476..497
FT                   /note="LRR 15"
FT   REPEAT          498..519
FT                   /note="LRR 16"
FT   REPEAT          520..541
FT                   /note="LRR 17"
FT   REPEAT          542..563
FT                   /note="LRR 18"
FT   REPEAT          564..585
FT                   /note="LRR 19"
FT   REPEAT          586..607
FT                   /note="LRR 20"
FT   REPEAT          608..629
FT                   /note="LRR 21"
FT   REPEAT          630..650
FT                   /note="LRR 22"
FT   REPEAT          654..675
FT                   /note="LRR 23"
FT   REPEAT          682..704
FT                   /note="LRR 24"
FT   REPEAT          705..726
FT                   /note="LRR 25"
FT   REPEAT          727..748
FT                   /note="LRR 26"
FT   REPEAT          749..770
FT                   /note="LRR 27"
FT   DOMAIN          782..869
FT                   /note="LRRCT"
FT   DOMAIN          1507..1566
FT                   /note="MucBP 1"
FT   DOMAIN          1572..1631
FT                   /note="MucBP 2"
FT   DOMAIN          1641..1702
FT                   /note="MucBP 3"
FT   REGION          36..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1713..1737
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           1740..1744
FT                   /note="LPXTG sorting signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT   COMPBIAS        36..53
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..87
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1743
FT                   /note="Pentaglycyl murein peptidoglycan amidated threonine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
SQ   SEQUENCE   1775 AA;  191295 MW;  2D8052CF7A4C4443 CRC64;
     MKKKFSIVII SVLLLGYLAP FDTLLVGADE TTVTEDTTVK TAETETATEA TESESGSDNE
     KAEEPKEAEA SKETTEKEEK AKTKEPASNI KTEINTDKSQ LKQTNLKAVV PAGSTYNSLF
     PDDNLAKKLA VIITGNAAAT GNESVDSAAL LAISQLDLSG ETGNDPTDIS NIEGLQYLEN
     LTSLNLSENN ISDLAPIKDL VNLVSLNLSS NRTLVNLSGV EGLVNLQELN VSANKALEDI
     SQVAALPVLK EISAQGCNIK TLELDNPAGA ILPELETFYL QENDLTDLTS LAKLPKLKNL
     YIKGNASLKS LATLKGATKL QLIDASNCTD LETLGDISGL SELEMIQLSG CSKLKEITSL
     KDLPNLVNIT ADSCAIEDLG TLNNLPKLQT LILSDNKDLT NINAITDMPQ LKTLALDGCG
     ITSIGTLDNL PKLEKLDLKE NQLTSISEIN DLPRLSYLDV SVNYLTTIGE LKKLPLLEWL
     NVSSNRLSDV STLTNFPSLN YINVSNNVIR TVGKMTELPS LKEFYAQNNN VSDISMIHDM
     PNLRKVDASN NLITNIGTFD NLPKLQNLDV HSNRITNTSV IHDLPSLETF YAQNNLITNI
     GTMDNLPELT YVDLSFNRIP SLAPIGDLPK LEILKVTDNY SYLRSLGTMD GVSKLRNLEL
     QNNYLNYTGT EGNLSALSDL TNLTELNLRD NGYISDISGL STLSRLIYLN LDSNKIKDIS
     ALSNLTTLQE LTLENNQIED ISALSDLDNL NKLALSKNKI IDISPAANMV NRGASVTASN
     QTYTLPTVLS YQSSFTIDNP VVWYDGTPLA PSSIAHSGTY KDGEITWTNM TAASSSTEFN
     FNRLKDGLTF SGTITQPYKS AVKVTANAEQ TYTIGDTISE EQFLKDVNAK SSDGAPVTSD
     FATVVDLNTF GEYEVTLTSE KDGIQGDSCK VIVKVLHGAP VISADQTINY DKHATITEKQ
     FLEDVHASTD LNTAITTNFS TAVNLNKGGD YTVALNSENE DGVKAETVYV TVTVDKDPAP
     IISAKTDITY DKFSKKTEAA FLDDIDADTN DGSIITSNFA TAVNLDKAGD YTVTLNSINS
     DGVASTPTAI IVHVEKEKIA TISANTAQQY EKYAEINETQ FLKDVHASIN ASPTTAVLES
     DFETVVKLDV PGTYTVTITA TNEDGGVSAP KEVSVIVKKL PAPEITADKE ITYPKFDEVS
     EAEFLSDIHA TINEKNVTIT SNFSADVNLN KAGDYTVTLN ATNEDGVKAT PVEVIVHVQQ
     GERPVITADA TISYDKFANI TEAKFLEDIH ATSSDGQSST VITSNFETAT NFKTAMSYTV
     TLNAVNEDGI SAEPVAVTVT INKEPAATLK ADAEVSYAKN EAVTESDFFK DVHLEGAEAP
     STAKATSNFD SVVDRSKTGD YTVTINATNE DGAVSTPIEV IVHIGAESAP VITANAEVKY
     NKHEQTDERR FLYDSDAKID EANVEIKTDF AEKVDINKVG TYTVTLTATN EDGQAANPVE
     VSVIVSDAAA EKVNVKYVDE NGAEISAAET LTGNLDDAFS IDAKSIAGYK CDATLSGVFS
     TVEQTVVFHY KAIEPGVVTI KYEDANGKAV AEDKQITGEV GDDFEAEAQT VSGYSCRAIA
     SGKITEEPQT ITFTYTTATP SKKSGEITVQ YVDESGKKLA DSKKVTGDID DSYSVEAKAI
     DGYSVVGDDS AKGVFTEKSQ TVTFKYKKNT QVSKDEPKVK GKTNQPPSAD TKLKVDNNTL
     PATGDTENMA LAVLIGFNML LVASIFLFRK PKTNQ