ID   INO1_MESCR              Reviewed;         512 AA.
AC   Q40271;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Inositol-3-phosphate synthase;
DE            Short=MIP synthase;
DE            EC=5.5.1.4;
DE   AltName: Full=Myo-inositol 1-phosphate synthase;
DE            Short=IPS;
DE            Short=MI-1-P synthase;
OS   Mesembryanthemum crystallinum (Common ice plant) (Cryophytum crystallinum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   Caryophyllales; Aizoaceae; Mesembryanthemum;
OC   Mesembryanthemum subgen. Cryophytum.
OX   NCBI_TaxID=3544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8624516; DOI=10.1046/j.1365-313x.1996.09040537.x;
RA   Ishitani M., Majumder A.L., Bornhouser A., Michalowski C.B., Jensen R.G.,
RA   Bohnert H.J.;
RT   "Coordinate transcriptional induction of myo-inositol metabolism during
RT   environmental stress.";
RL   Plant J. 9:537-548(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate;
CC         Xref=Rhea:RHEA:10716, ChEBI:CHEBI:58401, ChEBI:CHEBI:61548;
CC         EC=5.5.1.4;
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000250};
CC   -!- PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol
CC       from D-glucose 6-phosphate: step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the myo-inositol 1-phosphate synthase family.
CC       {ECO:0000305}.
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DR   EMBL; U32511; AAB03687.1; -; mRNA.
DR   PIR; T12438; T12438.
DR   AlphaFoldDB; Q40271; -.
DR   SMR; Q40271; -.
DR   UniPathway; UPA00823; UER00787.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004512; F:inositol-3-phosphate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006021; P:inositol biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR002587; Myo-inos-1-P_Synthase.
DR   InterPro; IPR013021; Myo-inos-1-P_Synthase_GAPDH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR11510; PTHR11510; 1.
DR   Pfam; PF01658; Inos-1-P_synth; 1.
DR   Pfam; PF07994; NAD_binding_5; 1.
DR   PIRSF; PIRSF015578; Myoinos-ppht_syn; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Inositol biosynthesis; Isomerase; Lipid biosynthesis;
KW   Lipid metabolism; NAD; Phospholipid biosynthesis; Phospholipid metabolism.
FT   CHAIN           1..512
FT                   /note="Inositol-3-phosphate synthase"
FT                   /id="PRO_0000195193"
SQ   SEQUENCE   512 AA;  56759 MW;  DF4B7109F47E8516 CRC64;
     MFIESFKVES PNVKYTENEI ESVYNYDTTE LVHENRKDAG GYQWIVKPKT VQYHFKTDTR
     VPKLGVMLVG WGGNNGSTLT GGVIANREGI SWATKDKIQQ ANYFGSLTQA SSIRVGSFNG
     EEIYAPFKSL LPMVNPDDVV FGGWDISDMN LADAMTRARV FDIDLQKQLR PYMEHMVPLP
     GIYDPDFIAA NQGSRANNVI KGTKKEQVER VIKDIREFKE KNKVDKVVVL WTGNTERYSN
     VVVGLNDTME NLLASLEKNE SEISPSTSYA LACIEENIPF INGSPQNTFV PGLIDLAIKK
     NSLIGGDDFK SGQTKMKSVL VDFLVGAGIK PTSIVSYNHL GNNDGMNLSA PQTFRSKEIS
     KSNVVDDMVA SNGILYEPGE HPDHVVVIKY VPYVGDSKRA MDEYTSEIFM GGTNTIVMHN
     TCEDSLLAAP IILDLVLLAE LSTRIQLKAE EEDKFHSFHP VATILSYLTK APLVPPGTPV
     VNALSKQRAM LENILRACVG LAPENNMILE YK