ID   INO1_CANAL              Reviewed;         520 AA.
AC   P42800; A0A1D8PU49; Q5ACQ8;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=Inositol-3-phosphate synthase;
DE            Short=MIP synthase;
DE            EC=5.5.1.4;
DE   AltName: Full=Myo-inositol 1-phosphate synthase;
DE            Short=IPS;
DE            Short=MI-1-P synthase;
GN   Name=INO1; OrderedLocusNames=CAALFM_CR10100CA; ORFNames=CaO19.7585;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594;
RX   PubMed=7975896; DOI=10.1002/yea.320100609;
RA   Klig L.S., Zobel P.A., Devry C.G., Losberger C.;
RT   "Comparison of INO1 gene sequences and products in Candida albicans and
RT   Saccharomyces cerevisiae.";
RL   Yeast 10:789-800(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC         Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC         EC=5.5.1.4;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC   -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC       from D-glucose 6-phosphate: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC       {ECO:0000305}.
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DR   EMBL; L22737; AAA62849.1; -; Genomic_DNA.
DR   EMBL; CP017630; AOW31662.1; -; Genomic_DNA.
DR   PIR; S45452; S45452.
DR   RefSeq; XP_719347.1; XM_714254.1.
DR   AlphaFoldDB; P42800; -.
DR   SMR; P42800; -.
DR   STRING; 237561.P42800; -.
DR   COMPLUYEAST-2DPAGE; P42800; -.
DR   GeneID; 3638966; -.
DR   KEGG; cal:CAALFM_CR10100CA; -.
DR   CGD; CAL0000189325; INO1.
DR   VEuPathDB; FungiDB:CR_10100C_A; -.
DR   eggNOG; KOG0693; Eukaryota.
DR   HOGENOM; CLU_021486_2_0_1; -.
DR   InParanoid; P42800; -.
DR   OMA; EHDLFIQ; -.
DR   OrthoDB; 451916at2759; -.
DR   UniPathway; UPA00823; UER00787.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0009986; C:cell surface; IDA:CGD.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030446; C:hyphal cell wall; IDA:CGD.
DR   GO; GO:0004512; F:inositol-3-phosphate synthase activity; IGI:CGD.
DR   GO; GO:0006021; P:inositol biosynthetic process; IMP:CGD.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR   InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR11510; PTHR11510; 1.
DR   Pfam; PF01658; Inos-1-P_synth; 1.
DR   Pfam; PF07994; NAD_binding_5; 1.
DR   PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Inositol biosynthesis; Isomerase; Lipid biosynthesis;
KW   Lipid metabolism; NAD; Phospholipid biosynthesis; Phospholipid metabolism;
KW   Reference proteome.
FT   CHAIN           1..520
FT                   /note="Inositol-3-phosphate synthase"
FT                   /id="PRO_0000195183"
SQ   SEQUENCE   520 AA;  57779 MW;  AC705DA4C0401B07 CRC64;
     MSTPIEFKSS NSVTKDDHLY TKFTYENSVV EKDANGKFIV TPTASDYEFK VDLKVPKVGL
     LLVGIGGNNG TTLLGATLAN KHNISFENKE GVVKPNYYGS VTQASTVKIG VDKETGEDVY
     VPFNSIVPMV NPNDLVVDGW DISGLPLDQA MKRAKVLDVT LQKQLYPYLE NKKPLESIYY
     PDFIALNQSE RANNVFNQVN GEVKTDNKWA DVEKIRKDIR DFKAKNELDK VIILWTANTE
     RYADVLPNVN DTADNLIKSI KESHEEIAPS TVFAVASILE KVPYINGSPQ NTFVPGVIEL
     AEKYDSFIGG DDFKSGQTKI KSVLAQFLVD AGIKPLSIAS YNHLGNNDGY NLSSPKQFRS
     KEISKQSVVD DIIESNELLY NKESGDKVDH CIVIKYLPAV GDSKVAMDEY YSELMLGGHN
     KISIHNVCED SLLATPLIID LVVATEFATR VQVKGPGKSD YDELYPVASL LSYWLKAPLA
     RPGFKPINGL NKQRQQLVNL LSVLVGLPID NELRFERILK