ID   INO1_BRANA              Reviewed;         510 AA.
AC   Q96348;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Inositol-3-phosphate synthase;
DE            Short=MIP synthase;
DE            EC=5.5.1.4;
DE   AltName: Full=Myo-inositol 1-phosphate synthase;
DE            Short=IPS;
DE            Short=MI-1-P synthase;
OS   Brassica napus (Rape).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Brassica.
OX   NCBI_TaxID=3708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hussain A., Bourgeois J., Polvi S., Tsang E., Keller W.A., Georges F.;
RT   "Cloning of a full length cDNA encoding myo-inositol 1-phosphate synthase
RT   from Brassica napus.";
RL   Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC         Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC         EC=5.5.1.4;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
CC   -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC       from D-glucose 6-phosphate: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC       {ECO:0000305}.
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DR   EMBL; U66307; AAB06756.2; -; mRNA.
DR   PIR; T08436; T08436.
DR   AlphaFoldDB; Q96348; -.
DR   SMR; Q96348; -.
DR   UniPathway; UPA00823; UER00787.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004512; F:inositol-3-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR   InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR11510; PTHR11510; 1.
DR   Pfam; PF01658; Inos-1-P_synth; 1.
DR   Pfam; PF07994; NAD_binding_5; 1.
DR   PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Inositol biosynthesis; Isomerase; Lipid biosynthesis;
KW   Lipid metabolism; NAD; Phospholipid biosynthesis; Phospholipid metabolism.
FT   CHAIN           1..510
FT                   /note="Inositol-3-phosphate synthase"
FT                   /id="PRO_0000195189"
SQ   SEQUENCE   510 AA;  56378 MW;  A40EB6558D880739 CRC64;
     MFIESFKVES PNVKYTENEI HSVYDYETTE VVHENVNGAY QWIVKPKVVK YDFKTDTRVP
     KLGVMLVGWG GNNGSTLTAG VIANKEGISW ATKDKVQQAN YFGSLTQASS IRVGSFNGEE
     MYAPFKSLVP MVNPDDVVFG GWDISDMNLA DAMGRAKVLD IDLQKQLRPY MENIVPLPGI
     YDPDFIAANQ GSRANNVIKG TKKEQVDQII KDMREFKEKN KVDKVVVLWT ANTERYSNVI
     VGLNDTMENL MNSVDRDESE ISPSTLYAIA CVLEGIPFIN GSPQNTFVPG LIDLAIKNNV
     LIGGDDFKSG QTKMKSVLVD FLVGAGIKPT SIVSYNHLGN NDGMNLSAPQ TFRSKEISKS
     NVVDDMVASN GILFEPGEHP DHVVVIKYVP YVADSKRAMD EYTSEIFMGG KNTIVMHNTC
     EDSLLAAPII LDLVLLAEIS TRIQFKSEKE GKFHSFHPVA TKLSYLTKAP LVPPGTPVVN
     ALSKQRAMLE NILRACVGLA PENNMILEYK