ID   INO1_CITPA              Reviewed;         507 AA.
AC   P42802;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Inositol-3-phosphate synthase;
DE            Short=MIP synthase;
DE            EC=5.5.1.4;
DE   AltName: Full=Myo-inositol 1-phosphate synthase;
DE            Short=IPS;
DE            Short=MI-1-P synthase;
OS   Citrus paradisi (Grapefruit).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Sapindales; Rutaceae; Aurantioideae; Citrus.
OX   NCBI_TaxID=37656;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Leaf;
RX   PubMed=7846170; DOI=10.1104/pp.106.4.1689;
RA   Abu-Abied M., Holland D.;
RT   "The gene c-ino1 from Citrus paradisi is highly homologous to tur1 and ino1
RT   from yeast and Spirodela encoding for myo-inositol phosphate synthase.";
RL   Plant Physiol. 106:1689-1689(1994).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC         Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC         EC=5.5.1.4;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC   -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC       from D-glucose 6-phosphate: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC       {ECO:0000305}.
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DR   EMBL; Z32632; CAA83565.1; -; Genomic_DNA.
DR   PIR; S52648; S52648.
DR   AlphaFoldDB; P42802; -.
DR   SMR; P42802; -.
DR   UniPathway; UPA00823; UER00787.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004512; F:inositol-3-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR   InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR11510; PTHR11510; 1.
DR   Pfam; PF01658; Inos-1-P_synth; 1.
DR   Pfam; PF07994; NAD_binding_5; 1.
DR   PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Inositol biosynthesis; Isomerase; Lipid biosynthesis;
KW   Lipid metabolism; NAD; Phospholipid biosynthesis; Phospholipid metabolism.
FT   CHAIN           1..507
FT                   /note="Inositol-3-phosphate synthase"
FT                   /id="PRO_0000195190"
SQ   SEQUENCE   507 AA;  56335 MW;  45D78928991BFDF8 CRC64;
     MFIENFKVES PNVKYTDHEI HSVYDYETTE LVHENRNGTY QWIVKPKTVK YEFKTDVHVP
     KLGVMLVGWG GNNGSTLTGG VIANREGICW ATKDTVQQAN YFGSLTQASA IRVGSYNGEE
     IYAPFKSILP MVNPDDIVFG GWDISDMNLA DAMARARVFD IDLQKQLRPY MESMVPLPGI
     YDPDFIAANQ GSRANNVIKG TKKEQMLQII KDIREFKEKN KVDRVVVLWT ANTERYSNVI
     VGLNDTVESL LASLDKNEAE ISPSTLYAIA CVLENIPFIN GSPQNTFVPG LIDLAIRRNC
     LIGGDDFKSG QTKMKSVLVD FLVGAGIKPT SIVSYNHLGN NDGMNLSAPQ TFRSKEISKS
     NVVDDMVSSN VFFMGLVNTR PRWIKYVPYV AIERAMDEYT SEIFMGGKST IVLHNTCEDS
     LLAAPIILDL VLLAELSTRI QLKAEGEGKF HSFHPVATIL SYLTKAPLVP PGTPVVNALS
     KQRAMLENIL RACVGLAPEN NMILEYK