ID   INO1_DICDI              Reviewed;         511 AA.
AC   Q54N49;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Inositol-3-phosphate synthase;
DE            EC=5.5.1.4;
DE   AltName: Full=Myo-inositol 1-phosphate synthase;
DE            Short=IPS;
DE            Short=MI-1-P synthase;
DE            Short=MIP synthase;
GN   Name=ino1; ORFNames=DDB_G0285505;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Key enzyme in myo-inositol biosynthesis pathway that
CC       catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-
CC       phosphate in a NAD-dependent manner. Rate-limiting enzyme in the
CC       synthesis of all inositol-containing compounds (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC         Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC         EC=5.5.1.4;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
CC   -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC       from D-glucose 6-phosphate: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000079; EAL64590.1; -; Genomic_DNA.
DR   RefSeq; XP_638094.1; XM_633002.1.
DR   AlphaFoldDB; Q54N49; -.
DR   SMR; Q54N49; -.
DR   STRING; 44689.DDB0231710; -.
DR   PaxDb; Q54N49; -.
DR   EnsemblProtists; EAL64590; EAL64590; DDB_G0285505.
DR   GeneID; 8625142; -.
DR   KEGG; ddi:DDB_G0285505; -.
DR   dictyBase; DDB_G0285505; ino1.
DR   eggNOG; KOG0693; Eukaryota.
DR   HOGENOM; CLU_021486_2_0_1; -.
DR   InParanoid; Q54N49; -.
DR   OMA; EHDLFIQ; -.
DR   PhylomeDB; Q54N49; -.
DR   BioCyc; MetaCyc:MON-15198; -.
DR   BRENDA; 5.5.1.4; 1939.
DR   Reactome; R-DDI-1855183; Synthesis of IP2, IP, and Ins in the cytosol.
DR   UniPathway; UPA00823; UER00787.
DR   PRO; PR:Q54N49; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IDA:dictyBase.
DR   GO; GO:0004512; F:inositol-3-phosphate synthase activity; IMP:dictyBase.
DR   GO; GO:0006914; P:autophagy; IMP:dictyBase.
DR   GO; GO:0031589; P:cell-substrate adhesion; IMP:dictyBase.
DR   GO; GO:0006021; P:inositol biosynthetic process; IMP:dictyBase.
DR   GO; GO:0000281; P:mitotic cytokinesis; IMP:dictyBase.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:1903725; P:regulation of phospholipid metabolic process; IMP:dictyBase.
DR   InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR   InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR11510; PTHR11510; 1.
DR   Pfam; PF01658; Inos-1-P_synth; 1.
DR   Pfam; PF07994; NAD_binding_5; 1.
DR   PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Inositol biosynthesis; Isomerase; Lipid biosynthesis;
KW   Lipid metabolism; NAD; Phospholipid biosynthesis; Phospholipid metabolism;
KW   Reference proteome.
FT   CHAIN           1..511
FT                   /note="Inositol-3-phosphate synthase"
FT                   /id="PRO_0000331194"
SQ   SEQUENCE   511 AA;  56847 MW;  70D018C566B1C5FF CRC64;
     MSAQMFESFK VNSPNVKYTD EHIISDYTYQ TTKVQNVNGE LIVEPVDQKY IFKTERKVPR
     MGVMIVGLCG NNGTTVVGGV IANREGLCWN TKQGLQTPNY FGSVVMSSTI RMGMDENGCD
     AYIPLKNLIP MVHPNDIVFG GWDINNANLA DAMQRAQVFD YDLQVQLIPH MKNITPLPSI
     YFPDFIAANQ KDRANNVLTG TKKEQMEQIR KDIRDFKESN KLDTVVVMWS ANTERFSSLV
     PGVNDTIENL MAAIDRSEEE ISPSTLFAVA SILENTTYIN GSPQNTFVPA VVDLAIQHNV
     SIGGDDFKTG QTKIKSVLTD YLVSAGIKPV SIVSYNHLGN NDGKNLSAPQ QFRSKEITKS
     NVVDDMIASN NILYKQGEHP DHVIVIKYVP YVGDSKRAMD EYTSQIFMGG HNTIVLHNTC
     EDSLLAAPII LDLVILAEVT SRITMKKQDD DQFATFHPVL SLLSYLLKAP IVPKHATVVN
     ALFKQRACIE NIFKACVGIA PDNNMLLEQR L