ID   INO1A_XENLA             Reviewed;         563 AA.
AC   Q7ZXY0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Inositol-3-phosphate synthase 1-A;
DE            Short=IPS 1-A;
DE            EC=5.5.1.4;
DE   AltName: Full=Myo-inositol 1-phosphate synthase A;
DE            Short=MI-1-P synthase A;
DE            Short=MIP synthase A;
GN   Name=isyna1-a; Synonyms=ino1-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key enzyme in myo-inositol biosynthesis pathway that
CC       catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-
CC       phosphate in a NAD-dependent manner. Rate-limiting enzyme in the
CC       synthesis of all inositol-containing compounds (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC         Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC         EC=5.5.1.4;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
CC   -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC       from D-glucose 6-phosphate: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC       {ECO:0000305}.
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DR   EMBL; BC044073; AAH44073.1; -; mRNA.
DR   RefSeq; NP_001079540.1; NM_001086071.1.
DR   AlphaFoldDB; Q7ZXY0; -.
DR   SMR; Q7ZXY0; -.
DR   DNASU; 379227; -.
DR   GeneID; 379227; -.
DR   KEGG; xla:379227; -.
DR   CTD; 379227; -.
DR   Xenbase; XB-GENE-969423; isyna1.S.
DR   UniPathway; UPA00823; UER00787.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 379227; Expressed in ovary and 20 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004512; F:inositol-3-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR   InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR11510; PTHR11510; 1.
DR   Pfam; PF01658; Inos-1-P_synth; 1.
DR   Pfam; PF07994; NAD_binding_5; 1.
DR   PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Inositol biosynthesis; Isomerase; Lipid biosynthesis;
KW   Lipid metabolism; NAD; Phospholipid biosynthesis; Phospholipid metabolism;
KW   Reference proteome.
FT   CHAIN           1..563
FT                   /note="Inositol-3-phosphate synthase 1-A"
FT                   /id="PRO_0000324632"
SQ   SEQUENCE   563 AA;  62355 MW;  0848574C76FA4C36 CRC64;
     MAEKFKVESP HVRYLKDVIE ADYNYDTTQV YEEKGVTKVK PCSTKFTFHT ERKVPKLGVM
     LVGWGGNNGT TVTAAVLANR LGLSWMTKTG KKVANYYGSL FQSSTACLGS GPAGDVFVPF
     RDLLPMVHPN DIVFDGWDIS SLNLADAMFR AEVLDWQIQE QLRPYMEKMK PRPSIYIPDF
     IAANQEDRAD HTIHGTKAEQ VQKIREDIQD FKRTSDVDKV IVLWTANTER FCDIIPGVND
     TADNLLKAIE NGLEVSPSTM FAVASILEGC AYINGSPQNT FVPGAIELAV QNNVFIGGDD
     FKSGQTKIKS VLMDFLVSAG LKPVSIVSYN HLGNNDGKNL SAPQQFRSKE ISKSNVVDDM
     VQSNPILYGP NEKPDHCVVI KYVPYVGDSK RAMDEYTSEI MMGGANTIVL HNTCEDSLLA
     SPIILDLVLL TELCQRITFR TETDQEFQTF HSVLSILSFL CKAPLVPAGT PVINAFFRQR
     NCIENILRAC LGLSPQNHMM LEHKMQRSFV SLKRPSTVCN PQPISSKKGN NANGFHLPGI
     SKGLSQSNGL GKNVINSDIE IEN